Latest publications

Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Muhammad, Taj; Strömstedt, Adam A.; Gunasekera, Sunithi; Göransson, Ulf

Part of Biomedicines, 2023.

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DOI for Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads Download full text (pdf) of Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1

Muhammad, Taj; Houssen, E. Wael; Thomas, Louise; Alexandru-Crivac, Cristina-Nicoleta et al.

Part of Journal of Natural Products, p. 566-573, 2023.

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DOI for Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1 Download full text (pdf) of Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1

Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Muhammad, Taj et al.

Part of Journal of Natural Products, p. 52-65, 2023.

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DOI for Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens Download full text (pdf) of Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

Rajendran, Sanjeevan; Robertson, Luke P.; Kosgahakumbura, Lakmini; Fernando, Chathurika et al.

Part of Fitoterapia, 2023.

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DOI for Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens Download full text (pdf) of Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

On the structures of the penduflorines from Tabernaemontana penduliflora

Beniddir, Mehdi A.; Göransson, Ulf; Robertson, Luke P.

Part of Fitoterapia, 2023.

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DOI for On the structures of the penduflorines from Tabernaemontana penduliflora Download full text (pdf) of On the structures of the penduflorines from Tabernaemontana penduliflora

The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures

Slazak, Blazej; Jedrzejska, Aleksandra; Badyra, Bogna; Shariatgorji, Reza et al.

Part of PLANTS, 2022.

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DOI for The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures Download full text (pdf) of The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures

The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite

Slazak, Blazej; Jedrzejska, Aleksandra; Badyra, Bogna; Sybilska, Anna et al.

Part of Scientific Reports, 2022.

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DOI for The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite Download full text (pdf) of The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite

Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay

Simon, Alexandra; Nghiem, Kim Szofi; Gampe, Nora; Garadi, Zsofia et al.

Part of Pharmaceutics, 2022.

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DOI for Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay Download full text (pdf) of Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay

A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens

White, John Kerr; Muhammad, Taj; Alsheim, Emelie; Mohanty, Soumitra et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

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DOI for A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens Download full text (pdf) of A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa, Neda; Trobec, Tomaz.; Holland, Darren C.; Slazak, Blazej et al.

Part of Journal of Natural Products, p. 215-224, 2022.

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DOI for Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum Download full text (pdf) of Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

Jakobsson, Per-Johan; Robertson, Luke; Welzel, Janika; Zhang, Mingshu et al.

Part of Journal of Internal Medicine, p. 745-763, 2022.

Article, review/survey

DOI for Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis Download full text (pdf) of Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system

Gampe, Nora; David, Dominika Noemi; Takacs-Novak, Krisztina; Backlund, Anders et al.

Part of PLOS ONE, 2022.

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DOI for In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system Download full text (pdf) of In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system

Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules

Uddin, Shaikh Jamal; Shilpi, Jamil Ahmad; Nahar, Lutfun; Sarker, Satyajit D. et al.

Part of Frontiers in Pharmacology, 2021.

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DOI for Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules Download full text (pdf) of Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules

Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Strömstedt, Adam A. et al.

Part of Phytochemistry, 2021.

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DOI for Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis Download full text (pdf) of Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis

Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm

Zihad, S. M. Neamul Kabir; Uddin, Shaikh Jamal; Sifat, Nazifa; Lovely, Farhana et al.

Part of Biochemistry and Biophysics Reports, 2021.

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DOI for Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm Download full text (pdf) of Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm

Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates

Shcherbakova, A.; Strömstedt, Adam A.; Göransson, Ulf; Gnezdilov, O. et al.

Part of World Journal of Microbiology & Biotechnology, 2021.

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DOI for Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates Download full text (pdf) of Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates

Exploring natural products-based cancer therapeutics derived from egyptian flora

El-Seedi, Hesham; Yosri, Nermeen; Khalifa, Shaden A. M.; Guo, Zhiming et al.

Part of Journal of Ethnopharmacology, 2021.

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DOI for Exploring natural products-based cancer therapeutics derived from egyptian flora

Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities

Purnomo, Kartiko Arif; Korinek, Michal; Tsai, Yi-Hong; Hu, Hao-Chun et al.

Part of Journal of Agricultural and Food Chemistry, p. 11856-11866, 2021.

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DOI for Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang, Si-Yu; Zhao, Hui; Xu, Hong-Tao; Han, Xiao-Dong et al.

Part of Frontiers in Pharmacology, 2021.

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DOI for Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses Download full text (pdf) of Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Functional characterization of the nemertide alpha family of peptide toxins

Jacobsson, Erik; Peigneur, Steve; Andersson, Håkan; Laborde, Quentin et al.

Part of Journal of Natural Products, p. 2121-2128, 2021.

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DOI for Functional characterization of the nemertide alpha family of peptide toxins

Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

Steffen, Karin; Laborde, Quentin; Gunasekera, Sunithi; Payne, Colton D. et al.

Part of Journal of Natural Products, p. 3138-3146, 2021.

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DOI for Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti Download full text (pdf) of Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

Payne, Colton D.; Vadlamani, Grishma; Hajiaghaalipour, Fatemeh; Muhammad, Taj et al.

Part of RSC CHEMICAL BIOLOGY, p. 1682-1691, 2021.

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DOI for Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides Download full text (pdf) of Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

Stenholm, Åke; Backlund, Anders; Holmström, Sara; Backlund, Maria et al.

Part of PLOS ONE, 2021.

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DOI for Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media Download full text (pdf) of Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Slazak, Blazej; Kaltenböck, Klara; Steffen, Karin; Rogala, Martyna et al.

Part of Scientific Reports, 2021.

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DOI for Cyclotide host-defense tailored for species and environments in violets from the Canary Islands Download full text (pdf) of Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Recent insights into chemical and pharmacological studies of bee bread

Khalifa, Shaden A. M.; Elashal, Mohamed; Kieliszek, Marek; Ghazala, Naglaa E. et al.

Part of Trends in Food Science & Technology, p. 300-316, 2020.

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DOI for Recent insights into chemical and pharmacological studies of bee bread

Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis

Alajlani, Muaaz Mutaz; Backlund, Anders

Part of Molecules, 2020.

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DOI for Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis Download full text (pdf) of Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis

Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects

Afroz, Mohasana; Akter, Sanzida; Ahmed, Asif; Rouf, Razina et al.

Part of Frontiers in Pharmacology, 2020.

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DOI for Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects Download full text (pdf) of Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Part of Frontiers in Microbiology, 2020.

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DOI for Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability Download full text (pdf) of Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Robertson, Luke P.; Moodie, Lindon W. K.; Holland, Darren C.; Jandér, K. Charlotte et al.

Part of Journal of Natural Products, p. 1305-1308, 2020.

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DOI for Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae) Download full text (pdf) of Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Revisiting the phylogeny of Dipsacales: New insights from phylogenomic analyses of complete plastomic sequences

Xiang, Chun‐Lei; Dong, Hong‐Jin; Landrein, Sven; Zhao, Fei et al.

Part of Journal of Systematics and Evolution, p. 103-117, 2020.

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DOI for Revisiting the phylogeny of Dipsacales: New insights from phylogenomic analyses of complete plastomic sequences

The life cycle of cyclotides: biosynthesis and turnover in plant cells

Slazak, Blazej; Haugmo, Tobias; Badyra, Bogna; Göransson, Ulf

Part of Plant Cell Reports, p. 1359-1367, 2020.

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DOI for The life cycle of cyclotides: biosynthesis and turnover in plant cells Download full text (pdf) of The life cycle of cyclotides: biosynthesis and turnover in plant cells

Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells

Henz Ryen, Astrid; Goels, Thomas; Steinmetz, Julia; Tahir, Ammar et al.

Part of Phytochemistry Letters, p. 6-11, 2020.

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DOI for Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells

Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

Mohotti, Supun; Rajendran, Sanjeevan; Muhammad, Taj; Strömstedt, Adam A. et al.

Part of Journal of Ethnopharmacology, 2020.

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DOI for Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens Download full text (pdf) of Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

The Toxins of Nemertean Worms

Göransson, Ulf; Jacobsson, Erik; Strand, Malin; Andersson, Hakan S.

Part of Toxins, 2019.

Article, review/survey

DOI for The Toxins of Nemertean Worms Download full text (pdf) of The Toxins of Nemertean Worms

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, Shaden A. M.; Elias, Nizar; Farag, Mohamed A.; Chen, Lei et al.

Part of Marine Drugs, 2019.

Article, review/survey

DOI for Marine Natural Products: A Source of Novel Anticancer Drugs Download full text (pdf) of Marine Natural Products: A Source of Novel Anticancer Drugs

Charting Angiosperm Chemistry: Evolutionary Perspective on Specialized Metabolites Reflected in Chemical Property Space

Henz Ryen, Astrid; Backlund, Anders

Part of Journal of Natural Products, p. 798-812, 2019.

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DOI for Charting Angiosperm Chemistry: Evolutionary Perspective on Specialized Metabolites Reflected in Chemical Property Space

Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum

Xu, Jing-Hao; Lai, Kuei-Hung; Su, Yin-Di; Chang, Yu-Chia et al.

Part of Marine Drugs, 2018.

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DOI for Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum Download full text (pdf) of Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Gunasekera, Sunithi; Fernandes-Cerqueira, Catia; Wennmalm, Stefan; Wahamaa, Heidi et al.

Part of ACS Chemical Biology, p. 1525-1535, 2018.

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DOI for Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System

Slazak, Blazej; Kapusta, Malgorzata; Strömstedt, Adam A.; Slomka, Aneta et al.

Part of Frontiers in Plant Science, 2018.

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DOI for How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Download full text (pdf) of How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System

Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

Wang, Yan; Lloyd, Katy A.; Gunasekera, Sunithi; Eriksson, Camilla et al.

Part of Arthritis & Rheumatology, 2018.

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Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Part of ChemBioChem (Print), p. 931-939, 2018.

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DOI for Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Jacobsson, Erik; Andersson, Håkan S.; Strand, Malin; Peigneur, Steve et al.

Part of Scientific Reports, 2018.

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DOI for Peptide ion channel toxins from the bootlace worm, the longest animal on Earth Download full text (pdf) of Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Single-step purification of cyclotides using affinity chromatography

Uddin, Shaikh Jamal; Muhammad, Taj; Shafiullah, Md; Slazak, Blazej et al.

Part of Biopolymers, 2017.

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DOI for Single-step purification of cyclotides using affinity chromatography

Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27

Yang, Lu; Chai, Cheng-Zhi; Yan, Yan; Duan, Ying-Dan et al.

Part of Molecules, 2017.

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DOI for Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27 Download full text (pdf) of Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27

Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides

Malik, Sohaib Zafar; Linkevicius, Marius; Göransson, Ulf; Andersson, Dan I

Part of Antimicrobial Agents and Chemotherapy, 2017.

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DOI for Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides Download full text (pdf) of Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides

The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery

Kirkpatrick, Christine L.; Broberg, Christopher A.; McCool, Elijah N.; Lee, Woo Jean et al.

Part of Analytical Chemistry, p. 1194-1201, 2017.

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DOI for The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery

Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP

Korinek, Michal; Tsai, Yi-Hong; El-Shazly, Mohamed; Lai, Kuei-Hung et al.

Part of Frontiers in Pharmacology, 2017.

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DOI for Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP Download full text (pdf) of Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Hellinger, Roland; Thell, Kathrin; Vasileva, Mina; Muhammad, Taj et al.

Part of Frontiers in Chemistry, 2017.

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DOI for Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins Download full text (pdf) of Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola)

Park, Sungkyu; Yoo, Ki-Oug; Marcussen, Thomas; Backlund, Anders et al.

Part of Frontiers in Plant Science, 2017.

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DOI for Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola) Download full text (pdf) of Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola)

Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra

Strömstedt, Adam A.; Park, Sungkyu; Burman, Robert; Göransson, Ulf

Part of Biochimica et Biophysica Acta - Biomembranes, p. 1986-2000, 2017.

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DOI for Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra