Recent publications

Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Olsson, Frida; Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan et al.

Part of Biochemistry and Biophysics Reports, 2022.

DOI for Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells Download full text (pdf) of Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Part of Nature Communications, 2022.

DOI for A method for Boolean analysis of protein interactions at a molecular level Download full text (pdf) of A method for Boolean analysis of protein interactions at a molecular level

ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Rosén, Jacob; Norlin, Maria; Stattin, Karl; Lipcsey, Miklós et al.

Part of PLOS ONE, 2021.

DOI for ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study. Download full text (pdf) of ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

Zayny, Ahmad; Almokhtar, Mokhtar; Wikvall, Kjell; Ljunggren, Östen et al.

Part of Molecular and Cellular Endocrinology, 2019.

DOI for Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Emanuelsson, Ida; Almokhtar, Mokhtar; Wikvall, Kjell; Gröndbladh, Alfhild et al.

Part of Neurochemistry International, p. 46-55, 2018.

DOI for Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Emanuelsson, Ida; Wikvall, Kjell; Friman, Tomas; Norlin, Maria

Part of Neuroscience, 2018.

DOI for Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Norlin, Maria; Lundqvist, Johan; Ellfolk, Maria; Hellström Pigg, Maritta et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 59-63, 2017.

DOI for Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Almokhtar, Mokhtar; Wikvall, Kjell; Ubhayasekera, S. J. Kumari A.; Bergquist, Jonas et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 178-188, 2016.

DOI for Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Wegler, Christine; Wikvall, Kjell; Norlin, Maria

Part of Basic & Clinical Pharmacology & Toxicology, 2016.

DOI for Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Wicher, Grzegorz; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 21-27, 2015.

DOI for Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Emanuelsson, Ida; Norlin, Maria

Part of Neuroscience Letters, p. 44-48, 2012.

DOI for Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Lundqvist, Johan; Wikvall, Kjell; Norlin, Maria

Part of Biochimica et Biophysica Acta - General Subjects, p. 1553-1559, 2012.

DOI for Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 973-979, 2012.

DOI for Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 263-270, 2011.

DOI for 1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Norlin, Maria; Pettersson, Hanna; Tang, Wanjin; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 236-241, 2011.

DOI for Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

Svenningsen, Åsa Fex; Wicher, Grzegorz; Lundqvist, Johan; Pettersson, Hanna et al.

Part of Neurochemistry International, p. 620-624, 2011.

DOI for Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1056-1062, 2010.

DOI for 1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

Pettersson, Hanna; Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1090-1097, 2010.

DOI for Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1)

Norlin, Maria; Wikvall, Kjell

Part of Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010.

Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Ellfolk, Maria; Norlin, Maria; Gyllensten, Katarina; Wikvall, Kjell

Part of Molecular Pharmacology, p. 1392-1399, 2009.

DOI for Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

Pettersson, Hanna; Lundqvist, Johan; Oliw, Ernst; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1206-1215, 2009.

DOI for CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

CYP7B1 (cytochrome P450, family 7, subfamily B, polypeptide 1)

Norlin, Maria

Part of Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2009.

CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Pettersson, Hanna; Holmberg, Lisa; Axelson, Magnus; Norlin, Maria

Part of The FEBS Journal, p. 1778-1789, 2008.

DOI for CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Pettersson, Hanna; Norlin, Maria; Andersson, Ulla; Pikuleva, Irina et al.

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 383-390, 2008.

DOI for Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Tang, Wanjin; Pettersson, Hanna; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 63-73, 2008.

DOI for Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 718-723, 2008.

DOI for Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 13-20, 2007.

DOI for Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Hosseinpour, Fardin; Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 603-607, 2007.

DOI for Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Part of Drug Metab Dispos, p. 984-92, 2006.

Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Tang, Wanjin; Norlin, Maria

Part of Biochemical and Biophysical Research Communications - BBRC, p. 540-546, 2006.

DOI for Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Tang, Wanjin; Norlin, Maria

Part of Biochemical and Biophysical Research Communications - BBRC, p. 540-546, 2006.

DOI for Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues

Tang, Wanjin; Eggertsen, Gösta; Chiang, John Y.L.; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 42-51, 2006.

DOI for Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues

Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 568-572, 2006.

DOI for Isolation and properties of the CYP2D25 promoter: Transcriptional regulation by vitamin D3 metabolites

Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1.

Hansson, Magnus; Wikvall, Kjell; Babiker, Amir

Part of Biochim Biophys Acta, p. 44-51, 2005.

Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein

Norlin, Maria; Chiang, John Y. L.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 158-164, 2004.

DOI for Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein

Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1.

Araya, Zufan; Tang, Wanjin; Wikvall, Kjell

Part of Biochemical Journal, p. 529-534, 2003.

Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)

Lundell, Kerstin; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 86-96, 2003.

DOI for Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)

On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation

Norlin, Maria; von Bahr, Sara; Björkhem, Ingemar; Wikvall, Kjell

Part of Journal of Lipid Research, p. 1515-1522, 2003.

DOI for On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation

25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes:evidence for a role of both CYP2D25 and CYP27A1

Hosseinpour, Fardin; Ibranovic, Ines; Tang, Wanjin; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 877-883, 2003.

DOI for 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes:evidence for a role of both CYP2D25 and CYP27A1

Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1

Araya, Zufan; Hosseinpour, Fardin; Bodin, Karl; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 40-47, 2003.

DOI for Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1

Hormonal regulation of the human sterol 27-hydroxylase gene (CYP27A1)

Zufan, Araya; Tang, Wanjin; Wikvall, Kjell

Part of Biochemical Journal, p. 529-534, 2003.

DOI for Hormonal regulation of the human sterol 27-hydroxylase gene (CYP27A1)

Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver: no coordinate regulation of CYP7A1 and CYP27A1.

Bjorkhem, I; Araya, Zufan; Rudling, M; Angelin, B et al.

Part of Journal of Biological Chemistry, p. 26804-26807, 2002.

DOI for Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver: no coordinate regulation of CYP7A1 and CYP27A1.

Metabolism of 4 beta -hydroxycholesterol in humans

Bodin, Karl; Andersson, Ulla; Rystedt, Eva; Ellis, Eva et al.

Part of Journal of Biological Chemistry, p. 31534-31540, 2002.

DOI for Metabolism of 4 beta -hydroxycholesterol in humans

The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase)

Hosseinpour, Fardin; Hidestrand, Mats; Ingelman-Sundberg, Magnus; Wikvall, Kjell

Part of Biochem Biophys Res Commun, p. 1059-, 2001.

Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily

Lundell, Kerstin; Hansson, Ronnie; Wikvall, Kjell

Part of Journal of Biological Chemistry, p. 9606-9612, 2001.

DOI for Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7 alpha-hydroxylase (CYP7A)

Norlin, Maria; Toll, Anders; Bjorkhem, Ingemar; Wikvall, Kjell

Part of Journal of Lipid Research, p. 1629-1639, 2000.

Porcine microsomal vitamin D-3 25-hydroxylase (CYP2D25): Catalytic properties, tissue distribution, and comparison with human CYP2D6

Hosseinpour, Fardin; Wikvall, Kjell

Part of Journal of Biological Chemistry, p. 34650-34655, 2000.

DOI for Porcine microsomal vitamin D-3 25-hydroxylase (CYP2D25): Catalytic properties, tissue distribution, and comparison with human CYP2D6

Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A)

Norlin, Maria; Andersson, Ulla; Björkhem, Ingemar; Wikvall, Kjell

Part of Journal of Biological Chemistry, p. 34046-34053, 2000.

DOI for Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A)

Norlin, Maria

Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

2000.

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Lundell, Kerstin; Wikvall, Kjell

Part of Biochimica et Biophysica Acta