Recent publications

Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum

Zillich, Lea; Poisel, Eric; Frank, Josef; Foo, Jerome C. et al.

Part of Translational Psychiatry, 2022.

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The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders

Bakalkin, Georgy; Lukoyanov, Nikolay; Lavrov, Igor; Zhang, Mengliang

Part of Neural Regeneration Research, p. 2431-2433, 2022.

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DOI for The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders Download full text (pdf) of The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders

Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Lukoyanov, Nikolay; Watanabe, Hiroyuki; Carvalho, Liliana S.; Kononenko, Olga et al.

Part of eLIFE, 2021.

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DOI for Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury Download full text (pdf) of Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring

Carvalho, Liliana S.; Brito, Helena M.; Lukoyanova, Elena A.; Maia, Gisela H. et al.

Part of European Journal of Neuroscience, p. 3621-3633, 2021.

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DOI for Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring Download full text (pdf) of Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring

Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Bakalkin, Georgy; Nosova, Olga; Sarkisyan, Daniil; Hallberg, Mathias et al.

Part of Experimental Brain Research, p. 2221-2232, 2021.

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DOI for Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats Download full text (pdf) of Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Abu Hamdeh, Sami; Ciuculete, Diana-Maria; Sarkisyan, Daniil; Bakalkin, Georgy et al.

Part of Journal of Neurotrauma, p. 1679-1688, 2021.

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DOI for Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Watanabe, Hiroyuki; Kononenko, Olga; Sarkisyan, Daniil; Andersen, Marlene Storm et al.

Part of eNeuro, 2021.

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DOI for Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury Download full text (pdf) of Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, Tianye; Chu, Congying; Liu, Yun; van Dongen, Jenny et al.

Part of Molecular Psychiatry, p. 3884-3895, 2021.

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DOI for Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group Download full text (pdf) of Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Meng, Weida; Sjoholm, Louise K.; Kononenko, Olga; Tay, Nicole et al.

Part of Molecular Psychiatry, p. 4367-4382, 2021.

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DOI for Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Bakalkin, Georgy; Kahle, Anika; Sarkisyan, Daniil; Watanabe, Hiroyuki et al.

Part of European Journal of Neuroscience, p. 5560-5573, 2021.

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DOI for Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury Download full text (pdf) of Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells

Nikulin, Sergey; Zakharova, Galina; Poloznikov, Andrey; Raigorodskaya, Maria et al.

Part of Frontiers in Genetics, 2021.

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DOI for Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells Download full text (pdf) of Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells

Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry

Zhang, Mengliang; Watanabe, Hiroyuki; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Part of Brain Communications, 2020.

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DOI for Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry Download full text (pdf) of Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe, Hiroyuki; Nosova, Olga; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Part of Brain Communications, 2020.

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DOI for Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism Download full text (pdf) of Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Correlations between sex-related hormones, alcohol dependence and alcohol craving

Ho, Ada M-C; Geske, Jennifer R.; Bakalkin, Georgy; Winham, Stacey J. et al.

Part of Drug And Alcohol Dependence, p. 183-190, 2019.

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DOI for Correlations between sex-related hormones, alcohol dependence and alcohol craving Download full text (pdf) of Correlations between sex-related hormones, alcohol dependence and alcohol craving

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Tay, Nicole; Macare, Christine; Liu, Yun; Ruggeri, Barbara et al.

Part of American Journal of Psychiatry, p. 146-155, 2019.

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DOI for Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Kononenko, Olga; Watanabe, Hiroyuki; Stålhandske, Lada; Zarelius, Ann et al.

Part of Restorative Neurology and Neuroscience, p. 87-96, 2019.

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DOI for Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord Download full text (pdf) of Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

Mueller, Christian P.; Chu, Congying; Qin, Liya; Liu, Chunyu et al.

Part of Cerebral Cortex, p. 1736-1751, 2019.

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DOI for The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study Download full text (pdf) of The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

Differential suppression of the ipsi- and contralateral nociceptive reflexes in the neonatal rat spinal cord by agonists of μ-, δ- and κ-opioid receptors

Duarte, Joana; Fernandes, Elisabete C.; Kononenko, Olga; Sarkisyan, Daniil et al.

Part of Brain Research, p. 182-189, 2019.

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DOI for Differential suppression of the ipsi- and contralateral nociceptive reflexes in the neonatal rat spinal cord by agonists of μ-, δ- and κ-opioid receptors

Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Bazov, Igor; Sarkisyan, Daniil; Kononenko, Olga; Watanabe, Hiroyuki et al.

Part of Translational Psychiatry, 2018.

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DOI for Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics Download full text (pdf) of Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Bazov, Igor; Sarkisyan, Daniil; Kononenko, Olga; Watanabe, Hiroyuki et al.

Part of Molecular Neurobiology, p. 7049-7061, 2018.

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DOI for Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Download full text (pdf) of Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

Kononenko, Olga; Mityakina, Irina; Galatenko, Vladimir; Watanabe, Hiroyuki et al.

Part of Brain Research, p. 78-83, 2018.

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DOI for Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

ASYMMETRIC HINDLIMB POSTURE AND WITHDRAW REFLEXES INDUCED BY UNILATERAL BRAIN INJURY ARE ENCODED IN SPINAL CORD

Zhang, Mengliang; Watanabe, Hiroyuki; Sarkisyan, Daniil; Thelin, Jonas et al.

Part of Journal of Neurotrauma, p. A208-A208, 2018.

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Asymmetric Hindlimb Motor Response To Focal Traumatic Brain Injury Is Controlled By Side-Specific Opioid Mechanism

Watanabe, Hiroyuki; Zhang, Mengliang; Sarkisyan, Daniil; Kononenko, Olga et al.

Part of Journal of Neurotrauma, p. A79-A79, 2018.

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Contralesional Hindlimb Motor Response Induced By Unilateral Brain Injury: Evidence For Extra Spinal Mechanism

Lukoyanov, Nikolay; Carvalho, Liliana; Watanabe, Hiroyuki; Zhang, Mengliang et al.

Part of Journal of Neurotrauma, p. A201-A201, 2018.

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Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression

Ahmed, Aisha S.; Gedin, Per; Hugo, Anders; Bakalkin, Georgy et al.

Part of Journal of Immunology, p. 1918-1927, 2018.

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DOI for Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression

Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain

Bazov, Igor; Sarkisyan, Daniil; Kononenko, Olga; Watanabe, Hiroyuki et al.

Part of Cerebral Cortex, p. 3129-3142, 2018.

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DOI for Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

Ruggeri, Barbara; Macare, Christine; Stopponi, Serena; Jia, Tianye et al.

Part of Journal of Child Psychology and Psychiatry and Allied Disciplines, p. 50-658, 2018.

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DOI for Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Kononenko, Olga; Bazov, Igor; Watanabe, Hiroyuki; Gerashchenko, Ganna et al.

Part of Biochimica et Biophysica Acta, p. 246-255, 2017.

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DOI for Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Damaged reward areas in human alcoholics: neuronal proportion decline and astrocyte activation

Sarkisyan, Daniil; Bazov, Igor; Watanabe, Hiroyuki; Kononenko, Olga et al.

Part of Acta Neuropathologica, p. 485-487, 2017.

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DOI for Damaged reward areas in human alcoholics: neuronal proportion decline and astrocyte activation

Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.

Ahmed, Aisha Siddiqah; Ahmed, Mahmood; Li, Jian; Gu, Harvest F et al.

Part of International journal of rheumatic diseases, p. 25-32, 2017.

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DOI for Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.

Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Bivehed, Erik; Strömvall, Robert; Bergquist, Jonas; Bakalkin, Georgy et al.

Part of Peptides, p. 20-27, 2017.

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DOI for Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry Download full text (pdf) of Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies

Sui, Ping; Watanabe, Hiroyuki; Artemenko, Konstantin; Sun, Wei et al.

Part of European journal of mass spectrometry, p. 105-115, 2017.

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DOI for Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies

Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

Kononenko, Olga; Galatenko, Vladimir; Andersson, Malin; Bazov, Igor et al.

Part of The FASEB Journal, p. 1953-1963, 2017.

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DOI for Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

Lateralized response in endogenous pathogenic peptides dynorphins caused by traumatic brain injury: Relevance for human psychopathology

Yakovleva, Tatjana; Watanabe, Hiroyuki; Bakalkin, Georgy

Part of Brain Injury, p. 733-733, 2016.

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TBI induced spinal cord plasticity: The endogenous opioid system mediates trauma effects on motor reflexes

Bakalkin, Georgy; Watanabe, Hiroyuki; Kononenko, Olga; Stålhandske, Lada et al.

Part of Brain Injury, p. 712-712, 2016.

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Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23

Smeets, Cleo J. L. M.; Zmorzynska, Justyna; Melo, Manuel N.; Stargardt, Anita et al.

Part of Human Molecular Genetics, p. 2728-2737, 2016.

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DOI for Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23

The dynorphin/kappa-opioid receptor system: molecular and epigenetic adaptations in emotional circuitry of alcoholics

Bakalkin, Georgy; Yakovleva, Tatiana

Part of European Neuropsychopharmacology, p. S152-S152, 2016.

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KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, Gunter; Liu, Chunyu; O'Reilly, Paul; Gao, He et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 14372-14377, 2016.

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DOI for KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference

Sex-Specific Association of Prodynorphin Sequence Variation with Alcohol Dependence and Related Phenotypes

Winham, Stacey J.; Preuss, Ulrich W.; Geske, Jennifer R.; Zill, Peter et al.

Part of Biological Psychiatry, p. 408S-408S, 2015.

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Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction

Maximyuk, O.; Khmyz, V.; Lindskog, C-J; Vukojevic, V. et al.

Part of Cell Death and Disease, 2015.

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DOI for Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction Download full text (pdf) of Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis

Ruggeri, Barbara; Nymberg, Charlotte; Vuoksimaa, Eero; Lourdusamy, Anbarasu et al.

Part of American Journal of Psychiatry, p. 543-552, 2015.

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DOI for Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis

EPIGENOME IN THE BRAIN OF HUMAN ALCOHOLICS: GENETICALLY-REGULATED TRAJECTORIES OF DNA METHYLATION

Sarkisyan, Daniil; Bazov, Igor; Yakovleva, Tatiana; Bakalkin, Georgy

Part of Alcohol and Alcoholism, 2015.

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Gender Effects on Association Between PDYN Sequence Variation with Alcohol Dependence and Related Phenotypes

Karpyak, V. M.; Winham, S. J.; Biernacka, J. M.; Geske, J. et al.

Part of Alcohol and Alcoholism, 2015.

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THE ENDOGENOUS OPIOID SYSTEM: DYSREGULATION IN THE STRIATUM OF HUMAN ALCOHOLICS

Bazov, Igor; Sarkisyan, Daniil; Hussain, M. Z.; Watanabe, Hiroyuki et al.

Part of Alcohol and Alcoholism, 2015.

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OPIOIDERGIC MECHANISM IN ALCOHOLISM: TRANSLATIONAL STUDIES IN RODENTS AND HUMANS

Hirth, N.; Sommer, W. H.; Bakalkin, Georgy; Spanagel, R. et al.

Part of Alcohol and Alcoholism, 2015.

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Molecular mechanism for opioid dichotomy: bidirectional effect of mu-opioid receptors on P2X(3) receptor currents in rat sensory neurones

Chizhmakov, Igor; Kulyk, Vyacheslav; Khasabova, Iryna; Khasabov, Sergey et al.

Part of Purinergic Signalling Purinergic Signalling, p. 171-181, 2015.

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DOI for Molecular mechanism for opioid dichotomy: bidirectional effect of mu-opioid receptors on P2X(3) receptor currents in rat sensory neurones

Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain

Watanabe, Hiroyuki; Fitting, Sylvia; Hussain, Muhammad; Kononenko, Olga et al.

Part of Cerebral Cortex, p. 97-108, 2015.

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DOI for Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain Download full text (pdf) of Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23

Smeets, Cleo J. L. M.; Jezierska, Justyna; Watanabe, Hiroyuki; Duarri, Anna et al.

Part of Brain, p. 2537-2552, 2015.

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DOI for Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23

Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent

Winham, Stacey J.; Preuss, Ulrich W.; Geske, Jennifer R.; Zill, Peter et al.

Part of Scientific Reports, 2015.

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DOI for Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent Download full text (pdf) of Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Sarkisyan, Daniil; Hussain, Muhammad Zubair; Watanabe, Hiroyuki; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, 2015.

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DOI for Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics Download full text (pdf) of Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Proteomics of Neuropathic Pain: Proteins and Signaling Pathways Affected in a Rat Model

Sui, Ping; Watanabe, Hiroyuki; Ossipov, Michael; Bakalkin, Georgy et al.

Part of Journal of Proteome Research, p. 3957-3965, 2014.

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DOI for Proteomics of Neuropathic Pain: Proteins and Signaling Pathways Affected in a Rat Model

Brain Area-Specific Dysregulation Of The Dynorphin/Kappa-Opioid Receptor System In Human Alcoholics: Implications For Pathogenesis

Bakalkin, Georgy; Yakovleva, Tatiana; Bazov, Igor

Part of Alcoholism, p. 345A-345A, 2014.

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Pdyn Rs2281285 Variat Is Associated With The Length Of Sobriety In Alcohol Dependent Subjects

Karpyak, V. M.; Preuss, U. W.; Geske, J.; Winham, S. J. et al.

Part of Alcoholism, p. 148A-148A, 2014.

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Variations in PDYN Sequence are Associated with Post-treatment Relapse in Alcohol Dependent Subjects

Karpyak, Victor M.; Winham, Stacey J.; Biernacka, Joanna M.; Geske, Jennifer et al.

Part of Biological Psychiatry, p. 352S-352S, 2014.

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Opioid neuropeptides make pores in plasma membrane: possible mechanism of signal transduction

Krishtal, O.; Maximyuk, O.; Khmyz, V.; Lindskog, C. et al.

Part of Acta Physiologica, p. 12-12, 2014.

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The left-right neurohormonal regulation in the brain: Lateralized endogenous opioid system

Bakalkin, Georgy

Part of Acta Physiologica, p. 12-12, 2014.

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PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

Henriksson, Richard; Backman, Cristina M; Harvey, Brandon K; Kadyrova, Helena et al.

Part of Biochimica et Biophysica Acta, p. 1226-1232, 2014.

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DOI for PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Jin, Zhe; Bhandage, Amol K.; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, p. 288-, 2014.

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DOI for Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Jin, Zhe; Bhandage, Amol K; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, p. 11-, 2014.

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DOI for Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Bhandage, Amol K.; Jin, Zhe; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, 2014.

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DOI for GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

PDYN rs2281285 variant is associated with alcohol dependence in male but not female subjects

Karpyak, V. M.; Winham, S. J.; Preuss, U. W.; Zill, P. et al.

Part of European psychiatry, p. 1344-, 2013.

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DOI for PDYN rs2281285 variant is associated with alcohol dependence in male but not female subjects

Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment

Kuzmin, A.; Chefer, V.; Bazov, Igor; Meis, J. et al.

Part of Translational Psychiatry, p. e310-, 2013.

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DOI for Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment

Dimethyl-Labeling-Based Protein Quantification and Pathway Search: A Novel Method of Spinal Cord Analysis Applicable for Neurological Studies

Sui, Ping; Watanabe, Hiroyuki; Ossipov, Michael H.; Porreca, Frank et al.

Part of Journal of Proteome Research, p. 2245-2252, 2013.

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DOI for Dimethyl-Labeling-Based Protein Quantification and Pathway Search: A Novel Method of Spinal Cord Analysis Applicable for Neurological Studies

Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases.

Jezierska, Justyna; Stevanin, Giovanni; Watanabe, Hiroyuki; Fokkens, Michiel R et al.

Part of Journal of Neurology, p. 1807-1812, 2013.

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DOI for Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases.

Minor Allele Of Pdyn Rs2281285 Snp Is Positively Associated With Drinking To Overcome Mental Or Somatic Problems

Preuss, U. W.; Winham, S. J.; Biernacka, J. M.; Cunningham, J. M. et al.

Part of Alcoholism, p. 66A-66A, 2013.

Article in journal

The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction

Bazov, Igor; Kononenko, Olga; Watanabe, Hiroyuki; Kuntić, Vesna et al.

Part of Addiction Biology, p. 161-169, 2013.

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DOI for The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction

Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states

Karpyak, Victor M; Winham, Stacey J; Preuss, Ulrich W; Zill, Peter et al.

Part of International Journal of Neuropsychopharmacology, p. 975-985, 2013.

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DOI for Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states Download full text (pdf) of Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states

Dysregulation of the endogenous opioid system in the brain of human alcoholics

Bakalkin, Georgy; Bazov, Igor; Hussain, Muhammad Zubair; Sarkisyan, Daniil et al.

Part of European psychiatry, p. 2297-, 2013.

Article in journal

DOI for Dysregulation of the endogenous opioid system in the brain of human alcoholics

PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort

Preuss, Ulrich W.; Winham, Stacey J.; Biernacka, Joanna M.; Geske, Jennifer R. et al.

Part of PLOS ONE, p. e78688-, 2013.

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DOI for PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort Download full text (pdf) of PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort

Dysregulation of the dynorphin/kappa-opioid receptor system in cortical areas of human alcoholics: shift in epigenetic mechanisms

Bakalkin, Georgy; Yakovleva, Tatiana

Part of Alcoholism, p. 357A-357A, 2012.

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Variations in PDYN sequence are associated with negative craving in alcohol dependent subjects

Karpyak, V.; Winham, S.; Biernacka, J.; Cunningham, J. et al.

Part of European psychiatry, 2012.

Article in journal

DOI for Variations in PDYN sequence are associated with negative craving in alcohol dependent subjects

Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

Walker, Brendan M.; Valdez, Glenn R.; McLaughlin, Jay P.; Bakalkin, Georgy

Part of Alcohol, p. 359-370, 2012.

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DOI for Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

Lateralized Response of Dynorphin A Peptide Levels after Traumatic Brain Injury

Hussain, Zubair Muhammad; Fitting, Sylvia; Watanabe, Hiroyuki; Usynin, Ivan et al.

Part of Journal of Neurotrauma, p. 1785-1793, 2012.

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DOI for Lateralized Response of Dynorphin A Peptide Levels after Traumatic Brain Injury

Non-opioid nociceptive activity of human dynorphin mutants that cause neurodegenerative disorder spinocerebellar ataxia type 23

Watanabe, Hiroyuki; Mizoguchi, Hirokazu; Verbeek, Dineke S.; Kuzmin, Alexander et al.

Part of Peptides, p. 306-310, 2012.

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DOI for Non-opioid nociceptive activity of human dynorphin mutants that cause neurodegenerative disorder spinocerebellar ataxia type 23

Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis

Ahmed, Aisha S; Li, Jian; Erlandsson-Harris, Helena; Stark, André et al.

Part of Pain, p. 18-26, 2012.

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DOI for Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis

Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system

Sirohi, Sunil; Bakalkin, Georgy; Walker, Brendan M

Part of Frontiers in Molecular Neuroscience, p. 1-12, 2012.

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DOI for Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system

Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats

Kuzmin, Alexander; Liljequist, Sture; Meis, Jennifer; Chefer, Vladimir et al.

Part of Addiction Biology, p. 132-140, 2012.

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DOI for Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats

Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences

Taqi, Malik Mumtaz; Wärmländer, Sebastian K. T. S.; Yamskova, Olga; Madani, Fatemeh et al.

Part of PLOS ONE, p. e39605-, 2012.

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DOI for Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences Download full text (pdf) of Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences

Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Jin, Zhe; Bazov, Igor; Kononenko, Olga; Korpi, Esa R et al.

Part of Frontiers in Cellular Neuroscience, 2012.

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DOI for Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics Download full text (pdf) of Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking

Dong, Li; Bilbao, Ainhoa; Laucht, Manfred; Henriksson, Richard et al.

Part of American Journal of Psychiatry, p. 1090-1098, 2011.

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DOI for Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking

Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release

Chefer, Vladimir; Meis, Jennifer; Wang, Grace; Kuzmin, Alexander et al.

Part of Addiction Biology, p. 229-237, 2011.

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DOI for Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Schumann, Gunter; Coin, Lachlan J.; Lourdusamy, Anbarasu; Charoen, Pimphen et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7119-7124, 2011.

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DOI for Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Fluorescence imaging with single-molecule sensitivity and fluorescence correlation spectroscopy of cell-penetrating neuropeptides

Vukojević, Vladana; Gräslund, Astrid; Bakalkin, Georgy

Part of Neuropeptides, p. 147-170, 2011.

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DOI for Fluorescence imaging with single-molecule sensitivity and fluorescence correlation spectroscopy of cell-penetrating neuropeptides

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics

Taqi, Malik Mumtaz; Bazov, Igor; Watanabe, Hiroyuki; Sheedy, Donna et al.

Part of Addiction Biology, p. 499-509, 2011.

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DOI for Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics

Perturbations of model membranes induced by pathogenic dynorphin A mutants causing neurodegeneration in human brain

Madani, Fatemeh; Taqi, Malik Mumtaz; Warmlander, Sebastian K. T. S.; Verbeek, Dineke S. et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 111-114, 2011.

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DOI for Perturbations of model membranes induced by pathogenic dynorphin A mutants causing neurodegeneration in human brain

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain

Taqi, Malik Mumtaz; Bazov, Igor; Watanabe, Hiroyuki; Nyberg, Fred et al.

Part of Brain Research, p. 18-25, 2011.

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DOI for Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain

Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.

Bakalkin, Georgy; Watanabe, Hiroyuki; Jezierska, Justyna; Depoorter, Cloë et al.

Part of American Journal of Human Genetics, p. 593-603, 2010.

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DOI for Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.

Attenuation of Pain and Inflammation in Adjuvant-Induced Arthritis by the Proteasome Inhibitor MG132

Ahmed, Aisha S.; Li, Jian; Ahmed, Mahmood; Hua, Long et al.

Part of Arthritis and Rheumatism, p. 2160-2169, 2010.

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DOI for Attenuation of Pain and Inflammation in Adjuvant-Induced Arthritis by the Proteasome Inhibitor MG132

FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics

Watanabe, Hiroyuki; Henriksson, Richard; Ohnishi, Yoshinori N.; Ohnishi, Yoko H. et al.

Part of Addiction Biology, p. 294-297, 2009.

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DOI for FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics Download full text (pdf) of FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics

Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics

Kuzmin, Alexander; Bazov, Igor; Sheedy, Donna; Garrick, Therese et al.

Part of Brain Research, p. S80-85, 2009.

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DOI for Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics

Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine

Tan-No, Koichi; Shimoda, Masakazu; Watanabe, Kenya; Nakagawasai, Osamu et al.

Part of Neuroscience Letters, p. 365-368, 2009.

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DOI for Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine

Dysregulation of cell death machinery in the prefrontal cortex of human alcoholics

Johansson, Sofia; Ekström, Tomas J.; Marinova, Zoya; Ökvist, Anna et al.

Part of International Journal of Neuropsychopharmacology, p. 109-115, 2009.

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DOI for Dysregulation of cell death machinery in the prefrontal cortex of human alcoholics Download full text (pdf) of Dysregulation of cell death machinery in the prefrontal cortex of human alcoholics

Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics

Henriksson, Richard; Kuzmin, Alexander; Ökvist, Anna; Harper, Clive et al.

Part of Synapse, p. 829-33, 2008.

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DOI for Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics

Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription

El-Hage, Nazira; Bruce-Keller, Annadora J; Yakovleva, Tatiana; Bazov, Igor et al.

Part of PLOS ONE, p. e4093-, 2008.

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DOI for Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription

Calcium influx into phospholipid vesicles caused by dynorphin neuropeptides

Hugonin, Loïc; Vukojević, Vladana; Bakalkin, Georgy; Gräslund, Astrid

Part of Biochimica et Biophysica Acta - Biomembranes, p. 1267-1273, 2008.

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DOI for Calcium influx into phospholipid vesicles caused by dynorphin neuropeptides

Control of chronic pain by the ubiquitin-proteasome system in the spinal cord

Ossipov, Michael H.; Bazov, Igor; Gardell, Luis R.; Kowal, Justin et al.

Part of Journal of Neuroscience, p. 8226-37, 2007.

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Neuroadaptations in human chronic alcoholics: dysregulation of the NF-κB system

Ökvist, Anna; Johansson, Sofia; Kuzmin, Alexander; Bazov, Igor et al.

Part of PLoS ONE, p. e930-, 2007.

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Validation of endogenous controls for quantitative gene expression analysis: Application on brain cortices of human chronic alcoholics

Johansson, Sofia; Fuchs, Andrea; Ökvist, Anna; Karimi, Mohsen et al.

Part of Brain Research, p. 20-8, 2007.

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DOI for Validation of endogenous controls for quantitative gene expression analysis: Application on brain cortices of human chronic alcoholics

Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons

Adjan, V. V.; Hauser, K. F.; Bakalkin, Georgy; Yakovleva, T. et al.

Part of Neuroscience, p. 724-36, 2007.

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DOI for Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons

The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking

Kuzmin, Alexander; Kreek, Mary Jeanne; Bakalkin, Georgy; Liljequist, Sture

Part of Neuropsychopharmacology, p. 902-10, 2007.

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DOI for The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking