Recent publications

  • Eltahir, mohmo394; Fletcher, E.; Dynesius, L.; Jarblad, J. L. et al.

    Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients

    Part of International Immunopharmacology, 2021.

    Open access
  • Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

    Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

    Part of PLOS ONE, 2021.

    Open access
  • van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

    Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

    Part of Nature Communications, 2021.

    Open access
  • Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Karre, Klas et al.

    Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade

    Part of Cancers, 2021.

    Open access
  • Havervall, Sebastian; Rosell, Axel; Phillipson, Mia; Mangsbo, Sara et al.

    Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers

    Part of Journal of the American Medical Association (JAMA), p. 2015-2016, 2021.

  • Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

    Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

    Part of Oncoimmunology, 2020.

    Open access
  • Rostedt Punga, Anna; Strömme, Maria; Alimohammadi, Mohammed; Eltahir, Mohammed et al.

    Flodvåg av långtidssjuka covid-19-patienter väntar

    Part of Dagens Nyheter, p. 5-5, 2020.

  • Eltahir, Mohamed; Persson, Helena; Mangsbo, Sara

    Tumor localized agonistic anti-CD40 therapy and beyond

    Part of Expert Opinion on Biological Therapy, p. 215-217, 2020.

  • Nasi, Aikaterini; McArdle, Stephanie; Gaudernack, Gustav; Westman, Gabriel et al.

    Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

    Part of Toxicology reports, p. 768-771, 2020.

    Open access
  • Ibarra, Cristian; Karlsson, Marie; Codeluppi, Simone; Varas-Godoy, Manuel et al.

    BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling

    Part of Molecular Oncology, p. 202-211, 2019.

    Open access
  • Mangsbo, Sara; Fletcher, Erika; van Maren, Wendy; Redeker, Anke et al.

    Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses

    Part of Molecular Immunology, p. 115-124, 2018.

  • Fletcher, Erika; van Maren, Wendy; Cordfunke, Robert; Dinkelaar, Jasper et al.

    Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System

    Part of Journal of Immunology, p. 87-97, 2018.

  • Fletcher, Erika A. K.; Eltahir, Mohamed; Lindqvist, Frida; Rieth, Jonas et al.

    Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics

    Part of International Immunopharmacology, p. 1-11, 2018.

    Open access
  • Eriksson, Emma; Moreno, R; Milenova, I. Yoanna; Liljenfeldt, L et al.

    Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

    Part of Gene Therapy, p. 92-103, 2017.

    Open access
  • Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Svensson, Emma et al.

    Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

    Part of Journal of Translational Medicine, 2017.

    Open access
  • Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Eriksson, Emma et al.

    Adenovirus-mediated CD40L gene transfer increases teffector/tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

    Part of Scandinavian Journal of Immunology, p. 337-337, 2017.

  • van Hooren, Luuk; Sandin, Linda C.; Moskalev, Igor; Ellmark, Peter et al.

    Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

    Part of European Journal of Immunology, p. 385-393, 2017.

  • Irenaeus, Sandra; Schiza, Aglaia; Mangsbo, Sara M.; Wenthe, Jessica et al.

    Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

    Part of OncoTarget, p. 78573-78587, 2017.

    Open access
  • Ellmark, Peter; Mangsbo, Sara M.; Lindstedt, Malin

    Selective Fc gamma R engagement by human agonistic anti-CD40 antibodies

    Part of Translational Cancer Research, p. S839-S841, 2016.

  • Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

    Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

    Part of British Journal of Cancer, p. 872-880, 2016.

  • van Hooren, Luuk; Georganaki, Maria; Huang, Hua; Mangsbo, Sara M. et al.

    Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

    Part of OncoTarget, p. 50277-50289, 2016.

    Open access
  • Christiansson, Lisa; Söderlund, Stina; Mangsbo, Sara; Hjorth-Hansen, Henrik et al.

    The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

    Part of Molecular Cancer Therapeutics, p. 1181-1191, 2015.

  • Mangsbo, Sara M; Broos, Sissela; Fletcher, Erika; Veitonmäki, Niina et al.

    The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T cell dependent tumor immunity

    Part of Clinical Cancer Research, p. 1115-1126, 2015.

  • Ellmark, P.; Mangsbo, Sara M.; Furebring, C.; Tötterman, Thomas H. et al.

    Kick-starting the cancer-immunity cycle by targeting CD40

    Part of Oncoimmunology, 2015.

  • Vogel, Stephanie; Grabski, Elena; Buschjaeger, Daniela; Klawonn, Frank et al.

    Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells

    Part of Scientific Reports, 2015.

    Open access
  • Christiansson, Lisa; Mustjoki, Satu; Simonsson, Bengt; Olsson-Strömberg, Ulla et al.

    The use of multiplex platforms for absolute and relative protein quantification of clinical material

    Part of EuPA Open Proteomics, p. 37-47, 2014.

  • Liljenfeldt, Lina; Dieterich, Lothar C.; Dimberg, Anna; Mangsbo, Sara M. et al.

    CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

    Part of Cancer Gene Therapy, p. 95-102, 2014.

  • Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica S I et al.

    The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

    Part of Journal of Neuroimmunology, p. 153-159, 2014.

  • Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica et al.

    Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

    Part of Journal of Neuroimmunology, p. 141-141, 2014.

  • Yilmaz-Elis, A Seda; Ramirez, Javier Martin; Asmawidjaja, Patrick; van der Kaa, Jos et al.

    FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis

    Part of Journal of Immunology, p. 5540-5547, 2014.

  • Sandin, Linda; Orlova, Anna; Gustafsson, Erika; Ellmark, Peter et al.

    Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer

    Part of Cancer Immunology Research, p. 80-90, 2014.

    Open access
  • Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

    AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

    Part of Molecular Therapy, p. S247-S247, 2014.

  • Liljenfeldt, Lina; Yu, Di; Chen, Liye; Essand, Magnus et al.

    A Hexon and Fiber-modified Adenovirus Expressing CD40L Improves the Antigen Presentation Capacity of Dendritic Cells

    Part of Journal of immunotherapy (1997), p. 155-162, 2014.

  • Sandin, Linda C.; Eriksson, Fredrik; Ellmark, Peter; Loskog, Angelica S. I. et al.

    Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

    Part of Oncoimmunology, p. e2761-, 2014.

    Open access
  • Sandin, Linda C.; Tötterman, Thomas H.; Mangsbo, Sara M.

    Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer

    Part of Oncoimmunology, 2014.

  • Liljenfeldt, Lina; Svensson, E.; Huang, H.; Dieterich, L. et al.

    AdCD40L immunostimulatory gene therapy shifts the MDSC- and macrophage profiles and promotes T cell infiltration in the tumor microenvironment

    Part of Human Gene Therapy, p. A169-A169, 2013.

  • Burman, Joachim; Fransson, Moa; Tötterman, Thomas H.; Fagius, Jan et al.

    T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis

    Part of Immunology, p. 211-219, 2013.

  • Sharp, Phoebe E H; Martin-Ramirez, Javier; Mangsbo, Sara M; Boross, Peter et al.

    FcγRIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis

    Part of Journal of Immunology, p. 340-348, 2013.

  • Sharp, Phoebe E H; Martin-Ramirez, Javier; Boross, Peter; Mangsbo, Sara M et al.

    Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone

    Part of Molecular Immunology, p. 49-56, 2012.

  • van Montfoort, Nadine; Mangsbo, Sara M; Camps, Marcel G M; van Maren, Wendy W C et al.

    Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo

    Part of European Journal of Immunology, p. 598-606, 2012.

  • van Montfoort, Nadine; 't Hoen, Peter A C; Mangsbo, Sara M; Camps, Marcel G M et al.

    Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells

    Part of Journal of Immunology, p. 92-101, 2012.

  • Lindqvist, Camilla; Christiansson, Lisa; Thörn, Ingrid; Mangsbo, Sara et al.

    Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.

    Part of Immunology, p. 296-306, 2011.

  • Lund, T.; Mangsbo, Sara M.; Scholz, H.; Gjorstrup, P. et al.

    Resolvin E1 Reduces Proinflammatory Markers in Human Pancreatic Islets in vitro

    Part of Experimental and clinical endocrinology & diabetes, p. 237-244, 2010.

  • Malmström, Per-Uno; Loskog, Angelica S. I.; Lindqvist, Camilla A.; Mangsbo, Sara M. et al.

    AdCD40L Immunogene Therapy for Bladder Carcinoma: The First Phase I/IIa Trial

    Part of Clinical Cancer Research, p. 3279-3287, 2010.

  • Mangsbo, Sara; Sandin, Linda; Anger, Kerstin; Korman, Alan et al.

    Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

    Part of Journal of immunotherapy (1997), p. 225-235, 2010.

  • Mangsbo, Sara M; Sanchez, Javier; Anger, Kerstin; Lambris, John D et al.

    Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

    Part of Journal of Immunology, p. 6724-6732, 2009.

  • Eriksson, Fredrik; Tsagozis, Panagiotis; Lundberg, Kajsa; Parsa, Roham et al.

    Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

    Part of Journal of Immunology, p. 3105-3111, 2009.

  • Mangsbo, Sara

    Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Open access
  • Ninalga, Christina; Mangsbo, Sara; Loskog, Angelica; Essand, Magnus et al.

    CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

    Part of Journal of immunotherapy (1997), p. 34-42, 2008.

  • Mangsbo, Sara M; Ninalga, Christina; Essand, Magnus; Loskog, Angelica et al.

    CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

    Part of Journal of immunotherapy (1997), p. 34-42, 2008.