Latest publications

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Ayoun Alsoud, Rami; Svensson, Robin J.; Svensson, Elin; Gillespie, Stephen H. H. et al.

Part of Frontiers in Pharmacology, 2023.

Article in journal

DOI for Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development Download full text (pdf) of Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Mockeliunas, Laurynas; Faraj, Alan; Van Wijk, Rob C; Upton, Caryn M. et al.

Part of Frontiers in Pharmacology, 2023.

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DOI for Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development Download full text (pdf) of Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects

Koele, Simon E.; Phillips, Patrick P. J.; Upton, Caryn M.; van Ingen, Jakko et al.

Part of International Journal of Antimicrobial Agents, 2023.

Article, review/survey

DOI for Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects Download full text (pdf) of Early bactericidal activity studies for pulmonary tuberculosis: A systematic review of methodological aspects

Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin

Susanto, Budi O.; Svensson, Elin M.; te Brake, Lindsey; Aarnoutse, Rob E. et al.

Part of International Journal of Antimicrobial Agents, 2023.

Article in journal

DOI for Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin Download full text (pdf) of Model-based analysis of bactericidal activity and a new dosing strategy for optimised-dose rifampicin

Clinical standards for the management of adverse effects during treatment for TB

Singh, K. P.; Carvalho, A. C. C.; Centis, R.; D'Ambrosio, L. et al.

Part of The International Journal of Tuberculosis and Lung Disease, p. 506-519, 2023.

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DOI for Clinical standards for the management of adverse effects during treatment for TB Download full text (pdf) of Clinical standards for the management of adverse effects during treatment for TB

Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Faraj, Alan; Van Wijk, Rob C; Neuman, Linda; Desai, Shraddha et al.

Part of CPT, p. 977-987, 2023.

Article in journal

DOI for Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy Download full text (pdf) of Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients

Faraj, Alan; Le Moan, Natacha; Gorina, Eduard; Blouse, Grant E. E. et al.

Part of Advances in Therapy, p. 3739-3750, 2023.

Article in journal

DOI for Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients Download full text (pdf) of Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients

Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Van Wijk, Rob C; Lucia, Ainhoa; Sudhakar, Pavan Kumar; Sonnenkalb, Lindsay et al.

Part of iScience, 2023.

Article in journal

DOI for Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium Download full text (pdf) of Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Van Wijk, Rob C; Lucia, Ainhoa; Sudhakar, Pavan Kumar; Sonnenkalb, Lindsay et al.

Part of ISCIENCE, 2023.

Article in journal

DOI for Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Mockeliunas, Laurynas; Keutzer, Lina; Sturkenboom, Marieke G. G.; Bolhuis, Mathieu S. et al.

Part of Pharmaceutics, 2022.

Article in journal

DOI for Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis Download full text (pdf) of Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

De Jager, Veronique; Gupte, Nikhil; Nunes, Silvia; Barnes, Grace L. et al.

Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022.

Article in journal

DOI for Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

Ruth, Mike Marvin; Raaijmakers, Jelmer; van den Hombergh, Erik; Aarnoutse, Rob et al.

Part of Clinical Microbiology and Infection, p. 448.e1-448.e7, 2022.

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DOI for Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics Download full text (pdf) of Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

Van Wijk, Rob C; Simonsson, Ulrika S. H.

Part of CPT, p. 991-1001, 2022.

Article in journal

DOI for Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application Download full text (pdf) of Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Keutzer, Lina; You, Huifang; Farnoud, Ali; Nyberg, Joakim et al.

Part of Pharmaceutics, 2022.

Article in journal

DOI for Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Download full text (pdf) of Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

Keutzer, Lina; Akhondipour, Yasamin; Forsman, Lina Davies; Simonsson, Ulrika S. H.

Part of CPT, p. 628-639, 2022.

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DOI for A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study Download full text (pdf) of A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

Mudde, Saskia E.; Ayoun Alsoud, Rami; van der Meijden, Aart; Upton, Anna M. et al.

Part of Journal of Infectious Diseases, p. 1876-1885, 2022.

Article in journal

DOI for Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data Download full text (pdf) of Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

Alffenaar, Jan-Willem C.; de Steenwinkel, Jurriaan E. M.; Diacon, Andreas H.; Simonsson, Ulrika S. H. et al.

Part of Frontiers in Pharmacology, 2022.

Article, review/survey

DOI for Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies Download full text (pdf) of Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Faraj, Alan; Knudsen, Tom; Desai, Shraddha; Neuman, Linda et al.

Part of CPT, p. 1628-1637, 2022.

Article in journal

DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug Download full text (pdf) of Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Pharmacometrics in tuberculosis: progress and opportunities

Wilkins, Justin J.; Svensson, Elin; Ernest, Jacqueline P.; Savic, Radojka M. et al.

Part of International Journal of Antimicrobial Agents, 2022.

Article in journal

DOI for Pharmacometrics in tuberculosis: progress and opportunities Download full text (pdf) of Pharmacometrics in tuberculosis: progress and opportunities

Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

Upton, Caryn M.; Van Wijk, Rob C; Mockeliunas, Laurynas; Simonsson, Ulrika S. H. et al.

Part of eClinicalMedicine, 2022.

Article in journal

DOI for Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial Download full text (pdf) of Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022.

Article in journal

DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

Ekqvist, David; Bornefall, Anna; Augustinsson, Daniel; Sönnerbrandt, Martina et al.

Part of BMJ Open, 2022.

Article in journal

DOI for Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP) Download full text (pdf) of Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

Part of European Respiratory Journal, 2021.

Article in journal

DOI for Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model

Pieterman, Elise D.; Keutzer, Lina; van der Meijden, Aart; van den Berg, Sanne et al.

Part of Journal of Infectious Diseases, p. 1039-1047, 2021.

Article in journal

DOI for Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model

Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

Keutzer, Lina; Wicha, Sebastian G.; Simonsson, Ulrika S H

Part of JMIR mhealth and uhealth, 2020.

Article, review/survey

DOI for Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

Part of Antimicrobial Agents and Chemotherapy, 2020.

Article in journal

DOI for Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients Download full text (pdf) of Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example

Keutzer, Lina; Simonsson, Ulrika S. H.

Part of Frontiers in Pharmacology, 2020.

Article in journal

DOI for Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example Download full text (pdf) of Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example

Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

Gupta, Neeraj; Bottino, Dean; Simonsson, Ulrika S H; Musante, Cynthia J. et al.

Part of Clinical Pharmacology and Therapeutics, p. 1285-1289, 2020.

Article in journal

DOI for Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.

Susanto, Budi O.; Wicha, Sebastian G; Hu, Yanmin; Coates, Anthony R M et al.

Part of Clinical Pharmacology and Therapeutics, p. 274-286, 2020.

Article in journal

DOI for Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development. Download full text (pdf) of Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.

Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

Van Wijk, Rob C.; van der Sar, Astrid M.; Krekels, Elke H. J.; Verboom, Theo et al.

Part of Clinical and Translational Science, p. 1060-1064, 2020.

Article in journal

DOI for Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development Download full text (pdf) of Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

Van Wijk, Rob C.; Hu, Wanbin; Dijkema, Sharka M.; Van den Berg, Dirk-Jan et al.

Part of British Journal of Pharmacology, p. 5518-5533, 2020.

Article in journal

DOI for Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans Download full text (pdf) of Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

Rifampicin can be given as flat-dosing instead of weight-band dosing

Susanto, Budi Octasari; Svensson, Robin J.; Svensson, Elin M.; Aarnoutse, Rob et al.

Part of Clinical Infectious Diseases, p. 3055-3060, 2020.

Article in journal

DOI for Rifampicin can be given as flat-dosing instead of weight-band dosing Download full text (pdf) of Rifampicin can be given as flat-dosing instead of weight-band dosing

Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis

Selch Larsen, Malte; Vestergaard Juul, Rasmus; Zintner, Shannon M.; Kristensen, Annemarie T. et al.

Part of Haemophilia, p. 164-172, 2020.

Article in journal

DOI for Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis

A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

Clewe, Oskar; Faraj, Alan; Hu, Yanmin; Coates, Anthony R M et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 421-430, 2020.

Article in journal

DOI for A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis. Download full text (pdf) of A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

Medical Device Apps: An Introduction to Regulatory Affairs for Developers

Keutzer, Lina; Simonsson, Ulrika S. H.

Part of JMIR mhealth and uhealth, 2020.

Article in journal

DOI for Medical Device Apps: An Introduction to Regulatory Affairs for Developers Download full text (pdf) of Medical Device Apps: An Introduction to Regulatory Affairs for Developers

Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

Faraj, Alan; Clewe, Oskar; Svensson, Robin J.; Mukamolova, Galina V. et al.

Part of Scientific Reports, 2020.

Article in journal

DOI for Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions Download full text (pdf) of Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Part of Applied Sciences, 2020.

Article in journal

DOI for Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations Download full text (pdf) of Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis

Svensson, Robin J.; Niward, Katarina; Davies Forsman, Lina; Bruchfeld, Judith et al.

Part of British Journal of Clinical Pharmacology, p. 2341-2350, 2019.

Article in journal

DOI for Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis

Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

Svensson, Robin J.; Sabiiti, Wilber; Kibiki, Gibson S.; Ntinginya, Nyanda E. et al.

Part of Antimicrobial Agents and Chemotherapy, 2019.

Article in journal

DOI for Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

Consider ASCPT in Your End-of-Year Giving

Wyatt, David; Strauss, David; Ray, Balmiki; Mehta, Krina et al.

Part of Clinical Pharmacology and Therapeutics, p. 17-21, 2019.

Article in journal

Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing; Simonsson, Ulrika S H et al.

Part of European Journal of Pharmaceutical Sciences, p. 196-203, 2018.

Article in journal

DOI for Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Kreilgaard, Mads; Kristensen, Annemarie T. et al.

Part of European Journal of Pharmaceutical Sciences, p. 531-538, 2018.

Article in journal

DOI for Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin

Wicha, Sebastian G.; Clewe, Oskar; Svensson, Robin J.; Gillespie, Stephen H. et al.

Part of Clinical Pharmacology and Therapeutics, p. 1208-1218, 2018.

Article in journal

DOI for Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin Download full text (pdf) of Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin

A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses

Svensson, Robin J.; Aarnoutse, Rob E; Diacon, Andreas H; Dawson, Rodney et al.

Part of Clinical Pharmacology and Therapeutics, p. 674-683, 2018.

Article in journal

DOI for A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses Download full text (pdf) of A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses

Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations

Svensson, Robin J.; Svensson, Elin; Aarnoutse, Rob E.; Diacon, Andreas H. et al.

Part of Journal of Infectious Diseases, p. 991-999, 2018.

Article in journal

DOI for Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations

The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis

Svensson, Elin M.; Svensson, Robin J.; te Brake, Lindsey H. M.; Boeree, Martin J. et al.

Part of Clinical Infectious Diseases, p. 34-41, 2018.

Article in journal

DOI for The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis Download full text (pdf) of The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis

Distribution of plasma concentrations of first-line anti-TB drugs and individual MICs: a prospective cohort study in a low endemic setting

Niward, Katarina; Forsman, Lina Davies; Bruchfeld, Judith; Chryssanthou, Erja et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2838-2845, 2018.

Article in journal

DOI for Distribution of plasma concentrations of first-line anti-TB drugs and individual MICs: a prospective cohort study in a low endemic setting

A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations

Clewe, Oskar; Wicha, Sebastian G.; de Vogel, Corne P.; de Steenwinkel, Jurriaan E. M. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 437-447, 2018.

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DOI for A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations Download full text (pdf) of A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations

Improving treatment outcome assessment in a mouse tuberculosis model

Mourik, Bas C.; Svensson, Robin J.; de Knegt, Gerjo J.; Bax, Hannelore I. et al.

Part of Scientific Reports, 2018.

Article in journal

DOI for Improving treatment outcome assessment in a mouse tuberculosis model Download full text (pdf) of Improving treatment outcome assessment in a mouse tuberculosis model

Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations

Chen, Chunli; Wicha, Sebastian G.; Nordgren, Rikard; Simonsson, Ulrika S H

Part of AAPS Journal, 2018.

Article in journal

DOI for Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations Download full text (pdf) of Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations