Selected publications

Hultqvist, G., Syvänen, S., Fang, X.T., Lannfelt, L., and Sehlin, D. (2017). Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor. Theranostics. 2017; 7(2): 308-318

Fang, X.T., Sehlin, D., Lannfelt, L., Syvänen, S. and Hultqvist, G. (2017). Efficient and inexpensive transient expression of multispecific multivalent antibodies in expi293 cells. Biological Procedures Online. 19. 1480-9222

Hultqvist, G., Åberg, E., Camilloni, C., Celestine, C., Sundell, G., Andersson, E., Dogan, J., Vendruscolo, M. and Jemth, P.. Emergence and evolution of a protein-protein interaction between intrinsically disordered domains. In press, eLife. 2017;6:e16059

Åberg, E., Saccoccia, F., Grabherr, M., Ore, W.Y.J., Jemth, P. and Hultqvist, G. (2017). Evolution of the p53-MDM2 pathway. BMC Evol Biol 3;17(1):177

Syvänen, S., Hultqvist, G., Gustavsson, T., Gumucio, A., Laudon, H., Söderberg, L., Ingelsson, M., Lannfelt, L. and Sehlin, D. (2018). Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain penetrating bifunctional antibody. Alzheimer's Research & Therapy (in press)

            Meier, S. R., Syvänen, S., Hultqvist, G., Fang, X. T., Roshanbin, S., Lannfelt, L., Neumann, U. and Sehlin, D. (2018). Antibody-based in vivo PET imaging detects amyloid-β reduction in Alzheimer transgenic mice after BACE-1 inhibition. Journal of Nuclear Medicine. (in press)

       Syvänen, S., Fang, X.T., Hultqvist, G., Meier, S.R., Lannfelt. L., and Sehlin, D. (2017). A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils-a new concept for neuroimaging. NeuroImage

Hultqvist, G., Haq, S.R., Punekar, A.S., Chi, C.N., Engström, Å., Bach, A., Strømgaard, K., Selmer, M., Gianni, S., and Jemth, P. (2013). Energetic pathway sampling in a protein interaction domain. Structure 21, 1193–1202.

            Eildal, J.N.N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, K., and Jemth, P. (2013). Probing the role of backbone hydrogen bonds in protein–peptide interactions by amide-to-ester mutations. J. Am. Chem. Soc. 135, 12998–13007.

Hultqvist, G., Punekar, A.S., Morrone, A., Chi, C.N., Engström, Å., Selmer, M., Gianni, S., and Jemth, P. (2012). Tolerance of protein folding to a circular permutation in a PDZ domain. PLoS ONE 7, e50055.

Hultqvist, G., Pedersen, S.W., Chi, C.N., Strømgaard, K., Gianni, S., and Jemth, P. (2012). An expanded view of the protein folding landscape of PDZ domains. Biochem. Biophys. Res. Commun. 421, 550–553.

Hultqvist, G., Ocampo Daza, D., Larhammar, D., and Kilimann, M.W. (2012). Evolution of the vertebrate Paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS ONE 7, e41850.