Recent publications

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Part of Bioorganic & Medicinal Chemistry, 2022.

DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Zelleroth, Sofia; Nylander, Erik; Kjellgren, Ellinor; Gröndbladh, Alfhild et al.

Part of Behavioural Brain Research, 2022.

DOI for Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat Download full text (pdf) of Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Stam, Frida; Lind, Sara Florén; Schroff, Anja; Zelleroth, Sofia et al.

Part of Current Issues in Molecular Biology, p. 5000-5012, 2022.

DOI for Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures Download full text (pdf) of Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Part of Bioorganic & Medicinal Chemistry, 2022.

DOI for Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds Download full text (pdf) of Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2021.

DOI for The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Gröndbladh, Alfhild et al.

Part of Brain Research Bulletin, p. 126-134, 2021.

DOI for The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Bakalkin, Georgy; Nosova, Olga; Sarkisyan, Daniil; Hallberg, Mathias et al.

Part of Experimental Brain Research, p. 2221-2232, 2021.

DOI for Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats Download full text (pdf) of Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Watanabe, Hiroyuki; Kononenko, Olga; Sarkisyan, Daniil; Andersen, Marlene Storm et al.

Part of eNeuro, 2021.

DOI for Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury Download full text (pdf) of Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Bakalkin, Georgy; Kahle, Anika; Sarkisyan, Daniil; Watanabe, Hiroyuki et al.

Part of European Journal of Neuroscience, p. 5560-5573, 2021.

DOI for Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury Download full text (pdf) of Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Zelleroth, Sofia; Nylander, Erik; Örtenblad, Axel; Stam, Frida et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, 2021.

DOI for Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures Download full text (pdf) of Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

Grönbladh, Alfhild; Nylander, Erik; Zelleroth, Sofia; Hallberg, Mathias

Part of Methods in Molecular Biology, p. 171-180, 2021.

DOI for Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Part of Bioorganic & Medicinal Chemistry, 2021.

DOI for N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Isaksson, Rebecka; Casselbrant, Anna; Elebring, Erik; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2020.

DOI for Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages Download full text (pdf) of Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias et al.

Part of Metabolomics, 2020.

DOI for Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver Download full text (pdf) of Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Nylander, Erik; Zelleroth, Sofia; Stam, Frida; Nyberg, Fred et al.

Part of Growth Hormone & IGF Research, p. 42-47, 2020.

DOI for Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Part of ChemistryOpen, p. 325-337, 2020.

DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Part of RSC Medicinal chemistry, p. 234-244, 2020.

DOI for Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Growing knowledge: How growth hormone improves learning

Nyberg, Fred; Hallberg, Mathias

Part of Acta Physiologica, 2020.

DOI for Growing knowledge: How growth hormone improves learning

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Vasile, Silvana; Hallberg, Anders; Sallander, Jessica; Hallberg, Mathias et al.

Part of Biomolecules, 2020.

DOI for Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists Download full text (pdf) of Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Mpakali, Anastasia; Saridakis, Emmanuel; Giastas, Petros; Maben, Zachary et al.

Part of ACS Medicinal Chemistry Letters, p. 1429-1434, 2020.

DOI for Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Seyer, Benjamin; Diwakarla, Shanti; Burns, Peta; Hallberg, Anders et al.

Part of Journal of Neurochemistry, p. 485-494, 2020.

DOI for Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe, Hiroyuki; Nosova, Olga; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Part of Brain Communications, 2020.

DOI for Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism Download full text (pdf) of Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Part of MedChemComm, p. 2146-2160, 2019.

DOI for High affinity rigidified AT(2) receptor ligands with indane scaffolds Download full text (pdf) of High affinity rigidified AT(2) receptor ligands with indane scaffolds

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

Zelleroth, Sofia; Nylander, Erik; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of Neuroscience, p. 172-183, 2019.

DOI for Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures Download full text (pdf) of Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

Part of ChemistryOpen, p. 114-125, 2019.

DOI for A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode Download full text (pdf) of A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Wannberg, Johan; Isaksson, Rebecka; Bremberg, Ulf; Backlund, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 519-522, 2018.

DOI for A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Reddy Vanga, Sudarsana; Sävmarker, Jonas; Ng, Leelee; Larhed, Mats et al.

Part of ACS Omega, p. 4509-4521, 2018.

DOI for Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides Download full text (pdf) of Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

Brolin, Erika; Zelleroth, Sofia; Jonsson, Anna; Hallberg, Mathias et al.

Part of Pharmacology, Biochemistry and Behavior, p. 1-8, 2018.

DOI for Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018.

DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of International Journal of Molecular Sciences, p. 1-16, 2018.

DOI for The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro Download full text (pdf) of The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 533-540, 2017.

DOI for Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 345-351, 2017.

DOI for Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Brolin, Erika; Johansson, Jenny; Zelleroth, Sofia; Diwakarla, Shanti et al.

Part of Neuroscience Letters, p. 15-20, 2017.

DOI for The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

Kalliomäki, Maija-Liisa; Sandblom, Gabriel; Hallberg, Mathias; Grönbladh, Alfhild et al.

Part of Scandinavian Journal of Pain, p. 1-6, 2016.

DOI for Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

Effects of growth hormone on brain function: new routes for the delivery of the hormone into the brain

Lai, Zhennan; Grönbladh, Alfhild; Hallberg, Mathias; Nyberg, Fred

Part of Amino Acids, p. 633-634, 2016.

Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Reddy Vanga, Sudarsana et al.

Part of Molecular Pharmacology, p. 413-424, 2016.

DOI for Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Nylander, Erik; Gröndbladh, Alfhild; Zelleroth, Sofia; Diwakarla, Shanti et al.

Part of Neuroscience, p. 538-547, 2016.

DOI for Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Engen, Karin; Rosenström, Ulrika; Axelsson, Hanna; Konda, Vivek et al.

Part of Assay and drug development technologies, p. 180-193, 2016.

DOI for Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016.

DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

[(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Grönbladh, Alfhild; Hallberg, Mathias

Part of Methods in Molecular Biology, p. 169-176, 2015.

DOI for [(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Part of ACS Medicinal Chemistry Letters, p. 178-182, 2015.

DOI for Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Jonsson, Anna; Fransson, Rebecca; Haramaki, Yutaka; Skogh, Anna et al.

Part of Neuroscience, p. 112-119, 2015.

DOI for Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Part of ChemistryOpen, p. 256-263, 2014.

DOI for Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Saralasin and Sarile Are AT2 Receptor Agonists

Guimond, Marie-Odile; Hallberg, Mathias; Gallo-Payet, Nicole; Wallinder, Charlotta

Part of ACS Medicinal Chemistry Letters, p. 1129-1132, 2014.

DOI for Saralasin and Sarile Are AT2 Receptor Agonists

Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

Johansson, Jenny; Grönbladh, Alfhild; Hallberg, Mathias

Part of Behavioural Brain Research, p. 164-174, 2014.

DOI for Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.

DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Grönbladh, Alfhild; Johansson, Jenny; Nyberg, Fred; Hallberg, Mathias

Part of Growth Hormone & IGF Research, p. 60-66, 2014.

DOI for Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Growth hormone reverses streptozotocin-induced cognitive impairments in male mice

Enhamre-Brolin, Erika; Carlsson, Anna; Hallberg, Mathias; Nyberg, Fred

Part of Behavioural Brain Research, p. 273-278, 2013.

DOI for Growth hormone reverses streptozotocin-induced cognitive impairments in male mice

Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

Johansson, Jenny; Grönbladh, Alfhild; Nyberg, Fred; Hallberg, Mathias

Part of Brain Research Bulletin, p. 100-106, 2013.

DOI for Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.

DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability