Recent publications

The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2023.

DOI for The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ Download full text (pdf) of The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

Wåhlén, Erik; Olsson, Frida; Raykova, Doroteya; Söderberg, Ola et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 195-201, 2023.

DOI for Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion Download full text (pdf) of Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Part of BMC Molecular and Cell Biology, 2023.

DOI for SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation Download full text (pdf) of SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Olsson, Frida; Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan et al.

Part of Biochemistry and Biophysics Reports, 2022.

DOI for Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells Download full text (pdf) of Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

DOI for Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling Download full text (pdf) of Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Wåhlén, Erik; Olsson, Frida; Söderberg, Ola; Lennartsson, Johan et al.

Part of Cellular Signalling, 2022.

DOI for Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling Download full text (pdf) of Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Part of Bioorganic chemistry (Print), 2020.

DOI for Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Part of Theranostics, p. 1122-1135, 2020.

DOI for Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression Download full text (pdf) of Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 469-474, 2019.

DOI for Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Part of Experimental Cell Research, p. 69-79, 2019.

DOI for Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling Download full text (pdf) of Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of Journal of Cell Biology, p. 1701-1717, 2018.

DOI for PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

Reyhani, Vahid; Tsioumpekou, Maria; van Wieringen, Tijs; Rask, Lars et al.

Part of Scientific Reports, 2017.

DOI for PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway Download full text (pdf) of PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Rorsman, Charlotte; Tsioumpekou, Maria; Heldin, Carl-Henrik; Lennartsson, Johan

Part of Journal of Biological Chemistry, p. 11608-11618, 2016.

DOI for The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling

Tsioumpekou, Maria; Papadopoulos, Natalia; Burovic, Fatima; Heldin, Carl-Henrik et al.

Part of Cellular Signalling, p. 1422-1431, 2016.

DOI for Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling

Mechanism of platelet-derived growth factor (PDGF) Erk5 MAP-kinase activation is cell type-dependent and can be independent of PDGF receptor kinase activity

Tsioumpekou, Maria; Papadopoulos, Natalia; Burovic, Fatima; Heldin, Carl-Henrik et al.

Part of International Journal of Molecular Medicine, p. S20-S20, 2015.

FGF2 as a potential prognostic biomarker for proneural glioma patients

Sooman, Linda; Freyhult, Eva; Jaiswal, Archita; Navani, Sanjay et al.

Part of Acta Oncologica, p. 385-394, 2015.

DOI for FGF2 as a potential prognostic biomarker for proneural glioma patients

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Vanlandewijck, Michael; Lebouvier, Thibaud; Mae, Maarja Andaloussi; Nahar, Khayrun et al.

Part of PLOS ONE, 2015.

DOI for Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification Download full text (pdf) of Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

Ma, Haisha; Wardega, Piotr; Mazaud, David; Klosowska-Wardega, Agnieszka et al.

Part of Cellular Signalling, p. 2209-2219, 2015.

DOI for Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells

Strömberg, Thomas; Feng, Xiaoying; Delforoush, Maryam; Berglund, Mattias et al.

Part of Medical Oncology, 2015.

DOI for Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells

NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar

Eger, Glenda; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of PLOS ONE, p. e109047-, 2014.

DOI for NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar Download full text (pdf) of NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar

PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas

Sooman, Linda; Ekman, Simon; Tsakonas, Georgios; Jaiswal, Archita et al.

Part of Tumor Biology, p. 4479-4488, 2014.

DOI for PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas

Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

Wu, Xuping; Sooman, Linda; Wickström, Malin; Fryknäs, Mårten et al.

Part of Molecular Cancer Therapeutics, p. 1526-1536, 2013.

DOI for Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

Lennartsson, Johan; Ma, Haisha; Wardega, Piotr; Pelka, Karin et al.

Part of Journal of Biological Chemistry, p. 15736-15744, 2013.

DOI for The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

RhoD Binds the Rab5 Effector Rabankyrin-5 and has a Role in Trafficking of the Platelet-derived Growth Factor Receptor

Nehru, Vishal; Voytyuk, Oleksandr; Lennartsson, Johan; Aspenström, Pontus

Part of Traffic, p. 1242-1254, 2013.

DOI for RhoD Binds the Rab5 Effector Rabankyrin-5 and has a Role in Trafficking of the Platelet-derived Growth Factor Receptor

Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival

Sooman, Linda; Lennartsson, Johan; Gullbo, Joachim; Bergqvist, Michael et al.

Part of Medical Oncology, p. 638-, 2013.

DOI for Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival

Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells

Wu, Xuping; Sooman, Linda; Lennartsson, Johan; Bergström, Stefan et al.

Part of International Journal of Oncology, p. 297-304, 2013.

DOI for Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells

Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

Sooman, Linda; Ekman, Simon; Andersson, Claes; Kultima, Hanna Göransson et al.

Part of Cancer Chemotherapy and Pharmacology, p. 329-340, 2013.

DOI for Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-gamma1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

Razmara, Masoud; Heldin, Carl-Henrik; Lennartsson, Johan

Part of Cell Communication and Signaling, 2013.

DOI for Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-gamma1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

Structural and functional properties of platelet-derived growth factor and stem cell factor receptors

Heldin, Carl-Henrik; Lennartsson, Johan

Part of Cold Spring Harbor Perspectives in Biology, p. UNSP a009100-, 2013.

DOI for Structural and functional properties of platelet-derived growth factor and stem cell factor receptors

SHP1 expression is epigenetically regulated and influences the sensitivity to chemotherapeutic agents in glioblastoma cells

Sooman, Linda; Ekman, S.; Bergqvist, Michael; Gullbo, Joachim et al.

Part of Neuro-Oncology, p. iii18-iii18, 2012.

DOI for SHP1 expression is epigenetically regulated and influences the sensitivity to chemotherapeutic agents in glioblastoma cells

MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis

Razmara, Masoud; Eger, Glenda; Rorsman, Charlotte; Heldin, Carl-Henrik et al.

Part of Cellular Signalling, p. 635-640, 2012.

DOI for MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis

The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Lennartsson, Johan; Nygren, Peter et al.

Part of International Journal of Oncology, p. 176-184, 2012.

DOI for The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines Download full text (pdf) of The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines

The HER2-binding Affibody Molecule (Z_HER2:342)₂ Increases Radiosensitivity in SKBR-3 cells

Ekerljung, Lina; Lennartsson, Johan; Gedda, Lars

Part of PLOS ONE, p. e49579-, 2012.

DOI for The HER2-binding Affibody Molecule (Z_HER2:342)₂ Increases Radiosensitivity in SKBR-3 cells Download full text (pdf) of The HER2-binding Affibody Molecule (Z_HER2:342)₂ Increases Radiosensitivity in SKBR-3 cells

Synergistic Effects of PI3K or P38 MAPK Inhibition in Combination With Vandetanib Treatment in Glioblastoma Cells

Sooman, Linda; Ekman, Simon; Andersson, Claes; Johansson, Fredrik et al.

Part of European Journal of Cancer, p. S244-S244, 2012.

DOI for Synergistic Effects of PI3K or P38 MAPK Inhibition in Combination With Vandetanib Treatment in Glioblastoma Cells

Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity

Wu, Xuping; Hedman, Håkan; Bergqvist, Michael; Bergström, Stefan et al.

Part of Acta Oncologica, p. 69-76, 2012.

DOI for Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Arora, Deepika; Köthe, Susanne; van den Eijnden, Monique; van Huijsduijnen, Rob Hooft et al.

Part of Cell Communication and Signaling, p. 19-, 2012.

DOI for Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression Download full text (pdf) of Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity

Zheng, Wei; Lennartsson, Johan; Hendriks, Wiljan; Heldin, Carl-Henrik et al.

Part of Cellular Signalling, p. 1050-1056, 2011.

DOI for The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity

Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

Jurek, Aleksandra; Heldin, Carl-Henrik; Lennartsson, Johan

Part of Cellular Signalling, p. 280-287, 2011.

DOI for Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

SOX10 expression in superficial spreading and nodular malignant melanomas

Agnarsdóttir, Margrét; Sooman, Linda; Bolander, Åsa; Strömberg, Sara et al.

Part of Melanoma research, p. 468-478, 2010.

DOI for SOX10 expression in superficial spreading and nodular malignant melanomas

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

Hou, Xu; Kumar, Anil; Lee, Chunsik; Wang, Bin et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 12216-12221, 2010.

DOI for PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

Tang, Zhongshu; Arjunan, Pachiappan; Lee, Chunsik; Li, Yang et al.

Part of Journal of Experimental Medicine, p. 867-880, 2010.

DOI for Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration

Wardega, Piotr; Heldin, Carl-Henrik; Lennartsson, Johan

Part of Cellular Signalling, p. 1363-1368, 2010.

DOI for Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration

Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis

Lennartsson, Johan; Burovic, Fatima; Witek, Barbara; Jurek, Aleksandra et al.

Part of Cellular Signalling, p. 955-960, 2010.

DOI for Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis

Effects of an EGFR-binding affibody molecule on intracellular signaling pathways

Nordberg, Erika; Ekerljung, Lina; Häggblad Sahlberg, Sara; Carlsson, Jörgen et al.

Part of International Journal of Oncology, p. 967-972, 2010.

DOI for Effects of an EGFR-binding affibody molecule on intracellular signaling pathways

Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation

Jurek, Aleksandra; Amagasaki, Kenichi; Gembarska, Agnieszka; Heldin, Carl-Henrik et al.

Part of Journal of Biological Chemistry, p. 4626-4634, 2009.

DOI for Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation

Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway

Lønne, Gry Kalstad; Masoumi, Katarzyna Chmielarska; Lennartsson, Johan; Larsson, Christer

Part of Journal of Biological Chemistry, p. 33456-33465, 2009.

DOI for Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

Classen, Jean-Francois; Henrohn, Dan; Rorsman, Fredrik; Lennartsson, Johan et al.

Part of Arthritis and Rheumatism, p. 1137-1144, 2009.

DOI for Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

Zhang, Fan; Tang, Zhongshu; Hou, Xu; Lennartsson, Johan et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 6152-6157, 2009.

DOI for VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

Wu, Xuping; Wanders, Alkwin; Wardega, Piotr; Tinge, B. et al.

Part of British Journal of Cancer, p. 334-343, 2009.

DOI for Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.

Li, Yang; Zhang, Fan; Nagai, Nobuo; Tang, Zhongshu et al.

Part of Journal of Clinical Investigation, p. 913-923, 2008.

DOI for VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.