Latest publications
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The progression of doxorubicin-induced intestinal mucositis in rats
Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023.
Article in journal
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Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus
Part of Drug Metabolism and Pharmacokinetics, 2023.
Article in journal
DOI for Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus
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Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
Part of Biomedicine and Pharmacotherapy, 2023.
Article, review/survey
DOI for Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation Download full text (pdf) of Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
Part of International Journal of Molecular Sciences, 2022.
Article in journal
DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
Part of Cells, 2022.
Article in journal
DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
Part of International Journal of Molecular Sciences, 2022.
Article in journal
DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
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Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
Part of Pharmaceutics, 2022.
Article, review/survey
DOI for Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research Download full text (pdf) of Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
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Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review
Part of European Journal of Pharmaceutical Sciences, 2022.
Article, review/survey
DOI for Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review Download full text (pdf) of Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
Part of Metabolites, 2022.
Article in journal
DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding Download full text (pdf) of Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
Part of Basic & Clinical Pharmacology & Toxicology, 2022.
Article in journal
DOI for Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats Download full text (pdf) of Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
Part of BMJ Open, 2022.
Article in journal
DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
Part of CPT, p. 1194-1209, 2022.
Article in journal
DOI for Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction Download full text (pdf) of Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
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Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
Part of European Journal of Pharmaceutical Sciences, 2022.
Article in journal
DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue Download full text (pdf) of Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
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Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare
Part of Frontiers in Medicine, 2021.
Article, review/survey
DOI for Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare Download full text (pdf) of Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare
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Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
Part of Frontiers in Pharmacology, 2021.
Article, review/survey
DOI for Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies Download full text (pdf) of Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
Part of European journal of pharmaceutics and biopharmaceutics, p. 240-251, 2021.
Article in journal
DOI for Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability Download full text (pdf) of Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
Part of Cells, 2021.
Article in journal
DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death Download full text (pdf) of Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
Part of ACTA PHARMACEUTICA SINICA B, p. 1667-1675, 2021.
Article in journal
DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats Download full text (pdf) of Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
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Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
Part of International Journal of Molecular Sciences, 2021.
Article, review/survey
DOI for Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma Download full text (pdf) of Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
Part of International Journal of Molecular Sciences, 2021.
Article in journal
DOI for Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats Download full text (pdf) of Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
Part of Cells, 2021.
Article in journal
DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma Download full text (pdf) of In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
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ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium
Part of Molecular Pharmaceutics, p. 361-372, 2020.
Article in journal
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
Part of Pharmaceutics, 2020.
Article in journal
DOI for The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin Download full text (pdf) of The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
Part of Pharmaceutics, 2020.
Article in journal
DOI for Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat Download full text (pdf) of Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
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Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
Part of Applied Sciences, 2020.
Article in journal
DOI for Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations Download full text (pdf) of Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
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Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project
Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020.
Article in journal
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
Part of Molecules, 2020.
Article, review/survey
DOI for Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective Download full text (pdf) of Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
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Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
Part of ADMET & DMPK, p. 375-390, 2020.
Article, review/survey
DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models Download full text (pdf) of Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
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Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
Part of Obesity Science & Practice, p. 313-323, 2020.
Article in journal
DOI for Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity Download full text (pdf) of Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
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Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications
Part of European Journal of Pharmaceutical Sciences, 2020.
Article in journal
DOI for Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications Download full text (pdf) of Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications
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Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling
Part of European journal of pharmaceutics and biopharmaceutics, p. 191-202, 2020.
Article in journal
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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
Part of AAPS Journal, 2020.
Article in journal
DOI for Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption Download full text (pdf) of Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
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The Critical Role of Passive Permeability in Designing Successful Drugs
Part of ChemMedChem, p. 1862-1874, 2020.
Article, review/survey
DOI for The Critical Role of Passive Permeability in Designing Successful Drugs
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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
Part of International Journal of Molecular Sciences, 2020.
Article in journal
DOI for Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol Download full text (pdf) of Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
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Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions
Part of Drug Metabolism and Pharmacokinetics, p. S70-S71, 2019.
Article in journal
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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
Part of Pharmaceutics, 2019.
Article, review/survey
DOI for Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches Download full text (pdf) of Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
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Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations
Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019.
Article in journal
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Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions
Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019.
Article in journal
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Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model
Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019.
Article in journal
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Rat intestinal drug permeability: A status report and summary of repeated determinations
Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019.
Article in journal
DOI for Rat intestinal drug permeability: A status report and summary of repeated determinations
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Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model
Part of Molecular Pharmaceutics, p. 3053-3064, 2019.
Article in journal
DOI for Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model
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Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
Part of Cancers, 2019.
Article in journal
DOI for Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile Download full text (pdf) of Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
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Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
Part of Journal of Drug Delivery Science and Technology, 2019.
Article in journal
DOI for Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality Download full text (pdf) of Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
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Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"
Part of Molecular Pharmaceutics, p. 336-340, 2018.
Article in journal
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Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis
Part of European journal of pharmaceutics and biopharmaceutics, p. 1-12, 2018.
Article in journal
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The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.
Part of International Journal of Pharmaceutics, p. 158-168, 2018.
Article in journal
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Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.
Part of International Journal of Pharmaceutics, p. 239-248, 2018.
Article in journal
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Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
Part of AAPS Journal, 2018.
Article in journal
DOI for Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment Download full text (pdf) of Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
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Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project
Part of International Journal of Pharmaceutics, p. 120-127, 2018.
Article, review/survey
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Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018
Part of DISSOLUTION TECHNOLOGIES, p. 50-53, 2018.
Article in journal