Selected publications

Papadopoulos N, Lennartsson J and Heldin CH. PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element modifying factor 1.J Cell Biol. 2018 May 7;217(5):1701-1717

Heldin CH, Lennartsson J and Westermark B. Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis. J Intern Med, 2018 283(1):16-44

Papadopoulos N and Lennartsson J. The PDGF/PDGFR pathway as a drug target.Mol Aspects Med, 2017 Nov 15, pii: S0098-2997(17)30140-1

Rorsman C, Tsioumpekou M, Heldin CH and Lennartsson J. The ubiquitin ligases c-Cbl and Cbl-b negatively regulate PDGF-BB-induced chemotaxis by affecting PDGFRb internalization and signaling. J Biol Chem 2016 May 27;291(22):11608-18

Tsioumpekou MPapadopoulos NBurovic FHeldin CH and Lennartsson J. Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling. Cell Signal 2016 28:1422-1431

Sooman L, Ekman S,  Tsakonas G, Alafuzoff I, Popova S, Jaiswal A, Navani S, Edqvist    PE, Pontén F, Bergström S, Johansson M, Wu X, Blomquist E, Bergqvist M, Gullbo J and Lennartsson J. PTPN6 expression is epigenetically regulated and influences the response to therapy in high-grade gliomas. Tumor Biol, 2014 May;35(5):4479-88

Wu X, Sooman L, Wickström M, Fryknäs M, Dyrager C, Lennartsson J*, and Gullbo J*    Alternative cytotoxic effects of the postulated IGF-1R inhibitor picropodophyllin (PPP) in vitro. Mol Cancer Ther, 2013 Aug;12(8):1526-36 *equally contributing and corresponding senior authors

Sooman L, Ekman S, Andersson C, Göransson-Kultima H, Isaksson A, Johansson F, Bergqvist M, Blomquist E, Lennartsson J and Gullbo J. Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines. Cancer Chemother Pharmacol, 2013 Aug;72(2):329-40

Lennartsson J, Ma H, Wardega P, Pelka K, Engström U, Hellberg C and Heldin CH. The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced Stat3 phosphorylation, colony formation is soft agar and tumor growth in vivo.  J Biol Chem, 2013 May 31 288(22):15736-15744

Razmara M, Heldin CH and Lennartsson J. Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D. Cell Commun Signal, 2013 Jan 11;11(1):3