Publications

Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units

Sarangi, Sohan; Frenning, Göran

Part of Powder Technology, 2023.

Article in journal

DOI for Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units Download full text (pdf) of Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units

A new modelling approach for dissolution of polydisperse powders

van der Zwaan, Ires; Frenning, Göran

Part of International Journal of Pharmaceutics, 2023.

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DOI for A new modelling approach for dissolution of polydisperse powders Download full text (pdf) of A new modelling approach for dissolution of polydisperse powders

Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, 2022.

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DOI for Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation Download full text (pdf) of Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation

Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose

Tofiq, Maryam; Nordström, Josefina; Persson, Ann-Sofie; Alderborn, Göran

Part of Powder Technology, 2022.

Article in journal

DOI for Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose Download full text (pdf) of Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose

Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders

Tofiq, Maryam; Nordström, Josefina; Persson, Ann-Sofie; Alderborn, Göran

Part of Powder Technology, 2022.

Article in journal

DOI for Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders Download full text (pdf) of Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders

Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. I. Experimental comparison

Persson, Ann-Sofie; Pazesh, Samaneh; Alderborn, Göran

Part of Pharmaceutical development and technology (Print), p. 319-330, 2022.

Article in journal

DOI for Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. I. Experimental comparison Download full text (pdf) of Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. I. Experimental comparison

Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness

Andersson, Sara B. E.; Frenning, Göran; Alderborn, Göran; Gråsjö, Johan

Part of European journal of pharmaceutics and biopharmaceutics, p. 1-10, 2022.

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DOI for Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness Download full text (pdf) of Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness

Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial

Holmbäck, Ulf; Gruden, Stefan; Litorp, Helena; Willhems, Daniel et al.

Part of Obesity, p. 2222-2232, 2022.

Article in journal

DOI for Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial Download full text (pdf) of Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial

Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation

Frenning, Göran

Part of COMPUTATIONAL PARTICLE MECHANICS, p. 1105-1118, 2022.

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DOI for Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation Download full text (pdf) of Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation

Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model

van der Zwaan, Irès; Franek, Frans; Fransson, Rebecca; Tehler, Ulrika et al.

Part of Molecular Pharmaceutics, p. 3114-3124, 2022.

Article in journal

DOI for Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model Download full text (pdf) of Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model

Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities

Andersson, Sara B. E.; Frenning, Göran; Alderborn, Göran

Part of Pharmaceutics, 2021.

Article in journal

DOI for Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities Download full text (pdf) of Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities

Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach

Nikjoo, Dariush; van der Zwaan, Ires; Brülls, Mikael; Tehler, Ulrika et al.

Part of Pharmaceutics, 2021.

Article in journal

DOI for Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach Download full text (pdf) of Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach

On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics: X, 2021.

Article in journal

DOI for On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients Download full text (pdf) of On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose.

Grudén, Stefan; Forslund, Anders; Alderborn, Göran; Söderhäll, Arvid et al.

Part of Clinical Pharmacology in Drug Development, p. 1242-1247, 2021.

Article in journal

DOI for Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose. Download full text (pdf) of Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose.

Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Powder Technology, p. 299-305, 2021.

Article in journal

DOI for Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation Download full text (pdf) of Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation

Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Powder Technology, p. 230-239, 2021.

Article in journal

DOI for Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study Download full text (pdf) of Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study

Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael et al.

Part of Journal of Colloid and Interface Science, p. 92-100, 2020.

Article in journal

DOI for Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles Download full text (pdf) of Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

Part of Obesity Science & Practice, p. 313-323, 2020.

Article in journal

DOI for Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity Download full text (pdf) of Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Chemical Engineering Science: X, 2020.

Article in journal

DOI for Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling Download full text (pdf) of Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs

Frenning, Göran; van der Zwaan, Ires; Franek, Frans; Fransson, Rebecca et al.

Part of Molecular Pharmaceutics, p. 2426-2434, 2020.

Article in journal

DOI for Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs Download full text (pdf) of Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs

Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

Jonsson, Henrik; Öhman-Mägi, Caroline; Alderborn, Göran; Isaksson, Per et al.

Part of International Journal of Pharmaceutics, p. 130-137, 2019.

Article in journal

DOI for Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles

Jonsson, Henrik; Alderborn, Göran; Frenning, Göran

Part of Powder Technology, p. 74-81, 2019.

Article in journal

DOI for Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles

Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern

Pazesh, Samaneh; Persson, Ann-Sofie; Alderborn, Göran

Part of International Journal of Pharmaceutics: X, 2019.

Article in journal

DOI for Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern Download full text (pdf) of Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern

Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, p. 148-160, 2019.

Article in journal

DOI for Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model Download full text (pdf) of Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

Milling induced amorphisation and recrystallization of alpha-lactose monohydrate

Tejedor, Maria Badal; Pazesh, Samaneh; Nordgren, Niklas; Schuleit, Michael et al.

Part of International Journal of Pharmaceutics, p. 140-147, 2018.

Article in journal

DOI for Milling induced amorphisation and recrystallization of alpha-lactose monohydrate

A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression

Persson, Ann-Sofie; Alderborn, Göran

Part of European journal of pharmaceutics and biopharmaceutics, p. 28-37, 2018.

Article in journal

DOI for A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression Download full text (pdf) of A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression

Effect of milling on the plastic and the elastic stiffness of lactose particles

Pazesh, Samaneh; Persson, Ann-Sofie; Berggren, Jonas; Alderborn, Göran

Part of European Journal of Pharmaceutical Sciences, p. 138-145, 2018.

Article in journal

DOI for Effect of milling on the plastic and the elastic stiffness of lactose particles Download full text (pdf) of Effect of milling on the plastic and the elastic stiffness of lactose particles

Powder Compression Properties of Paracetamol, Paracetamol Hydrochloride, and Paracetamol Cocrystals and Coformers

Persson, Ann-Sofie; Ahmed, Hamzah; Velaga, Sitaram; Alderborn, Göran

Part of Journal of Pharmaceutical Sciences, p. 1920-1927, 2018.

Article in journal

DOI for Powder Compression Properties of Paracetamol, Paracetamol Hydrochloride, and Paracetamol Cocrystals and Coformers

Determination of interfacial amorphicity in functional powders

Tejedor, Maria Badal; Nordgren, Niklas; Schuleit, Michael; Pazesh, Samaneh et al.

Part of Abstracts of Papers of the American Chemical Society, 2018.

Article in journal

Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, p. 143-156, 2018.

Article in journal

DOI for Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers

Compressibility and tablet forming ability of bimodal granule mixtures: Experiments and DEM simulations

Nordström, Josefina; Alderborn, Göran; Frenning, Göran

Part of International Journal of Pharmaceutics, p. 120-131, 2018.

Article in journal

DOI for Compressibility and tablet forming ability of bimodal granule mixtures: Experiments and DEM simulations

Determination of Interfacial Amorphicity in Functional Powders

Tejedor, Maria Badal; Nordgren, Niklas; Schuleit, Michael; Pazesh, Samaneh et al.

Part of Langmuir, p. 920-926, 2017.

Article in journal

DOI for Determination of Interfacial Amorphicity in Functional Powders

Comminution-amorphisation relationships during ball milling of lactose at different milling conditions

Pazesh, Samaneh; Gråsjö, Johan; Berggren, Jonas; Alderborn, Göran

Part of International Journal of Pharmaceutics, p. 215-227, 2017.

Article in journal

DOI for Comminution-amorphisation relationships during ball milling of lactose at different milling conditions Download full text (pdf) of Comminution-amorphisation relationships during ball milling of lactose at different milling conditions

Peptide loaded microgels as antimicrobial surface coatings

Nyström, Lina; Nordström, Randi; Frenning, Göran; Saunders, Brian et al.

Part of Abstracts of Papers of the American Chemical Society, 2017.

Article in journal

Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions

Jonsson, Henrik; Gråsjö, Johan; Frenning, Göran

Part of Powder Technology, p. 347-355, 2017.

Article in journal

DOI for Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions Download full text (pdf) of Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017.

Article in journal

DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system Download full text (pdf) of Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Considerations on the quantitative analysis of apparent amorphicity of milled lactose by Raman spectroscopy

Pazesh, Samaneh; Lazorova, Lucia; Berggren, Jonas; Alderborn, Göran et al.

Part of International Journal of Pharmaceutics, p. 488-504, 2016.

Article in journal

DOI for Considerations on the quantitative analysis of apparent amorphicity of milled lactose by Raman spectroscopy Download full text (pdf) of Considerations on the quantitative analysis of apparent amorphicity of milled lactose by Raman spectroscopy

Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Persson, Ann-Sofie; Nordström, Josefina; Frenning, Göran; Alderborn, Göran

Part of Chemical engineering research & design, p. 183-191, 2016.

Article in journal

DOI for Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Electrostatic Swelling Transitions in Surface-Bound Microgels

Nyström, Lina; Alvarez-Asencio, Ruben; Frenning, Göran; Saunders, Brian R. et al.

Part of ACS Applied Materials and Interfaces, p. 27129-27139, 2016.

Article in journal

DOI for Electrostatic Swelling Transitions in Surface-Bound Microgels

Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression

Jonsson, Henrik; Frenning, Göran

Part of Powder Technology, p. 79-87, 2016.

Article in journal

DOI for Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression Download full text (pdf) of Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression

Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions

Frenning, Göran

Part of MethodsX, p. 79-90, 2015.

Article in journal

DOI for Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions Download full text (pdf) of Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions

Inhibition of Recrystallization of Amorphous Lactose in Nanocomposites Formed by Spray-Drying

Hellrup, Joel; Alderborn, Göran; Mahlin, Denny

Part of Journal of Pharmaceutical Sciences, p. 3760-3769, 2015.

Article in journal

DOI for Inhibition of Recrystallization of Amorphous Lactose in Nanocomposites Formed by Spray-Drying

An apparatus for confined triaxial testing of single particles

Jonsson, Henrik; Gråsjö, Johan; Nordström, Josefina; Johansson, Niklas et al.

Part of Powder Technology, p. 121-127, 2015.

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DOI for An apparatus for confined triaxial testing of single particles Download full text (pdf) of An apparatus for confined triaxial testing of single particles

The Granule Porosity Controls the Loss of Compactibility for Both Dry- and Wet-Processed Cellulose Granules but at Different Rate

Nordström, Josefina; Alderborn, Göran

Part of Journal of Pharmaceutical Sciences, p. 2029-2039, 2015.

Article in journal

DOI for The Granule Porosity Controls the Loss of Compactibility for Both Dry- and Wet-Processed Cellulose Granules but at Different Rate

Towards a mechanistic contact model for elastoplastic particles at high relative densities

Frenning, Göran

Part of Finite elements in analysis and design (Print), p. 56-60, 2015.

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DOI for Towards a mechanistic contact model for elastoplastic particles at high relative densities Download full text (pdf) of Towards a mechanistic contact model for elastoplastic particles at high relative densities

An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model

Persson, Ann-Sofie; Frenning, Göran

Part of Powder Technology, p. 257-264, 2015.

Article in journal

DOI for An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model Download full text (pdf) of An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model

Chain and Pore-Blocking Effects on Matrix Degradation in Protein-Loaded Microgels

Widenbring, Ronja; Frenning, Göran; Malmsten, Martin

Part of Biomacromolecules, p. 3671-3678, 2014.

Article in journal

DOI for Chain and Pore-Blocking Effects on Matrix Degradation in Protein-Loaded Microgels

The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

Höckerfelt, Mina Heidarian; Alderborn, Göran

Part of International Journal of Pharmaceutics, p. 326-333, 2014.

Article in journal

DOI for The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

Factors Affecting Enzymatic Degradation of Microgel-Bound Peptides

Mansson, Ronja; Frenning, Göran; Malmsten, Martin

Part of Biomacromolecules, p. 2317-2325, 2013.

Article in journal

DOI for Factors Affecting Enzymatic Degradation of Microgel-Bound Peptides

The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation

Persson, Ann-Sofie; Frenning, Göran

Part of European Journal of Pharmaceutical Sciences, p. 241-250, 2013.

Article in journal

DOI for The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation Download full text (pdf) of The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation