Latest publications

Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units

Sarangi, Sohan; Frenning, Göran

Part of Powder Technology, 2023.

Article in journal

DOI for Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units Download full text (pdf) of Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units

A new modelling approach for dissolution of polydisperse powders

van der Zwaan, Ires; Frenning, Göran

Part of International Journal of Pharmaceutics, 2023.

Article in journal

DOI for A new modelling approach for dissolution of polydisperse powders Download full text (pdf) of A new modelling approach for dissolution of polydisperse powders

A Voronoi strain-based method for granular materials and continua

Frenning, Göran

Part of Computational particle mechanics, p. 427-443, 2023.

Article in journal

DOI for A Voronoi strain-based method for granular materials and continua Download full text (pdf) of A Voronoi strain-based method for granular materials and continua

On the thermodynamic consistency of the Drucker-Prager Cap model: Modification of the plastic potential and analysis of unloading

Frenning, Göran

Part of Powder Technology, 2023.

Article in journal

DOI for On the thermodynamic consistency of the Drucker-Prager Cap model: Modification of the plastic potential and analysis of unloading Download full text (pdf) of On the thermodynamic consistency of the Drucker-Prager Cap model: Modification of the plastic potential and analysis of unloading

Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures

Sarangi, Sohan; Simonsson, Anna; Frenning, Göran

Part of European journal of pharmaceutics and biopharmaceutics, p. 107-119, 2023.

Article in journal

DOI for Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures Download full text (pdf) of Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures

Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate

Nikjoo, Dariush; van der Zwaan, Ires; Rudén, Jonas; Frenning, Göran

Part of International Journal of Pharmaceutics, 2023.

Article in journal

DOI for Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate Download full text (pdf) of Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate

Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, 2022.

Article in journal

DOI for Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation Download full text (pdf) of Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation

Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness

Andersson, Sara B. E.; Frenning, Göran; Alderborn, Göran; Gråsjö, Johan

Part of European journal of pharmaceutics and biopharmaceutics, p. 1-10, 2022.

Article in journal

DOI for Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness Download full text (pdf) of Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness

Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation

Frenning, Göran

Part of COMPUTATIONAL PARTICLE MECHANICS, p. 1105-1118, 2022.

Article in journal

DOI for Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation Download full text (pdf) of Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation

Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model

van der Zwaan, Irès; Franek, Frans; Fransson, Rebecca; Tehler, Ulrika et al.

Part of Molecular Pharmaceutics, p. 3114-3124, 2022.

Article in journal

DOI for Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model Download full text (pdf) of Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model

Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities

Andersson, Sara B. E.; Frenning, Göran; Alderborn, Göran

Part of Pharmaceutics, 2021.

Article in journal

DOI for Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities Download full text (pdf) of Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities

Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach

Nikjoo, Dariush; van der Zwaan, Ires; Brülls, Mikael; Tehler, Ulrika et al.

Part of Pharmaceutics, 2021.

Article in journal

DOI for Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach Download full text (pdf) of Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach

Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Powder Technology, p. 299-305, 2021.

Article in journal

DOI for Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation Download full text (pdf) of Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation

Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Powder Technology, p. 230-239, 2021.

Article in journal

DOI for Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study Download full text (pdf) of Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study

On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, 2021.

Article in journal

DOI for On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients Download full text (pdf) of On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael et al.

Part of Journal of Colloid and Interface Science, p. 92-100, 2020.

Article in journal

DOI for Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles Download full text (pdf) of Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Part of Chemical Engineering Science: X, 2020.

Article in journal

DOI for Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling Download full text (pdf) of Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs

Frenning, Göran; van der Zwaan, Ires; Franek, Frans; Fransson, Rebecca et al.

Part of Molecular Pharmaceutics, p. 2426-2434, 2020.

Article in journal

DOI for Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs Download full text (pdf) of Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs

Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

Jonsson, Henrik; Öhman-Mägi, Caroline; Alderborn, Göran; Isaksson, Per et al.

Part of International Journal of Pharmaceutics, p. 130-137, 2019.

Article in journal

DOI for Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles

Jonsson, Henrik; Alderborn, Göran; Frenning, Göran

Part of Powder Technology, p. 74-81, 2019.

Article in journal

DOI for Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles

Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, p. 148-160, 2019.

Article in journal

DOI for Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model Download full text (pdf) of Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre et al.

Part of International Journal of Pharmaceutics, p. 143-156, 2018.

Article in journal

DOI for Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers

Compressibility and tablet forming ability of bimodal granule mixtures: Experiments and DEM simulations

Nordström, Josefina; Alderborn, Göran; Frenning, Göran

Part of International Journal of Pharmaceutics, p. 120-131, 2018.

Article in journal

DOI for Compressibility and tablet forming ability of bimodal granule mixtures: Experiments and DEM simulations

Peptide loaded microgels as antimicrobial surface coatings

Nyström, Lina; Nordström, Randi; Frenning, Göran; Saunders, Brian et al.

Part of Abstracts of Papers of the American Chemical Society, 2017.

Article in journal

Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions

Jonsson, Henrik; Gråsjö, Johan; Frenning, Göran

Part of Powder Technology, p. 347-355, 2017.

Article in journal

DOI for Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions Download full text (pdf) of Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017.

Article in journal

DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system Download full text (pdf) of Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Persson, Ann-Sofie; Nordström, Josefina; Frenning, Göran; Alderborn, Göran

Part of Chemical engineering research & design, p. 183-191, 2016.

Article in journal

DOI for Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations

Electrostatic Swelling Transitions in Surface-Bound Microgels

Nyström, Lina; Alvarez-Asencio, Ruben; Frenning, Göran; Saunders, Brian R. et al.

Part of ACS Applied Materials and Interfaces, p. 27129-27139, 2016.

Article in journal

DOI for Electrostatic Swelling Transitions in Surface-Bound Microgels

Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression

Jonsson, Henrik; Frenning, Göran

Part of Powder Technology, p. 79-87, 2016.

Article in journal

DOI for Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression Download full text (pdf) of Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression

Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions

Frenning, Göran

Part of MethodsX, p. 79-90, 2015.

Article in journal

DOI for Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions Download full text (pdf) of Efficient Voronoi volume estimation for DEM simulations of granular materials under confined conditions

An apparatus for confined triaxial testing of single particles

Jonsson, Henrik; Gråsjö, Johan; Nordström, Josefina; Johansson, Niklas et al.

Part of Powder Technology, p. 121-127, 2015.

Article in journal

DOI for An apparatus for confined triaxial testing of single particles Download full text (pdf) of An apparatus for confined triaxial testing of single particles

Towards a mechanistic contact model for elastoplastic particles at high relative densities

Frenning, Göran

Part of Finite elements in analysis and design (Print), p. 56-60, 2015.

Article in journal

DOI for Towards a mechanistic contact model for elastoplastic particles at high relative densities Download full text (pdf) of Towards a mechanistic contact model for elastoplastic particles at high relative densities

An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model

Persson, Ann-Sofie; Frenning, Göran

Part of Powder Technology, p. 257-264, 2015.

Article in journal

DOI for An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model Download full text (pdf) of An experimental evaluation of discrete element simulations of confined powder compression using an extended truncated-sphere model

Chain and Pore-Blocking Effects on Matrix Degradation in Protein-Loaded Microgels

Widenbring, Ronja; Frenning, Göran; Malmsten, Martin

Part of Biomacromolecules, p. 3671-3678, 2014.

Article in journal

DOI for Chain and Pore-Blocking Effects on Matrix Degradation in Protein-Loaded Microgels

Factors Affecting Enzymatic Degradation of Microgel-Bound Peptides

Mansson, Ronja; Frenning, Göran; Malmsten, Martin

Part of Biomacromolecules, p. 2317-2325, 2013.

Article in journal

DOI for Factors Affecting Enzymatic Degradation of Microgel-Bound Peptides

The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation

Persson, Ann-Sofie; Frenning, Göran

Part of European Journal of Pharmaceutical Sciences, p. 241-250, 2013.

Article in journal

DOI for The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation Download full text (pdf) of The influence of rolling friction on the shear behaviour of non-cohesive pharmaceutical granules: An experimental and numerical investigation

The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

Nordström, Josefina; Persson, Ann-Sofie; Lazorova, Lucia; Frenning, Göran et al.

Part of International Journal of Pharmaceutics, p. 3-12, 2013.

Article in journal

DOI for The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction Download full text (pdf) of The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

Towards a mechanistic model for the interaction between plastically deforming particles under confined conditions: A numerical and analytical analysis

Frenning, Göran

Part of Materials letters (General ed.), p. 365-368, 2013.

Article in journal

DOI for Towards a mechanistic model for the interaction between plastically deforming particles under confined conditions: A numerical and analytical analysis Download full text (pdf) of Towards a mechanistic model for the interaction between plastically deforming particles under confined conditions: A numerical and analytical analysis

A comparison between two powder compaction parameters of plasticity: The effective medium A parameter and the Heckel 1/K parameter

Mahmoodi, Foad; Klevan, Ingvild; Nordström, Josefina; Alderborn, Göran et al.

Part of International Journal of Pharmaceutics, p. 295-299, 2013.

Article in journal

DOI for A comparison between two powder compaction parameters of plasticity: The effective medium A parameter and the Heckel 1/K parameter Download full text (pdf) of A comparison between two powder compaction parameters of plasticity: The effective medium A parameter and the Heckel 1/K parameter

An experimental evaluation of the accuracy to simulate granule bed compression using the discrete element method

Persson, Ann-Sofie; Frenning, Göran

Part of Powder Technology, p. 249-256, 2012.

Article in journal

DOI for An experimental evaluation of the accuracy to simulate granule bed compression using the discrete element method Download full text (pdf) of An experimental evaluation of the accuracy to simulate granule bed compression using the discrete element method

An experimental evaluation of an effective medium based compaction equation

Mahmoodi, Foad; Alderborn, Göran; Frenning, Göran

Part of European Journal of Pharmaceutical Sciences, p. 49-55, 2012.

Article in journal

DOI for An experimental evaluation of an effective medium based compaction equation Download full text (pdf) of An experimental evaluation of an effective medium based compaction equation

A model describing the internal structure of core/shell hydrogels

Gernandt, Jonas; Frenning, Göran; Richtering, Walter; Hansson, Per

Part of Soft Matter, p. 10327-10338, 2011.

Article in journal

DOI for A model describing the internal structure of core/shell hydrogels

Modelling drug release from inert matrix systems: From moving-boundary to continuous-field descriptions

Frenning, Göran

Part of International Journal of Pharmaceutics, p. 88-99, 2011.

Article, review/survey

DOI for Modelling drug release from inert matrix systems: From moving-boundary to continuous-field descriptions Download full text (pdf) of Modelling drug release from inert matrix systems: From moving-boundary to continuous-field descriptions

The Release of Catanionic Mixtures Embedded in Gels: An Approximate Analytical Analysis

Frenning, Göran; Gråsjö, Johan; Hansson, Per

Part of AIChE Journal, p. 1402-1408, 2011.

Article in journal

DOI for The Release of Catanionic Mixtures Embedded in Gels: An Approximate Analytical Analysis Download full text (pdf) of The Release of Catanionic Mixtures Embedded in Gels: An Approximate Analytical Analysis

Flowability of surface modified pharmaceutical granules: A comparative experimental and numerical study

Persson, Ann-Sofie; Alderborn, Göran; Frenning, Göran

Part of European Journal of Pharmaceutical Sciences, p. 199-209, 2011.

Article in journal

DOI for Flowability of surface modified pharmaceutical granules: A comparative experimental and numerical study Download full text (pdf) of Flowability of surface modified pharmaceutical granules: A comparative experimental and numerical study

Modeling structure-function relationships for diffusive drug transport in inert porous geopolymer matrices

Jämstorp, Erik; Strømme, Maria; Frenning, Göran

Part of Journal of Pharmaceutical Sciences, p. 4338-4348, 2011.

Article in journal

DOI for Modeling structure-function relationships for diffusive drug transport in inert porous geopolymer matrices Download full text (pdf) of Modeling structure-function relationships for diffusive drug transport in inert porous geopolymer matrices

Effect of spherical-agglomerate strength on the distribution of force during uniaxial compression

Mahmoodi, Foad; Alderborn, Göran; Frenning, Göran

Part of Powder Technology, p. 283-290, 2011.

Article in journal

DOI for Effect of spherical-agglomerate strength on the distribution of force during uniaxial compression Download full text (pdf) of Effect of spherical-agglomerate strength on the distribution of force during uniaxial compression

Compression mechanics of granule beds: A combined finite/discrete element study

Frenning, Göran

Part of Chemical Engineering Science, p. 2464-2471, 2010.

Article in journal

DOI for Compression mechanics of granule beds: A combined finite/discrete element study Download full text (pdf) of Compression mechanics of granule beds: A combined finite/discrete element study

Effect of lubrication on the distribution of force between spherical agglomerates during compression

Mahmoodi, Foad; Alderborn, Göran; Frenning, Göran

Part of Powder Technology, p. 69-74, 2010.

Article in journal

DOI for Effect of lubrication on the distribution of force between spherical agglomerates during compression Download full text (pdf) of Effect of lubrication on the distribution of force between spherical agglomerates during compression

Proton Absorption in As-Synthesized Mesoporous Silica Nanoparticles as a Structure-Function Relationship Probing Mechanism

Strømme, Maria; Atluri, Rambabu; Brohede, Ulrika; Frenning, Göran et al.

Part of Langmuir, p. 4306-4310, 2009.

Article in journal

DOI for Proton Absorption in As-Synthesized Mesoporous Silica Nanoparticles as a Structure-Function Relationship Probing Mechanism