Latest publications

  • Article, review/survey

    Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

    Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

    Part of Frontiers in Medicine, 2021.

    Open access
  • Article in journal

    Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

    ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

    Part of Molecular Pharmaceutics, p. 361-372, 2020.

  • Article in journal

    Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

    The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

    Part of Pharmaceutics, 2020.

    Open access
  • Article, review/survey

    Keutzer, Lina; Wicha, Sebastian G.; Simonsson, Ulrika S H

    Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

    Part of JMIR mhealth and uhealth, 2020.

  • Article in journal

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

    Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

    Part of Pharmaceutics, 2020.

    Open access
  • Article in journal

    Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

    Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

    Part of Antimicrobial Agents and Chemotherapy, 2020.

    Open access
  • Article in journal

    Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

    Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

    Part of Applied Sciences, 2020.

    Open access
  • Article in journal

    Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

    Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

    Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020.

  • Article in journal

    Keutzer, Lina; Simonsson, Ulrika S. H.

    Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example

    Part of Frontiers in Pharmacology, 2020.

    Open access
  • Article, review/survey

    Dahlgren, David; Lennernäs, Hans

    Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

    Part of Molecules, 2020.

    Open access
  • Article in journal

    Gupta, Neeraj; Bottino, Dean; Simonsson, Ulrika S H; Musante, Cynthia J. et al.

    Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

    Part of Clinical Pharmacology and Therapeutics, p. 1285-1289, 2020.

  • Article in journal

    Faraj, Alan; Clewe, Oskar; Svensson, Robin J.; Mukamolova, Galina V. et al.

    Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

    Part of Scientific Reports, 2020.

    Open access
  • Article, review/survey

    Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

    Part of ADMET & DMPK, p. 375-390, 2020.

    Open access
  • Article in journal

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

    Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

    Part of International Journal of Molecular Sciences, 2020.

    Open access
  • Article in journal

    Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

    Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

    Part of Obesity Science & Practice, p. 313-323, 2020.

    Open access
  • Article in journal

    Augustijns, Patrick; Vertzoni, Maria; Reppas, Christos; Langguth, Peter et al.

    Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

    Part of European Journal of Pharmaceutical Sciences, 2020.

    Open access
  • Article in journal

    Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

    Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

    Part of European journal of pharmaceutics and biopharmaceutics, p. 191-202, 2020.

  • Article in journal

    Susanto, Budi O.; Wicha, Sebastian G; Hu, Yanmin; Coates, Anthony R M et al.

    Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.

    Part of Clinical Pharmacology and Therapeutics, p. 274-286, 2020.

    Open access
  • Article in journal

    Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

    Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

    Part of European Respiratory Journal, 2020.

  • Article in journal

    Clewe, Oskar; Faraj, Alan; Hu, Yanmin; Coates, Anthony R M et al.

    A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

    Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 421-430, 2020.

  • Article in journal

    Van Wijk, Rob C.; van der Sar, Astrid M.; Krekels, Elke H. J.; Verboom, Theo et al.

    Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

    Part of Clinical and Translational Science, p. 1060-1064, 2020.

    Open access
  • Article in journal

    Van Wijk, Rob C.; Hu, Wanbin; Dijkema, Sharka M.; Van den Berg, Dirk-Jan et al.

    Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

    Part of British Journal of Pharmacology, p. 5518-5533, 2020.

    Open access
  • Article in journal

    Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

    Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

    Part of AAPS Journal, 2020.

    Open access
  • Article in journal

    Susanto, Budi Octasari; Svensson, Robin J.; Svensson, Elin M.; Aarnoutse, Rob et al.

    Rifampicin can be given as flat-dosing instead of weight-band dosing

    Part of Clinical Infectious Diseases, p. 3055-3060, 2020.

    Open access
  • Article in journal

    Keutzer, Lina; Simonsson, Ulrika S. H.

    Medical Device Apps: An Introduction to Regulatory Affairs for Developers

    Part of JMIR mhealth and uhealth, 2020.

    Open access
  • Article in journal

    Selch Larsen, Malte; Vestergaard Juul, Rasmus; Zintner, Shannon M.; Kristensen, Annemarie T. et al.

    Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis

    Part of Haemophilia, p. 164-172, 2020.

  • Article, review/survey

    Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z et al.

    The Critical Role of Passive Permeability in Designing Successful Drugs

    Part of ChemMedChem, p. 1862-1874, 2020.

    Open access
  • Article in journal

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans et al.

    Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

    Part of Drug Metabolism and Pharmacokinetics, p. S70-S71, 2019.

  • Article, review/survey

    Dahlgren, David; Lennernäs, Hans

    Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

    Part of Pharmaceutics, 2019.

    Open access
  • Article in journal

    Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

    Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

    Part of Journal of Drug Delivery Science and Technology, 2019.

    Open access
  • Article in journal

    Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

    Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

    Part of Cancers, 2019.

    Open access
  • Article in journal

    Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

    Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

    Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019.

  • Article in journal

    Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

    Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019.

  • Article in journal

    Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

    Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

    Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019.

  • Article in journal

    Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Rat intestinal drug permeability: A status report and summary of repeated determinations

    Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019.

  • Article in journal

    Svensson, Robin J.; Niward, Katarina; Davies Forsman, Lina; Bruchfeld, Judith et al.

    Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis

    Part of British Journal of Clinical Pharmacology, p. 2341-2350, 2019.

  • Article in journal

    Svensson, Robin J.; Sabiiti, Wilber; Kibiki, Gibson S.; Ntinginya, Nyanda E. et al.

    Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

    Part of Antimicrobial Agents and Chemotherapy, 2019.

  • Article in journal

    Wyatt, David; Strauss, David; Ray, Balmiki; Mehta, Krina et al.

    Consider ASCPT in Your End-of-Year Giving

    Part of Clinical Pharmacology and Therapeutics, p. 17-21, 2019.

  • Article in journal

    Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

    Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

    Part of Molecular Pharmaceutics, p. 3053-3064, 2019.

  • Article in journal

    Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

    Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

    Part of Molecular Pharmaceutics, p. 336-340, 2018.

  • Article in journal

    Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

    Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

    Part of European journal of pharmaceutics and biopharmaceutics, p. 1-12, 2018.

  • Article in journal

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing; Simonsson, Ulrika S H et al.

    Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

    Part of European Journal of Pharmaceutical Sciences, p. 196-203, 2018.

  • Article in journal

    Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

    The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

    Part of International Journal of Pharmaceutics, p. 158-168, 2018.

  • Article in journal

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Kreilgaard, Mads; Kristensen, Annemarie T. et al.

    Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

    Part of European Journal of Pharmaceutical Sciences, p. 531-538, 2018.

  • Article in journal

    Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

    Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

    Part of International Journal of Pharmaceutics, p. 239-248, 2018.

  • Article in journal

    Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

    Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

    Part of AAPS Journal, 2018.

    Open access
  • Article, review/survey

    Hens, Bart; Sinko, Patrick D.; Job, Nicholas; Dean, Meagan et al.

    Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

    Part of International Journal of Pharmaceutics, p. 120-127, 2018.

  • Article in journal

    Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar et al.

    Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

    Part of DISSOLUTION TECHNOLOGIES, p. 50 50-53 53, 2018.

  • Article in journal

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa P.; Ericsson, Hans et al.

    Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

    Part of Drug Metabolism And Disposition, p. 1420-1433, 2018.

  • Article in journal

    Wicha, Sebastian G.; Clewe, Oskar; Svensson, Robin J.; Gillespie, Stephen H. et al.

    Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin

    Part of Clinical Pharmacology and Therapeutics, p. 1208-1218, 2018.

    Open access