Department of Pharmaceutical Biosciences

Department of Pharmaceutical ... Research Translational Drug Discovery ... Publikationer

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Latest publications

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Ayoun Alsoud, Rami; Svensson, Robin J.; Svensson, Elin; Gillespie, Stephen H. H. et al.

Part of Frontiers in Pharmacology, 2023.

Article in journal

DOI for Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development Download full text (pdf) of Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

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Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Part of Drug Metabolism and Pharmacokinetics, 2023.

Article in journal

DOI for Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus
Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Dahlgren, David; Lennernäs, Hans

Part of Biomedicine and Pharmacotherapy, 2023.

Article, review/survey

DOI for Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation Download full text (pdf) of Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

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Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Mockeliunas, Laurynas; Faraj, Alan; Van Wijk, Rob C; Upton, Caryn M. et al.

Part of Frontiers in Pharmacology, 2023.

Article in journal

DOI for Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development Download full text (pdf) of Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

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Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects

Koele, Simon E.; Phillips, Patrick P. J.; Upton, Caryn M.; van Ingen, Jakko et al.

Part of International Journal of Antimicrobial Agents, 2023.

Article, review/survey

DOI for Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects Download full text (pdf) of Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects

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Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin

Susanto, Budi O.; Svensson, Elin M.; te Brake, Lindsey; Aarnoutse, Rob E. et al.

Part of International Journal of Antimicrobial Agents, 2023.

Article in journal

DOI for Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin Download full text (pdf) of Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin

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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023.

Article in journal

DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma Download full text (pdf) of Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

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Clinical standards for the management of adverse effects during treatment for TB

Singh, K. P.; Carvalho, A. C. C.; Centis, R.; D'Ambrosio, L. et al.

Part of The International Journal of Tuberculosis and Lung Disease, p. 506-519, 2023.

Article in journal

DOI for Clinical standards for the management of adverse effects during treatment for TB Download full text (pdf) of Clinical standards for the management of adverse effects during treatment for TB

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Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Faraj, Alan; Van Wijk, Rob C; Neuman, Linda; Desai, Shraddha et al.

Part of CPT, p. 977-987, 2023.

Article in journal

DOI for Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy Download full text (pdf) of Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

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Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients

Faraj, Alan; Le Moan, Natacha; Gorina, Eduard; Blouse, Grant E. E. et al.

Part of Advances in Therapy, p. 3739-3750, 2023.

Article in journal

DOI for Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients Download full text (pdf) of Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients

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Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.

Larfors, Gunnar; Andersson, Per; Jesson, Gérald; Liljebris, Charlotta et al.

Part of European Journal of Haematology, 2023.

Article in journal

DOI for Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions. Download full text (pdf) of Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.

Open access
Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 507-516, 2023.

Article in journal

DOI for Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats Download full text (pdf) of Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

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Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Van Wijk, Rob C; Lucia, Ainhoa; Sudhakar, Pavan Kumar; Sonnenkalb, Lindsay et al.

Part of iScience, 2023.

Article in journal

DOI for Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium Download full text (pdf) of Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

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Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Van Wijk, Rob C; Lucia, Ainhoa; Sudhakar, Pavan Kumar; Sonnenkalb, Lindsay et al.

Part of ISCIENCE, 2023.

Article in journal

DOI for Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Open access
The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023.

Article in journal

DOI for The progression of doxorubicin-induced intestinal mucositis in rats Download full text (pdf) of The progression of doxorubicin-induced intestinal mucositis in rats

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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022.

Article in journal

DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022.

Article in journal

DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Mockeliunas, Laurynas; Keutzer, Lina; Sturkenboom, Marieke G. G.; Bolhuis, Mathieu S. et al.

Part of Pharmaceutics, 2022.

Article in journal

DOI for Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis Download full text (pdf) of Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

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Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Senekowitsch, Stefan; Schick, Philipp; Abrahamsson, Bertil; Augustijns, Patrick et al.

Part of Pharmaceutics, 2022.

Article, review/survey

DOI for Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research Download full text (pdf) of Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

De Jager, Veronique; Gupte, Nikhil; Nunes, Silvia; Barnes, Grace L. et al.

Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022.

Article in journal

DOI for Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial
Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

O'Shea, Joseph P.; Augustijns, Patrick; Brandl, Martin; Brayden, David J. et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

Article, review/survey

DOI for Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review Download full text (pdf) of Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

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Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

Ruth, Mike Marvin; Raaijmakers, Jelmer; van den Hombergh, Erik; Aarnoutse, Rob et al.

Part of Clinical Microbiology and Infection, p. 448.e1-448.e7, 2022.

Article in journal

DOI for Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics Download full text (pdf) of Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

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Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

Van Wijk, Rob C; Simonsson, Ulrika S. H.

Part of CPT, p. 991-1001, 2022.

Article in journal

DOI for Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application Download full text (pdf) of Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

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Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Keutzer, Lina; You, Huifang; Farnoud, Ali; Nyberg, Joakim et al.

Part of Pharmaceutics, 2022.

Article in journal

DOI for Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Download full text (pdf) of Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

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A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

Keutzer, Lina; Akhondipour, Yasamin; Forsman, Lina Davies; Simonsson, Ulrika S. H.

Part of CPT, p. 628-639, 2022.

Article in journal

DOI for A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study Download full text (pdf) of A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

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Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

Mudde, Saskia E.; Ayoun Alsoud, Rami; van der Meijden, Aart; Upton, Anna M. et al.

Part of Journal of Infectious Diseases, p. 1876-1885, 2022.

Article in journal

DOI for Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data Download full text (pdf) of Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022.

Article in journal

DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding Download full text (pdf) of Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

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Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Part of Basic & Clinical Pharmacology & Toxicology, 2022.

Article in journal

DOI for Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats Download full text (pdf) of Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

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Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

Alffenaar, Jan-Willem C.; de Steenwinkel, Jurriaan E. M.; Diacon, Andreas H.; Simonsson, Ulrika S. H. et al.

Part of Frontiers in Pharmacology, 2022.

Article, review/survey

DOI for Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies Download full text (pdf) of Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

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Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

Article in journal

DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue Download full text (pdf) of Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

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Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Faraj, Alan; Knudsen, Tom; Desai, Shraddha; Neuman, Linda et al.

Part of CPT, p. 1628-1637, 2022.

Article in journal

DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug Download full text (pdf) of Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

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Pharmacometrics in tuberculosis: progress and opportunities

Wilkins, Justin J.; Svensson, Elin; Ernest, Jacqueline P.; Savic, Radojka M. et al.

Part of International Journal of Antimicrobial Agents, 2022.

Article in journal

DOI for Pharmacometrics in tuberculosis: progress and opportunities Download full text (pdf) of Pharmacometrics in tuberculosis: progress and opportunities

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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

Upton, Caryn M.; Van Wijk, Rob C; Mockeliunas, Laurynas; Simonsson, Ulrika S. H. et al.

Part of eClinicalMedicine, 2022.

Article in journal

DOI for Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial Download full text (pdf) of Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022.

Article in journal

DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Open access
Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

Ekqvist, David; Bornefall, Anna; Augustinsson, Daniel; Sönnerbrandt, Martina et al.

Part of BMJ Open, 2022.

Article in journal

DOI for Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP) Download full text (pdf) of Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

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Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Garcia, Luna Prieto; Lundahl, Anna; Ahlstrom, Christine; Vildhede, Anna et al.

Part of CPT, p. 1194-1209, 2022.

Article in journal

DOI for Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction Download full text (pdf) of Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022.

Article in journal

DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

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Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

Part of Frontiers in Medicine, 2021.

Article, review/survey

DOI for Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare Download full text (pdf) of Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

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Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Part of Frontiers in Pharmacology, 2021.

Article, review/survey

DOI for Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies Download full text (pdf) of Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 240-251, 2021.

Article in journal

DOI for Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability Download full text (pdf) of Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Part of Cells, 2021.

Article in journal

DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death Download full text (pdf) of Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

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Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

Part of European Respiratory Journal, 2021.

Article in journal

DOI for Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Open access
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model

Pieterman, Elise D.; Keutzer, Lina; van der Meijden, Aart; van den Berg, Sanne et al.

Part of Journal of Infectious Diseases, p. 1039-1047, 2021.

Article in journal

DOI for Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model
Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Ebeling Barbier, Charlotte; Heindryckx, Femke; Lennernäs, Hans

Part of International Journal of Molecular Sciences, 2021.

Article, review/survey

DOI for Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma Download full text (pdf) of Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021.

Article in journal

DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma Download full text (pdf) of In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Part of Acta Pharmaceutica Sinica B, p. 1667-1675, 2021.

Article in journal

DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats Download full text (pdf) of Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Peters, Karsten; Dahlgren, David; Lennernäs, Hans; Sjöblom, Markus

Part of International Journal of Molecular Sciences, 2021.

Article in journal

DOI for Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats Download full text (pdf) of Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

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ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

Part of Molecular Pharmaceutics, p. 361-372, 2020.

Article in journal

DOI for ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium
The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Part of Pharmaceutics, 2020.

Article in journal

DOI for The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin Download full text (pdf) of The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Open access
Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

Keutzer, Lina; Wicha, Sebastian G.; Simonsson, Ulrika S H

Part of JMIR mhealth and uhealth, 2020.

Article, review/survey

DOI for Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review