Latest publications

Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Muhammad, Taj; Strömstedt, Adam A.; Gunasekera, Sunithi; Göransson, Ulf

Part of Biomedicines, 2023.

Article in journal

DOI for Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads Download full text (pdf) of Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1

Muhammad, Taj; Houssen, E. Wael; Thomas, Louise; Alexandru-Crivac, Cristina-Nicoleta et al.

Part of Journal of Natural Products, p. 566-573, 2023.

Article in journal

DOI for Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1 Download full text (pdf) of Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1

Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Muhammad, Taj et al.

Part of Journal of Natural Products, p. 52-65, 2023.

Article in journal

DOI for Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens Download full text (pdf) of Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

Rajendran, Sanjeevan; Robertson, Luke P.; Kosgahakumbura, Lakmini; Fernando, Chathurika et al.

Part of Fitoterapia, 2023.

Article in journal

DOI for Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens Download full text (pdf) of Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

On the structures of the penduflorines from Tabernaemontana penduliflora

Beniddir, Mehdi A.; Göransson, Ulf; Robertson, Luke P.

Part of Fitoterapia, 2023.

Article in journal

DOI for On the structures of the penduflorines from Tabernaemontana penduliflora Download full text (pdf) of On the structures of the penduflorines from Tabernaemontana penduliflora

Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia et al.

Part of Pharmaceutics, 2023.

Article in journal

DOI for Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro Download full text (pdf) of Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

KR-12 derivatives endow nanocellulose with antibacterial and anti-inflammatory properties: Role of conjugation chemistry

Blasi Romero, Anna; Ångström, Molly; Franconetti, Antonio; Muhammad, Taj et al.

Part of ACS Applied Materials and Interfaces, p. 24186-24196, 2023.

Article in journal

DOI for KR-12 derivatives endow nanocellulose with antibacterial and anti-inflammatory properties: Role of conjugation chemistry

A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens

Kerr White, John; Mohanty, Soumitra; Muhammad, Taj; de Arriba Sanchez de la Campa, Magdalena et al.

Part of ACS Infectious Diseases, p. 1056-1063, 2023.

Article in journal

DOI for A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens Download full text (pdf) of A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens

The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures

Slazak, Blazej; Jedrzejska, Aleksandra; Badyra, Bogna; Shariatgorji, Reza et al.

Part of PLANTS, 2022.

Article in journal

DOI for The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures Download full text (pdf) of The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures

The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite

Slazak, Blazej; Jedrzejska, Aleksandra; Badyra, Bogna; Sybilska, Anna et al.

Part of Scientific Reports, 2022.

Article in journal

DOI for The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite Download full text (pdf) of The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite

A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens

White, John Kerr; Muhammad, Taj; Alsheim, Emelie; Mohanty, Soumitra et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

Article in journal

DOI for A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens Download full text (pdf) of A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa, Neda; Trobec, Tomaz.; Holland, Darren C.; Slazak, Blazej et al.

Part of Journal of Natural Products, p. 215-224, 2022.

Article in journal

DOI for Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum Download full text (pdf) of Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

Jakobsson, Per-Johan; Robertson, Luke; Welzel, Janika; Zhang, Mingshu et al.

Part of Journal of Internal Medicine, p. 745-763, 2022.

Article, review/survey

DOI for Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis Download full text (pdf) of Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules

Uddin, Shaikh Jamal; Shilpi, Jamil Ahmad; Nahar, Lutfun; Sarker, Satyajit D. et al.

Part of Frontiers in Pharmacology, 2021.

Article in journal

DOI for Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules Download full text (pdf) of Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules

Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Strömstedt, Adam A. et al.

Part of Phytochemistry, 2021.

Article in journal

DOI for Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis Download full text (pdf) of Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis

Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm

Zihad, S. M. Neamul Kabir; Uddin, Shaikh Jamal; Sifat, Nazifa; Lovely, Farhana et al.

Part of Biochemistry and Biophysics Reports, 2021.

Article in journal

DOI for Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm Download full text (pdf) of Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm

Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates

Shcherbakova, A.; Strömstedt, Adam A.; Göransson, Ulf; Gnezdilov, O. et al.

Part of World Journal of Microbiology & Biotechnology, 2021.

Article in journal

DOI for Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates Download full text (pdf) of Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates

Exploring natural products-based cancer therapeutics derived from egyptian flora

El-Seedi, Hesham; Yosri, Nermeen; Khalifa, Shaden A. M.; Guo, Zhiming et al.

Part of Journal of Ethnopharmacology, 2021.

Article, review/survey

DOI for Exploring natural products-based cancer therapeutics derived from egyptian flora

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang, Si-Yu; Zhao, Hui; Xu, Hong-Tao; Han, Xiao-Dong et al.

Part of Frontiers in Pharmacology, 2021.

Article, review/survey

DOI for Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses Download full text (pdf) of Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Functional characterization of the nemertide alpha family of peptide toxins

Jacobsson, Erik; Peigneur, Steve; Andersson, Håkan; Laborde, Quentin et al.

Part of Journal of Natural Products, p. 2121-2128, 2021.

Article in journal

DOI for Functional characterization of the nemertide alpha family of peptide toxins

Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

Steffen, Karin; Laborde, Quentin; Gunasekera, Sunithi; Payne, Colton D. et al.

Part of Journal of Natural Products, p. 3138-3146, 2021.

Article in journal

DOI for Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti Download full text (pdf) of Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

Payne, Colton D.; Vadlamani, Grishma; Hajiaghaalipour, Fatemeh; Muhammad, Taj et al.

Part of RSC CHEMICAL BIOLOGY, p. 1682-1691, 2021.

Article in journal

DOI for Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides Download full text (pdf) of Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Slazak, Blazej; Kaltenböck, Klara; Steffen, Karin; Rogala, Martyna et al.

Part of Scientific Reports, 2021.

Article in journal

DOI for Cyclotide host-defense tailored for species and environments in violets from the Canary Islands Download full text (pdf) of Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Recent insights into chemical and pharmacological studies of bee bread

Khalifa, Shaden A. M.; Elashal, Mohamed; Kieliszek, Marek; Ghazala, Naglaa E. et al.

Part of Trends in Food Science & Technology, p. 300-316, 2020.

Article, review/survey

DOI for Recent insights into chemical and pharmacological studies of bee bread

Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects

Afroz, Mohasana; Akter, Sanzida; Ahmed, Asif; Rouf, Razina et al.

Part of Frontiers in Pharmacology, 2020.

Article, review/survey

DOI for Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects Download full text (pdf) of Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Part of Frontiers in Microbiology, 2020.

Article in journal

DOI for Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability Download full text (pdf) of Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Robertson, Luke P.; Moodie, Lindon W. K.; Holland, Darren C.; Jandér, K. Charlotte et al.

Part of Journal of Natural Products, p. 1305-1308, 2020.

Article in journal

DOI for Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae) Download full text (pdf) of Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

The life cycle of cyclotides: biosynthesis and turnover in plant cells

Slazak, Blazej; Haugmo, Tobias; Badyra, Bogna; Göransson, Ulf

Part of Plant Cell Reports, p. 1359-1367, 2020.

Article in journal

DOI for The life cycle of cyclotides: biosynthesis and turnover in plant cells Download full text (pdf) of The life cycle of cyclotides: biosynthesis and turnover in plant cells

Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

Mohotti, Supun; Rajendran, Sanjeevan; Muhammad, Taj; Strömstedt, Adam A. et al.

Part of Journal of Ethnopharmacology, 2020.

Article in journal

DOI for Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens Download full text (pdf) of Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

The Toxins of Nemertean Worms

Göransson, Ulf; Jacobsson, Erik; Strand, Malin; Andersson, Hakan S.

Part of Toxins, 2019.

Article, review/survey

DOI for The Toxins of Nemertean Worms Download full text (pdf) of The Toxins of Nemertean Worms

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, Shaden A. M.; Elias, Nizar; Farag, Mohamed A.; Chen, Lei et al.

Part of Marine Drugs, 2019.

Article, review/survey

DOI for Marine Natural Products: A Source of Novel Anticancer Drugs Download full text (pdf) of Marine Natural Products: A Source of Novel Anticancer Drugs

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Gunasekera, Sunithi; Fernandes-Cerqueira, Catia; Wennmalm, Stefan; Wahamaa, Heidi et al.

Part of ACS Chemical Biology, p. 1525-1535, 2018.

Article in journal

DOI for Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System

Slazak, Blazej; Kapusta, Malgorzata; Strömstedt, Adam A.; Slomka, Aneta et al.

Part of Frontiers in Plant Science, 2018.

Article in journal

DOI for How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Download full text (pdf) of How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System

Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

Wang, Yan; Lloyd, Katy A.; Gunasekera, Sunithi; Eriksson, Camilla et al.

Part of Arthritis & Rheumatology, 2018.

Article in journal

Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Part of ChemBioChem (Print), p. 931-939, 2018.

Article in journal

DOI for Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Jacobsson, Erik; Andersson, Håkan S.; Strand, Malin; Peigneur, Steve et al.

Part of Scientific Reports, 2018.

Article in journal

DOI for Peptide ion channel toxins from the bootlace worm, the longest animal on Earth Download full text (pdf) of Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Single-step purification of cyclotides using affinity chromatography

Uddin, Shaikh Jamal; Muhammad, Taj; Shafiullah, Md; Slazak, Blazej et al.

Part of Biopolymers, 2017.

Article in journal

DOI for Single-step purification of cyclotides using affinity chromatography

Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides

Malik, Sohaib Zafar; Linkevicius, Marius; Göransson, Ulf; Andersson, Dan I

Part of Antimicrobial Agents and Chemotherapy, 2017.

Article in journal

DOI for Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides Download full text (pdf) of Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides

The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery

Kirkpatrick, Christine L.; Broberg, Christopher A.; McCool, Elijah N.; Lee, Woo Jean et al.

Part of Analytical Chemistry, p. 1194-1201, 2017.

Article in journal

DOI for The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Hellinger, Roland; Thell, Kathrin; Vasileva, Mina; Muhammad, Taj et al.

Part of Frontiers in Chemistry, 2017.

Article in journal

DOI for Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins Download full text (pdf) of Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola)

Park, Sungkyu; Yoo, Ki-Oug; Marcussen, Thomas; Backlund, Anders et al.

Part of Frontiers in Plant Science, 2017.

Article in journal

DOI for Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola) Download full text (pdf) of Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola)

Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra

Strömstedt, Adam A.; Park, Sungkyu; Burman, Robert; Göransson, Ulf

Part of Biochimica et Biophysica Acta - Biomembranes, p. 1986-2000, 2017.

Article in journal

DOI for Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra

35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters.

Bohlin, Lars; Cárdenas, Paco; Backlund, Anders; Göransson, Ulf

Part of Progress in molecular and subcellular biology, p. 1-34, 2017.

Article in journal

DOI for 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters.

Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead

Muhammad, Taj; Gunasekera, Sunithi; Strömstedt, Adam A.; Göransson, Ulf

Part of Journal of Peptide Science, p. S184-S186, 2016.

Article in journal

DOI for Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead

Anti-Citrullinated Peptide Antibody Inhibitors Based On Sunflower Trypsin Inhibitor-1 Scaffold For Potential Anti-Rheumatoid Arthritis Activity

Gunasekera, Sunithi; Fernandes-Cerqueira, C.; Eriksson, Camilla; Jakobsson, P-J et al.

Part of Journal of Peptide Science, p. S170-S170, 2016.

Article in journal

DOI for Anti-Citrullinated Peptide Antibody Inhibitors Based On Sunflower Trypsin Inhibitor-1 Scaffold For Potential Anti-Rheumatoid Arthritis Activity

Bacterial Resistance To A Cyclic Antimicrobial Peptide

Malik, Sohaib Zafar; Göransson, Ulf; Andersson, Dan I

Part of Journal of Peptide Science, p. S180-S180, 2016.

Article in journal

DOI for Bacterial Resistance To A Cyclic Antimicrobial Peptide

Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis.

Thell, Kathrin; Hellinger, Roland; Sahin, Emine; Michenthaler, Paul et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3960-3965, 2016.

Article in journal

DOI for Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis.

Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket

Strömstedt, Adam A.; Kristiansen, Per Eugen; Gunasekera, Sunithi; Grob, Nathalie et al.

Part of Biochimica et Biophysica Acta, p. 1317-1327, 2016.

Article in journal

DOI for Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket

The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive?

Strand, Malin; Hedström, Martin; Seth, Henrik; McEvoy, Eric G et al.

Part of Marine Drugs, 2016.

Article in journal

DOI for The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive? Download full text (pdf) of The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive?

Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report

Craik, David J.; Shim, Youn Young; Göransson, Ulf; Moss, Gerard P. et al.

Part of Biopolymers, p. 917-924, 2016.

Article in journal

DOI for Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report