Spatial Mass Spectrometry

Our research group (PI, Prof. Per Andrén) uses mass spectrometry imaging (MSI) to study the spatial localization of small endogenous compounds, e.g., neurotransmitters, metabolites, lipids, peptides, proteins, as well as drugs and their metabolites in biological tissue sections. Our main focus is to study neurochemical processes in Parkinson's disease (PD), specifically L-Dopa-induced dyskinesia (LID), Lewy body dementia (LBD) and PD dementia. Besides our own research activities, we are also part of the SciLifeLab platform Spatial Biology, collaborating with both academic researchers and industry. Erik Jansson (Assistant Professor, PI) leads a team working on method development for proteomic analysis. His team studies in particular, protein structure with hydrogen–deuterium exchange, and does biochemical pathway identification with thermal proteome profiling.