Latest publications

  • Article, review/survey

    Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

    Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

    Part of Frontiers in Medicine, 2021.

    Open access
  • Article, review/survey

    Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

    Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

    Part of Frontiers in Pharmacology, 2021.

    Open access
  • Article in journal

    Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

    Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

    Part of European journal of pharmaceutics and biopharmaceutics, p. 240-251, 2021.

    Open access
  • Article in journal

    Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

    Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

    Part of Cells, 2021.

    Open access
  • Article in journal

    Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

    In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

    Part of Cells, 2021.

    Open access
  • Article in journal

    Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

    Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

    Part of ACTA PHARMACEUTICA SINICA B, p. 1667-1675, 2021.

    Open access
  • Article in journal

    Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

    ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

    Part of Molecular Pharmaceutics, p. 361-372, 2020.

  • Article in journal

    Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

    The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

    Part of Pharmaceutics, 2020.

    Open access
  • Article in journal

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

    Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

    Part of Pharmaceutics, 2020.

    Open access
  • Article in journal

    Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

    Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

    Part of Applied Sciences, 2020.

    Open access
  • Article in journal

    Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

    Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

    Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020.

  • Article, review/survey

    Dahlgren, David; Lennernäs, Hans

    Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

    Part of Molecules, 2020.

    Open access
  • Article, review/survey

    Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

    Part of ADMET & DMPK, p. 375-390, 2020.

    Open access
  • Article in journal

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

    Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

    Part of International Journal of Molecular Sciences, 2020.

    Open access
  • Article in journal

    Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

    Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

    Part of Obesity Science & Practice, p. 313-323, 2020.

    Open access
  • Article in journal

    Augustijns, Patrick; Vertzoni, Maria; Reppas, Christos; Langguth, Peter et al.

    Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

    Part of European Journal of Pharmaceutical Sciences, 2020.

    Open access
  • Article in journal

    Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

    Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

    Part of European journal of pharmaceutics and biopharmaceutics, p. 191-202, 2020.

  • Article in journal

    Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

    Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

    Part of AAPS Journal, 2020.

    Open access
  • Article, review/survey

    Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

    The Critical Role of Passive Permeability in Designing Successful Drugs

    Part of ChemMedChem, p. 1862-1874, 2020.

  • Article in journal

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans et al.

    Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

    Part of Drug Metabolism and Pharmacokinetics, p. S70-S71, 2019.

  • Article, review/survey

    Dahlgren, David; Lennernäs, Hans

    Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

    Part of Pharmaceutics, 2019.

    Open access
  • Article in journal

    Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

    Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

    Part of Journal of Drug Delivery Science and Technology, 2019.

    Open access
  • Article in journal

    Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

    Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

    Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019.

  • Article in journal

    Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

    Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019.

  • Article in journal

    Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

    Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

    Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019.

  • Article in journal

    Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Rat intestinal drug permeability: A status report and summary of repeated determinations

    Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019.

  • Article in journal

    Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

    Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

    Part of Molecular Pharmaceutics, p. 3053-3064, 2019.

  • Article in journal

    Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

    Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

    Part of Cancers, 2019.

    Open access
  • Article in journal

    Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

    Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

    Part of Molecular Pharmaceutics, p. 336-340, 2018.

  • Article in journal

    Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

    Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

    Part of European journal of pharmaceutics and biopharmaceutics, p. 1-12, 2018.

  • Article in journal

    Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

    The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

    Part of International Journal of Pharmaceutics, p. 158-168, 2018.

  • Article in journal

    Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

    Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

    Part of International Journal of Pharmaceutics, p. 239-248, 2018.

  • Article in journal

    Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

    Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

    Part of AAPS Journal, 2018.

    Open access
  • Article, review/survey

    Hens, Bart; Sinko, Patrick D.; Job, Nicholas; Dean, Meagan et al.

    Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

    Part of International Journal of Pharmaceutics, p. 120-127, 2018.

  • Article in journal

    Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar et al.

    Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

    Part of DISSOLUTION TECHNOLOGIES, p. 50-53, 2018.

  • Article in journal

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa P.; Ericsson, Hans et al.

    Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

    Part of Drug Metabolism And Disposition, p. 1420-1433, 2018.

  • Article in journal

    Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

    Single bead investigation of a clinical drug delivery system – a novel release mechanism

    Part of Journal of Controlled Release, p. 235-247, 2018.

    Open access
  • Article in journal

    Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

    Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

    Part of European journal of pharmaceutics and biopharmaceutics, p. 70-76, 2018.

  • Article in journal

    Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

    Part of European journal of pharmaceutics and biopharmaceutics, p. 222-230, 2018.

  • Article in journal

    Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

    Time-dependent effects on small intestinal transport by absorption-modifying excipients

    Part of European journal of pharmaceutics and biopharmaceutics, p. 19-28, 2018.

  • Article in journal

    Lennernäs, Hans; Lindahl, A.; Van Peer, A.; Ollier, C. et al.

    In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

    Part of Molecular Pharmaceutics, p. 1307-1314, 2017.

  • Article in journal

    Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos et al.

    Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

    Part of Drug Development and Industrial Pharmacy, p. 338-346, 2017.

  • Article in journal

    Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

    Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

    Part of International Journal of Pharmaceutics, p. 274-281, 2017.

  • Article in journal

    Dubbelboer, Ilse R.; Lilienberg, Elsa; Sjögren, Erik; Lennernäs, Hans

    A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

    Part of Molecular Pharmaceutics, p. 686-698, 2017.

  • Article in journal

    Lilienberg, Elsa; Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

    Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

    Part of Journal of Pharmacy and Pharmacology (JPP), p. 135-142, 2017.

  • Article in journal

    Tammela, T L; Häggman, Michael; Ladjevardi, Sam; Taari, K et al.

    An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

    Part of Journal of Urology, p. 1333-1339, 2017.

  • Article in journal

    Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

    Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA

    Part of Molecular Pharmaceutics, p. 4243-4251, 2017.

  • Article in journal

    Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Pathak, Shriram M. et al.

    IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

    Part of European Journal of Pharmaceutical Sciences, p. 598-609, 2017.

  • Article in journal

    Darwich, Adam S.; Margolskee, Alison; Pepin, Xavier; Aarons, Leon et al.

    IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Part of European Journal of Pharmaceutical Sciences, p. 626-642, 2017.

  • Article in journal

    Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Aarons, Leon et al.

    IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

    Part of European Journal of Pharmaceutical Sciences, p. 610-625, 2017.