Recent publications

Purification of DNA oligonucleotides to improve hybridization chain reaction performance

Leino, Mattias; Söderberg, Ola

Part of New Biotechnology, p. 33-40, 2023.

DOI for Purification of DNA oligonucleotides to improve hybridization chain reaction performance Download full text (pdf) of Purification of DNA oligonucleotides to improve hybridization chain reaction performance

Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Olsson, Frida; Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan et al.

Part of Biochemistry and Biophysics Reports, 2022.

DOI for Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells Download full text (pdf) of Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

DOI for Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling Download full text (pdf) of Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Part of Nature Communications, 2022.

DOI for A method for Boolean analysis of protein interactions at a molecular level Download full text (pdf) of A method for Boolean analysis of protein interactions at a molecular level

Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Wåhlén, Erik; Olsson, Frida; Söderberg, Ola; Lennartsson, Johan et al.

Part of Cellular Signalling, 2022.

DOI for Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling Download full text (pdf) of Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

Frances-Soriano, Laura; Leino, Mattias; Dos Santos, Marcelina Cardoso; Kovacs, Daniel et al.

Part of Analytical Chemistry, p. 1842-1850, 2021.

DOI for In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Rosén, Jacob; Norlin, Maria; Stattin, Karl; Lipcsey, Miklós et al.

Part of PLOS ONE, 2021.

DOI for ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study. Download full text (pdf) of ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Part of Bioorganic chemistry (Print), 2020.

DOI for Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Part of Theranostics, p. 1122-1135, 2020.

DOI for Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression Download full text (pdf) of Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Part of Mutation research. Genetic toxicology and environmental mutagenesis, 2020.

DOI for Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

Zayny, Ahmad; Almokhtar, Mokhtar; Wikvall, Kjell; Ljunggren, Östen et al.

Part of Molecular and Cellular Endocrinology, 2019.

DOI for Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Wu, Chi-Chih; Klaesson, Axel; Buskas, Julia; Ranefall, Petter et al.

Part of Journal of Experimental Biology, 2019.

DOI for In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 469-474, 2019.

DOI for Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Leino, Mattias; Heldin, Johan; Rubin Sander, Marie; Kermpatsou, Despoina et al.

Part of Molecular Systems Design & Engineering, p. 1058-1065, 2019.

DOI for Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance Download full text (pdf) of Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Part of Experimental Cell Research, p. 69-79, 2019.

DOI for Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling Download full text (pdf) of Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of Journal of Cell Biology, p. 1701-1717, 2018.

DOI for PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Emanuelsson, Ida; Wikvall, Kjell; Friman, Tomas; Norlin, Maria

Part of Basic & Clinical Pharmacology & Toxicology, p. 130-136, 2018.

DOI for Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Emanuelsson, Ida; Almokhtar, Mokhtar; Wikvall, Kjell; Gröndbladh, Alfhild et al.

Part of Neurochemistry International, p. 46-55, 2018.

DOI for Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Klaesson, Axel; Grannas, Karin; Ebai, Tonge; Heldin, Johan et al.

Part of Scientific Reports, 2018.

DOI for Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes Download full text (pdf) of Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Norlin, Maria; Lundqvist, Johan; Ellfolk, Maria; Hellström Pigg, Maritta et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 59-63, 2017.

DOI for Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Vitamin D analogs tacalcitol and calcipotriol inhibit proliferation and migration of T98G human glioblastoma cells

Emanuelsson, Ida; Wikvall, Kjell; Friman, Tomas; Norlin, Maria

Part of Neuroscience, 2017.

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Löf, Liza; Arngården, Linda; Olsson-Strömberg, Ulla; Siart, Benjamin et al.

Part of Scientific Reports, p. 1-9, 2017.

DOI for Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia Download full text (pdf) of Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Insufficient antibody validation challenges oestrogen receptor beta research

Andersson, Sandra; Sundberg, Mårten; Pristovsek, Nusa; Ibrahim, Ahmed et al.

Part of Nature Communications, 2017.

DOI for Insufficient antibody validation challenges oestrogen receptor beta research Download full text (pdf) of Insufficient antibody validation challenges oestrogen receptor beta research

Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Almokhtar, Mokhtar; Wikvall, Kjell; Ubhayasekera, S. J. Kumari A.; Bergquist, Jonas et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 178-188, 2016.

DOI for Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Wegler, Christine; Wikvall, Kjell; Norlin, Maria

Part of Basic & Clinical Pharmacology & Toxicology, 2016.

DOI for Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Wicher, Grzegorz; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 21-27, 2015.

DOI for Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Emanuelsson, Ida; Norlin, Maria

Part of Neuroscience Letters, p. 44-48, 2012.

DOI for Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Lundqvist, Johan; Wikvall, Kjell; Norlin, Maria

Part of Biochimica et Biophysica Acta - General Subjects, p. 1553-1559, 2012.

DOI for Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 973-979, 2012.

DOI for Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 263-270, 2011.

DOI for 1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Norlin, Maria; Pettersson, Hanna; Tang, Wanjin; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 236-241, 2011.

DOI for Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

Svenningsen, Åsa Fex; Wicher, Grzegorz; Lundqvist, Johan; Pettersson, Hanna et al.

Part of Neurochemistry International, p. 620-624, 2011.

DOI for Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1056-1062, 2010.

DOI for 1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1)

Norlin, Maria; Wikvall, Kjell

Part of Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010.

Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

Pettersson, Hanna; Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1090-1097, 2010.

DOI for Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

CYP7B1 (cytochrome P450, family 7, subfamily B, polypeptide 1)

Norlin, Maria

Part of Atlas of genetics and cytogenetics in oncology and haematology, 2009.

Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Ellfolk, Maria; Norlin, Maria; Gyllensten, Katarina; Wikvall, Kjell

Part of Molecular Pharmacology, p. 1392-1399, 2009.

DOI for Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

Classen, Jean-Francois; Henrohn, Dan; Rorsman, Fredrik; Lennartsson, Johan et al.

Part of Arthritis and Rheumatism, p. 1137-1144, 2009.

DOI for Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

Pettersson, Hanna; Lundqvist, Johan; Oliw, Ernst; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1206-1215, 2009.

DOI for CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Pettersson, Hanna; Holmberg, Lisa; Axelson, Magnus; Norlin, Maria

Part of The FEBS Journal, p. 1778-1789, 2008.

DOI for CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Pettersson, Hanna; Norlin, Maria; Andersson, Ulla; Pikuleva, Irina et al.

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 383-390, 2008.

DOI for Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Tang, Wanjin; Pettersson, Hanna; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 63-73, 2008.

DOI for Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 718-723, 2008.

DOI for Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 13-20, 2007.

DOI for Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Hosseinpour, Fardin; Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 603-607, 2007.

DOI for Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Part of Drug Metab Dispos, p. 984-92, 2006.

Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Tang, Wanjin; Norlin, Maria

Part of Biochemical and Biophysical Research Communications - BBRC, p. 540-546, 2006.

DOI for Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Tang, Wanjin; Norlin, Maria

Part of Biochemical and Biophysical Research Communications - BBRC, p. 540-546, 2006.

DOI for Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues

Tang, Wanjin; Eggertsen, Gösta; Chiang, John Y.L.; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 42-51, 2006.

DOI for Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues

Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein

Norlin, Maria; Chiang, John Y. L.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 158-164, 2004.

DOI for Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein