Department of Pharmaceutical Biosciences

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Recent publications

Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats

Cattani, Daiane; Struyf, Nona; Steffensen, Vivien; Bergquist, Jonas et al.

Part of Toxicology, 2021.

DOI for Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats Download full text (pdf) of Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats

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The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region

Pierozan, Paula; Piras, Elena; Brittebo, Eva B; Karlsson, Oskar

Part of Archives of Toxicology, p. 2799-2808, 2020.

DOI for The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region Download full text (pdf) of The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region

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Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model

Islam, Azim Ullah Shamsul; Hellman, Björn; Nyberg, Fred; Amir, Naheed et al.

Part of Molecules, 2020.

DOI for Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model Download full text (pdf) of Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model

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Flash-comet assay

Bivehed, Erik; Hellman, Björn

Part of MethodsX, 2020.

DOI for Flash-comet assay Download full text (pdf) of Flash-comet assay

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Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data

Bivehed, Erik; Gustafsson, Anton; Berglund, Anders; Hellman, Björn

Part of Exposure and Health, p. 547-554, 2020.

DOI for Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data Download full text (pdf) of Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data

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Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Part of Mutation research. Genetic toxicology and environmental mutagenesis, 2020.

DOI for Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis
Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells

Kahaliw, Wubayehu; Hellman, Björn; Engidawork, Ephrem

Part of BMC Complementary and Alternative Medicine, 2018.

DOI for Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells Download full text (pdf) of Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells

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In vitro bioanalysis of drinking water from source to tap

Rosenmai, Anna Kjerstine; Lundqvist, Johan; le Godec, Theo; Ohisson, Asa et al.

Part of Water Research, p. 272-280, 2018.

DOI for In vitro bioanalysis of drinking water from source to tap
Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Kononenko, Olga; Bazov, Igor; Watanabe, Hiroyuki; Gerashchenko, Ganna et al.

Part of Biochimica et Biophysica Acta, p. 246-255, 2017.

DOI for Opioid precursor protein isoform is targeted to the cell nuclei in the human brain
Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Bivehed, Erik; Strömvall, Robert; Bergquist, Jonas; Bakalkin, Georgy et al.

Part of Peptides, p. 20-27, 2017.

DOI for Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry Download full text (pdf) of Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

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Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies

Sui, Ping; Watanabe, Hiroyuki; Artemenko, Konstantin; Sun, Wei et al.

Part of European journal of mass spectrometry, p. 105-115, 2017.

DOI for Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies
Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue

Klint, Helén; Lejonklou, Margareta H.; Karimullina, Elina; Rönn, Monika et al.

Part of Upsala Journal of Medical Sciences, p. 20-27, 2017.

DOI for Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue Download full text (pdf) of Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue

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Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

Fex Svenningsen, Åsa; Löring, Svenja; Sørensen, Anna Lahn; Huynh, Ha Uyen Buu et al.

Part of Cellular and Molecular Life Sciences (CMLS), p. 4561-4572, 2017.

DOI for Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 Download full text (pdf) of Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

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Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

Kononenko, Olga; Galatenko, Vladimir; Andersson, Malin; Bazov, Igor et al.

Part of The FASEB Journal, p. 1953-1963, 2017.

DOI for Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits
β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling

Engskog, Mikael K. R.; Ersson, Lisa; Haglöf, Jakob; Arvidsson, Torbjörn et al.

Part of Amino Acids, p. 905-919, 2017.

DOI for β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling Download full text (pdf) of β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling

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Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer

Al Shemaili, Jasem; Parekh, Khatija A.; Newman, Robert A.; Hellman, Björn et al.

Part of Marine Drugs, 2016.

DOI for Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer Download full text (pdf) of Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer

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Fungicide prochloraz induces oxidative stress and DNA damage in vitro

Lundqvist, J.; Hellman, Björn; Oskarsson, A.

Part of Food and Chemical Toxicology, p. 36-41, 2016.

DOI for Fungicide prochloraz induces oxidative stress and DNA damage in vitro
A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Mohotti, S.; Rajendran, S.; Muhammad, Taj; Strömstedt, Adam A. et al.

Part of Planta Medica, 2016.

DOI for A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents
Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Schweizer, Nadine; Viereckel, Thomas; Smith-Anttila, Casey J. A.; Nordenankar, Karin et al.

Part of eNeuro, 2016.

DOI for Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption
Quantitative mass spectrometry imaging of small-molecule neurotransmitters in rat brain tissue sections using nanospray desorption electrospray ionization

Bergman, Hilde-Marléne; Lundin, Erik; Andersson, Malin; Lanekoff, Ingela

Part of The Analyst, p. 3686-3695, 2016.

DOI for Quantitative mass spectrometry imaging of small-molecule neurotransmitters in rat brain tissue sections using nanospray desorption electrospray ionization
Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

Karlsson, Oskar; Berg, Anna-Lena; Hanrieder, Jörg; Arnerup, Gunnel et al.

Part of Archives of Toxicology, p. 423-436, 2015.

DOI for Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA Download full text (pdf) of Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

Open access
Correction: Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Andersson, Marie; Karlsson, Oskar; Bergström, Ulrika; Brittebo, Eva B. et al.

Part of PLOS ONE, 2015.

DOI for Correction: Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain

Karlsson, Oskar; Jiang, Liying; Ersson, Lisa; Malmstrom, Tim et al.

Part of Scientific Reports, 2015.

DOI for Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain Download full text (pdf) of Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain

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Protein association of the neurotoxin and non-protein amino acid BMAA (beta-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats

Karlsson, Oskar; Jiang, Liying; Andersson, Marie; Ilag, Leopold L. et al.

Part of Toxicology Letters, p. 1-5, 2014.

DOI for Protein association of the neurotoxin and non-protein amino acid BMAA (beta-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats
Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer

Al Shemaili, Jasem; Mensah-Brown, E.; Parekh, K.; Thomas, S. A. et al.

Part of European Journal of Cancer, p. 1391-1398, 2014.

DOI for Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer
Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA)

Karlsson, Oskar; Bergquist, Jonas; Andersson, Malin

Part of Molecular & Cellular Proteomics, p. 93-104, 2014.

DOI for Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) Download full text (pdf) of Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA)

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Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry

Hanrieder, Jorg; Karlsson, Oskar; Brittebo, Eva B.; Malmberg, Per et al.

Part of Surface and Interface Analysis, p. 375-378, 2014.

DOI for Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry
High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS

Hanrieder, Jörg; Gerber, Lorenz; Persson Sandelius, Asa; Brittebo, Eva B et al.

Part of ACS Chemical Neuroscience, p. 568-575, 2014.

DOI for High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS
Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis

Fransson, Moa; Piras, Elena; Wang, Hao; Burman, Joachim et al.

Part of Immunology, p. 431-441, 2014.

DOI for Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis
Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage

Åsgård, Rikard; Hellman, Björn

Part of Free radical research, p. 692-698, 2013.

DOI for Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage
Is the risk of narcolepsy also increased with non-adjuvanted flu vaccines?

Waldenlind, Lennart; Grundmark, Birgitta; Azarbayjani, Faranak; Borjesson, Andreas et al.

Part of BMJ. British Medical Journal, p. f2769-, 2013.

DOI for Is the risk of narcolepsy also increased with non-adjuvanted flu vaccines?
Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool

Åsgård, Rikard; Haghdoost, Siamak; Osterman Golkar, Siv; Hellman, Björn et al.

Part of Mutagenesis, p. 637-644, 2013.

DOI for Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool
MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis

Hanrieder, Jörg; Ekegren, Titti; Andersson, Malin; Bergquist, Jonas

Part of Journal of Neurochemistry, p. 695-707, 2013.

DOI for MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis
Analysis of neuropeptides by MALDI imaging mass spectrometry

Ljungdahl, Anna; Hanrieder, Jörg; Bergquist, Jonas; Andersson, Malin

Part of Methods in Molecular Biology, p. 121-136, 2013.

DOI for Analysis of neuropeptides by MALDI imaging mass spectrometry
Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats

Karlsson, Oskar; Kultima, Kim; Wadensten, Henrik; Nilsson, Anna et al.

Part of Journal of Proteome Research, p. 1678-1690, 2013.

DOI for Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats
The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats

Engskog, Mikael K R; Karlsson, Oskar; Haglöf, Jakob; Elmsjö, Albert et al.

Part of Amino Acids, p. 905-919, 2013.

DOI for The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats
Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Andersson, Marie; Karlsson, Oskar; Bergström, Ulrika; Brittebo, Eva B. et al.

Part of PLOS ONE, p. e78133-, 2013.

DOI for Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring Download full text (pdf) of Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Open access
An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides

Demma, Jemal; El-Seedi, Hesham; Engidawork, Ephrem; Aboye, Teshome Leta et al.

Part of Phytotherapy Research, p. 507-514, 2013.

DOI for An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides
Tamoxifen Modulates Cell Migration and Expression of Angiogenesis-Related Genes in Human Endometrial Endothelial Cells

Helmestam, Malin; Andersson, Helén; Stavreus-Evers, Anneli; Brittebo, Eva et al.

Part of American Journal of Pathology, p. 2527-2535, 2012.

DOI for Tamoxifen Modulates Cell Migration and Expression of Angiogenesis-Related Genes in Human Endometrial Endothelial Cells
Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action

Yeshak, Mariamawit Y; Göransson, Ulf; Burman, Robert; Hellman, Björn

Part of Mutation research. Genetic toxicology and environmental mutagenesis, p. 176-181, 2012.

DOI for Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action
Neurotoxin-induced fibril formation and protein changes in rodents

Brittebo, Eva; Karlsson, Oskar; Andersson, Malin; Berg, Anna-Lena et al.

Part of Toxicology Letters, p. S193-193, 2012.

DOI for Neurotoxin-induced fibril formation and protein changes in rodents
MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

Hanrieder, Jörg; Ljungdahl, Anna; Andersson, Malin

Part of Journal of Visualized Experiments, 2012.

DOI for MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease Download full text (pdf) of MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

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Proangiogenic Effects of Environmentally Relevant Levels of Bisphenol A in Human Primary Endothelial Cells

Andersson, Helén; Brittebo, Eva

Part of Archives of Toxicology, p. 465-474, 2012.

DOI for Proangiogenic Effects of Environmentally Relevant Levels of Bisphenol A in Human Primary Endothelial Cells
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Fransson, Moa; Piras, Elena; Burman, Joachim; Nilsson, Berith et al.

Part of Journal of Neuroinflammation, p. 112-, 2012.

DOI for CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery Download full text (pdf) of CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

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Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

Karlsson, Oskar; Berg, Anna-Lena; Lindström, Anna-Karin; Hanrieder, Jorg et al.

Part of Toxicological Sciences, p. 391-404, 2012.

DOI for Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus Download full text (pdf) of Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

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Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia

Lindgren, Hanna S.; Rylander, D.; Iderberg, H.; Andersson, Malin et al.

Part of Journal of Parkinson's Disease, p. 347-357, 2011.

DOI for Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period

Karlsson, Oskar; Roman, Erika; Berg, Anna-Lena; Brittebo, Eva

Part of Behavioural Brain Research, p. 310-320, 2011.

DOI for Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period
Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease

Ljungdahl, Anna; Hanrieder, Jörg; Fälth, Maria; Bergquist, Jonas et al.

Part of PLOS ONE, p. e25653-, 2011.

DOI for Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease Download full text (pdf) of Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease

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L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry

Hanrieder, Jörg; Ljungdahl, Anna; Fälth, Maria; Eriksson Mammo, Sofie et al.

Part of Molecular & Cellular Proteomics, p. M111.009308-, 2011.

DOI for L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry Download full text (pdf) of L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry

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MALDI mass spectrometry based molecular phenotyping of CNS glial cells for prediction in mammalian brain tissue

Hanrieder, Jörg; Wicher, Grzegorz; Bergquist, Jonas; Andersson, Malin et al.

Part of Analytical and Bioanalytical Chemistry, p. 135-147, 2011.

DOI for MALDI mass spectrometry based molecular phenotyping of CNS glial cells for prediction in mammalian brain tissue

Last modified: 2023-04-12