Institutionen för farmaceutisk biovetenskap

Institutionen för farmaceutisk ... Forskning Läkemedelssäkerhet & Toxikologi Publikationer

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Senaste publikationer

Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats

Cattani, Daiane; Struyf, Nona; Steffensen, Vivien; Bergquist, Jonas et al.

Ingår i Toxicology, 2021.

DOI för Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats Ladda ner fulltext (pdf) av Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats

Open access
The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region

Pierozan, Paula; Piras, Elena; Brittebo, Eva B; Karlsson, Oskar

Ingår i Archives of Toxicology, s. 2799-2808, 2020.

DOI för The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region Ladda ner fulltext (pdf) av The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region

Open access
Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model

Islam, Azim Ullah Shamsul; Hellman, Björn; Nyberg, Fred; Amir, Naheed et al.

Ingår i Molecules, 2020.

DOI för Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model Ladda ner fulltext (pdf) av Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model

Open access
Flash-comet assay

Bivehed, Erik; Hellman, Björn

Ingår i MethodsX, 2020.

DOI för Flash-comet assay Ladda ner fulltext (pdf) av Flash-comet assay

Open access
Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data

Bivehed, Erik; Gustafsson, Anton; Berglund, Anders; Hellman, Björn

Ingår i Exposure and Health, s. 547-554, 2020.

DOI för Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data Ladda ner fulltext (pdf) av Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data

Open access
Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2020.

DOI för Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis
Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells

Kahaliw, Wubayehu; Hellman, Björn; Engidawork, Ephrem

Ingår i BMC Complementary and Alternative Medicine, 2018.

DOI för Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells Ladda ner fulltext (pdf) av Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells

Open access
In vitro bioanalysis of drinking water from source to tap

Rosenmai, Anna Kjerstine; Lundqvist, Johan; le Godec, Theo; Ohisson, Asa et al.

Ingår i Water Research, s. 272-280, 2018.

DOI för In vitro bioanalysis of drinking water from source to tap
Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Kononenko, Olga; Bazov, Igor; Watanabe, Hiroyuki; Gerashchenko, Ganna et al.

Ingår i Biochimica et Biophysica Acta, s. 246-255, 2017.

DOI för Opioid precursor protein isoform is targeted to the cell nuclei in the human brain
Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Bivehed, Erik; Strömvall, Robert; Bergquist, Jonas; Bakalkin, Georgy et al.

Ingår i Peptides, s. 20-27, 2017.

DOI för Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry Ladda ner fulltext (pdf) av Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Open access
Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies

Sui, Ping; Watanabe, Hiroyuki; Artemenko, Konstantin; Sun, Wei et al.

Ingår i European journal of mass spectrometry, s. 105-115, 2017.

DOI för Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies
Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue

Klint, Helén; Lejonklou, Margareta H.; Karimullina, Elina; Rönn, Monika et al.

Ingår i Upsala Journal of Medical Sciences, s. 20-27, 2017.

DOI för Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue Ladda ner fulltext (pdf) av Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue

Open access
Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

Fex Svenningsen, Åsa; Löring, Svenja; Sørensen, Anna Lahn; Huynh, Ha Uyen Buu et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 4561-4572, 2017.

DOI för Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1 Ladda ner fulltext (pdf) av Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

Open access
Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

Kononenko, Olga; Galatenko, Vladimir; Andersson, Malin; Bazov, Igor et al.

Ingår i The FASEB Journal, s. 1953-1963, 2017.

DOI för Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits
β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling

Engskog, Mikael K. R.; Ersson, Lisa; Haglöf, Jakob; Arvidsson, Torbjörn et al.

Ingår i Amino Acids, s. 905-919, 2017.

DOI för β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling Ladda ner fulltext (pdf) av β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling

Open access
Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer

Al Shemaili, Jasem; Parekh, Khatija A.; Newman, Robert A.; Hellman, Björn et al.

Ingår i Marine Drugs, 2016.

DOI för Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer Ladda ner fulltext (pdf) av Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer

Open access
Fungicide prochloraz induces oxidative stress and DNA damage in vitro

Lundqvist, J.; Hellman, Björn; Oskarsson, A.

Ingår i Food and Chemical Toxicology, s. 36-41, 2016.

DOI för Fungicide prochloraz induces oxidative stress and DNA damage in vitro
A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Mohotti, S.; Rajendran, S.; Muhammad, Taj; Strömstedt, Adam A. et al.

Ingår i Planta Medica, 2016.

DOI för A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents
Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Schweizer, Nadine; Viereckel, Thomas; Smith-Anttila, Casey J. A.; Nordenankar, Karin et al.

Ingår i eNeuro, 2016.

DOI för Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption
Quantitative mass spectrometry imaging of small-molecule neurotransmitters in rat brain tissue sections using nanospray desorption electrospray ionization

Bergman, Hilde-Marléne; Lundin, Erik; Andersson, Malin; Lanekoff, Ingela

Ingår i The Analyst, s. 3686-3695, 2016.

DOI för Quantitative mass spectrometry imaging of small-molecule neurotransmitters in rat brain tissue sections using nanospray desorption electrospray ionization
Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

Karlsson, Oskar; Berg, Anna-Lena; Hanrieder, Jörg; Arnerup, Gunnel et al.

Ingår i Archives of Toxicology, s. 423-436, 2015.

DOI för Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA Ladda ner fulltext (pdf) av Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

Open access
Correction: Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Andersson, Marie; Karlsson, Oskar; Bergström, Ulrika; Brittebo, Eva B. et al.

Ingår i PLOS ONE, 2015.

DOI för Correction: Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain

Karlsson, Oskar; Jiang, Liying; Ersson, Lisa; Malmstrom, Tim et al.

Ingår i Scientific Reports, 2015.

DOI för Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain Ladda ner fulltext (pdf) av Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain

Open access
Protein association of the neurotoxin and non-protein amino acid BMAA (beta-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats

Karlsson, Oskar; Jiang, Liying; Andersson, Marie; Ilag, Leopold L. et al.

Ingår i Toxicology Letters, s. 1-5, 2014.

DOI för Protein association of the neurotoxin and non-protein amino acid BMAA (beta-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats
Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer

Al Shemaili, Jasem; Mensah-Brown, E.; Parekh, K.; Thomas, S. A. et al.

Ingår i European Journal of Cancer, s. 1391-1398, 2014.

DOI för Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer
Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA)

Karlsson, Oskar; Bergquist, Jonas; Andersson, Malin

Ingår i Molecular & Cellular Proteomics, s. 93-104, 2014.

DOI för Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) Ladda ner fulltext (pdf) av Quality measures of imaging mass spectrometry aids in revealing long-term striatal protein changes induced by neonatal exposure to the cyanobacterial toxin β-N-methylamino-L-alanine (BMAA)

Open access
Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry

Hanrieder, Jorg; Karlsson, Oskar; Brittebo, Eva B.; Malmberg, Per et al.

Ingår i Surface and Interface Analysis, s. 375-378, 2014.

DOI för Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry
High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS

Hanrieder, Jörg; Gerber, Lorenz; Persson Sandelius, Asa; Brittebo, Eva B et al.

Ingår i ACS Chemical Neuroscience, s. 568-575, 2014.

DOI för High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS
Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis

Fransson, Moa; Piras, Elena; Wang, Hao; Burman, Joachim et al.

Ingår i Immunology, s. 431-441, 2014.

DOI för Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis
Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage

Åsgård, Rikard; Hellman, Björn

Ingår i Free radical research, s. 692-698, 2013.

DOI för Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage
Is the risk of narcolepsy also increased with non-adjuvanted flu vaccines?

Waldenlind, Lennart; Grundmark, Birgitta; Azarbayjani, Faranak; Borjesson, Andreas et al.

Ingår i BMJ. British Medical Journal, s. f2769-, 2013.

DOI för Is the risk of narcolepsy also increased with non-adjuvanted flu vaccines?
Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool

Åsgård, Rikard; Haghdoost, Siamak; Osterman Golkar, Siv; Hellman, Björn et al.

Ingår i Mutagenesis, s. 637-644, 2013.

DOI för Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool
MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis

Hanrieder, Jörg; Ekegren, Titti; Andersson, Malin; Bergquist, Jonas

Ingår i Journal of Neurochemistry, s. 695-707, 2013.

DOI för MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis
Analysis of neuropeptides by MALDI imaging mass spectrometry

Ljungdahl, Anna; Hanrieder, Jörg; Bergquist, Jonas; Andersson, Malin

Ingår i Methods in Molecular Biology, s. 121-136, 2013.

DOI för Analysis of neuropeptides by MALDI imaging mass spectrometry
Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats

Karlsson, Oskar; Kultima, Kim; Wadensten, Henrik; Nilsson, Anna et al.

Ingår i Journal of Proteome Research, s. 1678-1690, 2013.

DOI för Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats
The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats

Engskog, Mikael K R; Karlsson, Oskar; Haglöf, Jakob; Elmsjö, Albert et al.

Ingår i Amino Acids, s. 905-919, 2013.

DOI för The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats
Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Andersson, Marie; Karlsson, Oskar; Bergström, Ulrika; Brittebo, Eva B. et al.

Ingår i PLOS ONE, s. e78133-, 2013.

DOI för Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring Ladda ner fulltext (pdf) av Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

Open access
An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides

Demma, Jemal; El-Seedi, Hesham; Engidawork, Ephrem; Aboye, Teshome Leta et al.

Ingår i Phytotherapy Research, s. 507-514, 2013.

DOI för An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides
Tamoxifen Modulates Cell Migration and Expression of Angiogenesis-Related Genes in Human Endometrial Endothelial Cells

Helmestam, Malin; Andersson, Helén; Stavreus-Evers, Anneli; Brittebo, Eva et al.

Ingår i American Journal of Pathology, s. 2527-2535, 2012.

DOI för Tamoxifen Modulates Cell Migration and Expression of Angiogenesis-Related Genes in Human Endometrial Endothelial Cells
Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action

Yeshak, Mariamawit Y; Göransson, Ulf; Burman, Robert; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, s. 176-181, 2012.

DOI för Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action
Neurotoxin-induced fibril formation and protein changes in rodents

Brittebo, Eva; Karlsson, Oskar; Andersson, Malin; Berg, Anna-Lena et al.

Ingår i Toxicology Letters, s. S193-193, 2012.

DOI för Neurotoxin-induced fibril formation and protein changes in rodents
MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

Hanrieder, Jörg; Ljungdahl, Anna; Andersson, Malin

Ingår i Journal of Visualized Experiments, 2012.

DOI för MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease Ladda ner fulltext (pdf) av MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

Open access
Proangiogenic Effects of Environmentally Relevant Levels of Bisphenol A in Human Primary Endothelial Cells

Andersson, Helén; Brittebo, Eva

Ingår i Archives of Toxicology, s. 465-474, 2012.

DOI för Proangiogenic Effects of Environmentally Relevant Levels of Bisphenol A in Human Primary Endothelial Cells
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Fransson, Moa; Piras, Elena; Burman, Joachim; Nilsson, Berith et al.

Ingår i Journal of Neuroinflammation, s. 112-, 2012.

DOI för CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery Ladda ner fulltext (pdf) av CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Open access
Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

Karlsson, Oskar; Berg, Anna-Lena; Lindström, Anna-Karin; Hanrieder, Jorg et al.

Ingår i Toxicological Sciences, s. 391-404, 2012.

DOI för Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus Ladda ner fulltext (pdf) av Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

Open access
Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia

Lindgren, Hanna S.; Rylander, D.; Iderberg, H.; Andersson, Malin et al.

Ingår i Journal of Parkinson's Disease, s. 347-357, 2011.

DOI för Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period

Karlsson, Oskar; Roman, Erika; Berg, Anna-Lena; Brittebo, Eva

Ingår i Behavioural Brain Research, s. 310-320, 2011.

DOI för Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period
Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease

Ljungdahl, Anna; Hanrieder, Jörg; Fälth, Maria; Bergquist, Jonas et al.

Ingår i PLOS ONE, s. e25653-, 2011.

DOI för Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease Ladda ner fulltext (pdf) av Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease

Open access
L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry

Hanrieder, Jörg; Ljungdahl, Anna; Fälth, Maria; Eriksson Mammo, Sofie et al.

Ingår i Molecular & Cellular Proteomics, s. M111.009308-, 2011.

DOI för L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry Ladda ner fulltext (pdf) av L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry

Open access
MALDI mass spectrometry based molecular phenotyping of CNS glial cells for prediction in mammalian brain tissue

Hanrieder, Jörg; Wicher, Grzegorz; Bergquist, Jonas; Andersson, Malin et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 135-147, 2011.

DOI för MALDI mass spectrometry based molecular phenotyping of CNS glial cells for prediction in mammalian brain tissue

Senast uppdaterad: 2023-04-12