Latest publications
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Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development
Part of Frontiers in Pharmacology, 2023.
Article in journal
DOI for Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development Download full text (pdf) of Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development
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Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development
Part of Frontiers in Pharmacology, 2023.
Article in journal
DOI for Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development Download full text (pdf) of Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development
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Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
Part of BMJ Open, 2022.
Article in journal
DOI for Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP) Download full text (pdf) of Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis
Part of Pharmaceutics, 2022.
Article in journal
DOI for Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis Download full text (pdf) of Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis
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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial
Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022.
Article in journal
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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial
Part of EClinicalMedicine, 2022.
Article in journal
DOI for Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial Download full text (pdf) of Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial
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Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics
Part of Clinical Microbiology and Infection, p. 448.e1-448.e7, 2022.
Article in journal
DOI for Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics Download full text (pdf) of Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics
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Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application
Part of CPT, p. 991-1001, 2022.
Article in journal
DOI for Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application Download full text (pdf) of Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application
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Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin
Part of Pharmaceutics, 2022.
Article in journal
DOI for Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Download full text (pdf) of Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin
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A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study
Part of CPT, p. 628-639, 2022.
Article in journal
DOI for A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study Download full text (pdf) of A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study
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Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data
Part of Journal of Infectious Diseases, p. 1876-1885, 2022.
Article in journal
DOI for Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data Download full text (pdf) of Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
Part of BMJ Open, 2022.
Article in journal
DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies
Part of Frontiers in Pharmacology, 2022.
Article, review/survey
DOI for Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies Download full text (pdf) of Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies
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Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
Part of CPT, p. 1628-1637, 2022.
Article in journal
DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug Download full text (pdf) of Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
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Pharmacometrics in tuberculosis: progress and opportunities
Part of International Journal of Antimicrobial Agents, 2022.
Article in journal
DOI for Pharmacometrics in tuberculosis: progress and opportunities Download full text (pdf) of Pharmacometrics in tuberculosis: progress and opportunities
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Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.
Part of European Respiratory Journal, 2021.
Article in journal
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Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model
Part of Journal of Infectious Diseases, p. 1039-1047, 2021.
Article in journal
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Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review
Part of JMIR mhealth and uhealth, 2020.
Article, review/survey
DOI for Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review
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Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients
Part of Antimicrobial Agents and Chemotherapy, 2020.
Article in journal
DOI for Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients Download full text (pdf) of Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients
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Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
Part of Applied Sciences, 2020.
Article in journal
DOI for Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations Download full text (pdf) of Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
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Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example
Part of Frontiers in Pharmacology, 2020.
Article in journal
DOI for Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example Download full text (pdf) of Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example
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Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development
Part of Clinical Pharmacology and Therapeutics, p. 1285-1289, 2020.
Article in journal
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Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.
Part of Clinical Pharmacology and Therapeutics, p. 274-286, 2020.
Article in journal
DOI for Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development. Download full text (pdf) of Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.
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Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development
Part of Clinical and Translational Science, p. 1060-1064, 2020.
Article in journal
DOI for Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development Download full text (pdf) of Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development
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Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans
Part of British Journal of Pharmacology, p. 5518-5533, 2020.
Article in journal
DOI for Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans Download full text (pdf) of Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans
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Rifampicin can be given as flat-dosing instead of weight-band dosing
Part of Clinical Infectious Diseases, p. 3055-3060, 2020.
Article in journal
DOI for Rifampicin can be given as flat-dosing instead of weight-band dosing Download full text (pdf) of Rifampicin can be given as flat-dosing instead of weight-band dosing
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Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis
Part of Haemophilia, p. 164-172, 2020.
Article in journal
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A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.
Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 421-430, 2020.
Article in journal
DOI for A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis. Download full text (pdf) of A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.
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Medical Device Apps: An Introduction to Regulatory Affairs for Developers
Part of JMIR mhealth and uhealth, 2020.
Article in journal
DOI for Medical Device Apps: An Introduction to Regulatory Affairs for Developers Download full text (pdf) of Medical Device Apps: An Introduction to Regulatory Affairs for Developers
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Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions
Part of Scientific Reports, 2020.
Article in journal
DOI for Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions Download full text (pdf) of Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions
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Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis
Part of British Journal of Clinical Pharmacology, p. 2341-2350, 2019.
Article in journal
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Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture
Part of Antimicrobial Agents and Chemotherapy, 2019.
Article in journal
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Consider ASCPT in Your End-of-Year Giving
Part of Clinical Pharmacology and Therapeutics, p. 17-21, 2019.
Article in journal
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Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia
Part of European Journal of Pharmaceutical Sciences, p. 196-203, 2018.
Article in journal
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Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors
Part of European Journal of Pharmaceutical Sciences, p. 531-538, 2018.
Article in journal
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Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin
Part of Clinical Pharmacology and Therapeutics, p. 1208-1218, 2018.
Article in journal
DOI for Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin Download full text (pdf) of Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin
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Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study
Part of BMJ Open, 2018.
Article in journal
DOI for Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study Download full text (pdf) of Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study
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A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses
Part of Clinical Pharmacology and Therapeutics, p. 674-683, 2018.
Article in journal
DOI for A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses Download full text (pdf) of A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses
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Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations
Part of Journal of Infectious Diseases, p. 991-999, 2018.
Article in journal
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The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis
Part of Clinical Infectious Diseases, p. 34-41, 2018.
Article in journal
DOI for The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis Download full text (pdf) of The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis
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Distribution of plasma concentrations of first-line anti-TB drugs and individual MICs: a prospective cohort study in a low endemic setting
Part of Journal of Antimicrobial Chemotherapy, p. 2838-2845, 2018.
Article in journal
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A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations
Part of Journal of Antimicrobial Chemotherapy, p. 437-447, 2018.
Article in journal
DOI for A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations Download full text (pdf) of A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations
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Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations
Part of AAPS Journal, 2018.
Article in journal
DOI for Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations Download full text (pdf) of Comparisons of analysis methods for assessment of pharmacodynamic interactions including design recommendations
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The implications of model-informed drug discovery and development for tuberculosis
Part of Drug Discovery Today, p. 481-486, 2017.
Article, review/survey
DOI for The implications of model-informed drug discovery and development for tuberculosis
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Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches
Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 325-333, 2017.
Article in journal
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Assessing Pharmacodynamic Interactions in Mice using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models
Part of CPT, p. 787-797, 2017.
Article in journal
DOI for Assessing Pharmacodynamic Interactions in Mice using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models Download full text (pdf) of Assessing Pharmacodynamic Interactions in Mice using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models
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Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods
Part of Journal of Antimicrobial Chemotherapy, p. 2311-2319, 2017.
Article in journal
DOI for Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods Download full text (pdf) of Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods
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Residual Spinal Cord Compression Following Hemilaminectomy and Mini-Hemilaminectomy in Dogs: A Prospective Randomized Study
Part of Frontiers in Veterinary Science, 2017.
Article in journal
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A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain
Part of Pharmaceutical research, p. 1093-1103, 2016.
Article in journal