Equipment

Mass spectrometry instruments

•    SolariX 7T-2ω Fourier-Transform Ion Cyclotron Resonance (FTICR), Bruker Daltonics
The two solariX MALDI instruments allow for the mapping of the distribution of drugs and metabolites, neurotransmitters, neuropeptides and lipids. The FTICR instruments offer ultrahigh mass resolving power that maximizes the number of analytes detected. They require tissue sections to be placed on conductive glass slides.

•    MALDI-TOF-TOF ultrafleXtreme, Bruker Daltonics
The ultrafleXtreme instruments can be used for a broad variety of MALDI-MSI applications and can analyse samples at near cellular lateral resolution (10 µm). Requires tissue sections to be placed on conductive glass slides.

•    MALDI/DESI Q-Tof Synapt G2Si, Waters Corp.
The MALDI SYNAPT G2-Si is suited for analysis of tissue sections placed on regular microscope glass slides (non-conductive). Lateral resolution of 20 µm. 

•    DESI Xevo TQ-XS Triple Quadrupole Mass Spectrometry, Waters Corp. 
Analysis with the DESI Xevo TQ-XS instrument allows targeted imaging of small molecules on regular microscope glass slides (non-conductive) at a lateral resolution of 20 µm.

Matrix application and tissue cutting instruments

•TM-Sprayer, HTX-Technologies for MALDI matrix application

  
•MALDI matrix sublimation system
 

•CHIP-1000 Chemical Printer, Shimadzu Corp. for application of standard curves

 
•BioSpot Benchtop workstation, BT 600, BioFluidix for application of standard curves

•Cryostats, Leica CM1900 and CM1950, Leica Microsystems