Recent publications

Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum

Zillich, Lea; Poisel, Eric; Frank, Josef; Foo, Jerome C. et al.

Part of Translational Psychiatry, 2022.

DOI for Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum Download full text (pdf) of Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Part of Bioorganic & Medicinal Chemistry, 2022.

DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Zelleroth, Sofia; Nylander, Erik; Kjellgren, Ellinor; Gröndbladh, Alfhild et al.

Part of Behavioural Brain Research, 2022.

DOI for Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat Download full text (pdf) of Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Stam, Frida; Lind, Sara Florén; Schroff, Anja; Zelleroth, Sofia et al.

Part of Current Issues in Molecular Biology, p. 5000-5012, 2022.

DOI for Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures Download full text (pdf) of Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Part of Bioorganic & Medicinal Chemistry, 2022.

DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders

Bakalkin, Georgy; Lukoyanov, Nikolay; Lavrov, Igor; Zhang, Mengliang

Part of Neural Regeneration Research, p. 2431-2433, 2022.

DOI for The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders Download full text (pdf) of The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2021.

DOI for The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Gröndbladh, Alfhild et al.

Part of Brain Research Bulletin, p. 126-134, 2021.

DOI for The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Lukoyanov, Nikolay; Watanabe, Hiroyuki; Carvalho, Liliana S.; Kononenko, Olga et al.

Part of eLIFE, 2021.

DOI for Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury Download full text (pdf) of Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring

Carvalho, Liliana S.; Brito, Helena M.; Lukoyanova, Elena A.; Maia, Gisela H. et al.

Part of European Journal of Neuroscience, p. 3621-3633, 2021.

DOI for Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring Download full text (pdf) of Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring

Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Bakalkin, Georgy; Nosova, Olga; Sarkisyan, Daniil; Hallberg, Mathias et al.

Part of Experimental Brain Research, p. 2221-2232, 2021.

DOI for Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats Download full text (pdf) of Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Abu Hamdeh, Sami; Ciuculete, Diana-Maria; Sarkisyan, Daniil; Bakalkin, Georgy et al.

Part of Journal of Neurotrauma, p. 1679-1688, 2021.

DOI for Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Watanabe, Hiroyuki; Kononenko, Olga; Sarkisyan, Daniil; Andersen, Marlene Storm et al.

Part of eNeuro, 2021.

DOI for Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury Download full text (pdf) of Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, Tianye; Chu, Congying; Liu, Yun; van Dongen, Jenny et al.

Part of Molecular Psychiatry, p. 3884-3895, 2021.

DOI for Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group Download full text (pdf) of Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Meng, Weida; Sjoholm, Louise K.; Kononenko, Olga; Tay, Nicole et al.

Part of Molecular Psychiatry, p. 4367-4382, 2021.

DOI for Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Bakalkin, Georgy; Kahle, Anika; Sarkisyan, Daniil; Watanabe, Hiroyuki et al.

Part of European Journal of Neuroscience, p. 5560-5573, 2021.

DOI for Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury Download full text (pdf) of Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Zelleroth, Sofia; Nylander, Erik; Örtenblad, Axel; Stam, Frida et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, 2021.

DOI for Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures Download full text (pdf) of Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

Grönbladh, Alfhild; Nylander, Erik; Zelleroth, Sofia; Hallberg, Mathias

Part of Methods in Molecular Biology, p. 171-180, 2021.

DOI for Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells

Nikulin, Sergey; Zakharova, Galina; Poloznikov, Andrey; Raigorodskaya, Maria et al.

Part of Frontiers in Genetics, 2021.

DOI for Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells Download full text (pdf) of Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Part of Bioorganic & Medicinal Chemistry, 2021.

DOI for N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Isaksson, Rebecka; Casselbrant, Anna; Elebring, Erik; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2020.

DOI for Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages Download full text (pdf) of Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias et al.

Part of Metabolomics, 2020.

DOI for Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver Download full text (pdf) of Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Nylander, Erik; Zelleroth, Sofia; Stam, Frida; Nyberg, Fred et al.

Part of Growth Hormone & IGF Research, p. 42-47, 2020.

DOI for Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Part of ChemistryOpen, p. 325-337, 2020.

DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Part of RSC Medicinal chemistry, p. 234-244, 2020.

DOI for Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Growing knowledge: How growth hormone improves learning

Nyberg, Fred; Hallberg, Mathias

Part of Acta Physiologica, 2020.

DOI for Growing knowledge: How growth hormone improves learning

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Vasile, Silvana; Hallberg, Anders; Sallander, Jessica; Hallberg, Mathias et al.

Part of Biomolecules, 2020.

DOI for Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists Download full text (pdf) of Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Mpakali, Anastasia; Saridakis, Emmanuel; Giastas, Petros; Maben, Zachary et al.

Part of ACS Medicinal Chemistry Letters, p. 1429-1434, 2020.

DOI for Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Seyer, Benjamin; Diwakarla, Shanti; Burns, Peta; Hallberg, Anders et al.

Part of Journal of Neurochemistry, p. 485-494, 2020.

DOI for Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry

Zhang, Mengliang; Watanabe, Hiroyuki; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Part of Brain Communications, 2020.

DOI for Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry Download full text (pdf) of Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe, Hiroyuki; Nosova, Olga; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Part of Brain Communications, 2020.

DOI for Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism Download full text (pdf) of Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Correlations between sex-related hormones, alcohol dependence and alcohol craving

Ho, Ada M-C; Geske, Jennifer R.; Bakalkin, Georgy; Winham, Stacey J. et al.

Part of Drug And Alcohol Dependence, p. 183-190, 2019.

DOI for Correlations between sex-related hormones, alcohol dependence and alcohol craving Download full text (pdf) of Correlations between sex-related hormones, alcohol dependence and alcohol craving

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Tay, Nicole; Macare, Christine; Liu, Yun; Ruggeri, Barbara et al.

Part of American Journal of Psychiatry, p. 146-155, 2019.

DOI for Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Kononenko, Olga; Watanabe, Hiroyuki; Stålhandske, Lada; Zarelius, Ann et al.

Part of Restorative Neurology and Neuroscience, p. 87-96, 2019.

DOI for Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord Download full text (pdf) of Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

Mueller, Christian P.; Chu, Congying; Qin, Liya; Liu, Chunyu et al.

Part of Cerebral Cortex, p. 1736-1751, 2019.

DOI for The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study Download full text (pdf) of The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Part of MedChemComm, p. 2146-2160, 2019.

DOI for High affinity rigidified AT(2) receptor ligands with indane scaffolds Download full text (pdf) of High affinity rigidified AT(2) receptor ligands with indane scaffolds

Differential suppression of the ipsi- and contralateral nociceptive reflexes in the neonatal rat spinal cord by agonists of μ-, δ- and κ-opioid receptors

Duarte, Joana; Fernandes, Elisabete C.; Kononenko, Olga; Sarkisyan, Daniil et al.

Part of Brain Research, p. 182-189, 2019.

DOI for Differential suppression of the ipsi- and contralateral nociceptive reflexes in the neonatal rat spinal cord by agonists of μ-, δ- and κ-opioid receptors

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

Zelleroth, Sofia; Nylander, Erik; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of Neuroscience, p. 172-183, 2019.

DOI for Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures Download full text (pdf) of Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

Part of ChemistryOpen, p. 114-125, 2019.

DOI for A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode Download full text (pdf) of A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Bazov, Igor; Sarkisyan, Daniil; Kononenko, Olga; Watanabe, Hiroyuki et al.

Part of Translational Psychiatry, 2018.

DOI for Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics Download full text (pdf) of Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Bazov, Igor; Sarkisyan, Daniil; Kononenko, Olga; Watanabe, Hiroyuki et al.

Part of Molecular Neurobiology, p. 7049-7061, 2018.

DOI for Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Download full text (pdf) of Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

Kononenko, Olga; Mityakina, Irina; Galatenko, Vladimir; Watanabe, Hiroyuki et al.

Part of Brain Research, p. 78-83, 2018.

DOI for Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

ASYMMETRIC HINDLIMB POSTURE AND WITHDRAW REFLEXES INDUCED BY UNILATERAL BRAIN INJURY ARE ENCODED IN SPINAL CORD

Zhang, Mengliang; Watanabe, Hiroyuki; Sarkisyan, Daniil; Thelin, Jonas et al.

Part of Journal of Neurotrauma, p. A208-A208, 2018.

Asymmetric Hindlimb Motor Response To Focal Traumatic Brain Injury Is Controlled By Side-Specific Opioid Mechanism

Watanabe, Hiroyuki; Zhang, Mengliang; Sarkisyan, Daniil; Kononenko, Olga et al.

Part of Journal of Neurotrauma, p. A79-A79, 2018.

Contralesional Hindlimb Motor Response Induced By Unilateral Brain Injury: Evidence For Extra Spinal Mechanism

Lukoyanov, Nikolay; Carvalho, Liliana; Watanabe, Hiroyuki; Zhang, Mengliang et al.

Part of Journal of Neurotrauma, p. A201-A201, 2018.

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Wannberg, Johan; Isaksson, Rebecka; Bremberg, Ulf; Backlund, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 519-522, 2018.

DOI for A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Reddy Vanga, Sudarsana; Sävmarker, Jonas; Ng, Leelee; Larhed, Mats et al.

Part of ACS Omega, p. 4509-4521, 2018.

DOI for Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides Download full text (pdf) of Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression

Ahmed, Aisha S.; Gedin, Per; Hugo, Anders; Bakalkin, Georgy et al.

Part of Journal of Immunology, p. 1918-1927, 2018.

DOI for Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression

Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

Brolin, Erika; Zelleroth, Sofia; Jonsson, Anna; Hallberg, Mathias et al.

Part of Pharmacology, Biochemistry and Behavior, p. 1-8, 2018.

DOI for Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018.

DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice