Senaste publikationer

Purification of DNA oligonucleotides to improve hybridization chain reaction performance

Leino, Mattias; Söderberg, Ola

Ingår i New Biotechnology, s. 33-40, 2023.

DOI för Purification of DNA oligonucleotides to improve hybridization chain reaction performance Ladda ner fulltext (pdf) av Purification of DNA oligonucleotides to improve hybridization chain reaction performance

The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Ingår i International Journal of Molecular Sciences, 2023.

DOI för The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ Ladda ner fulltext (pdf) av The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; Rubin Sander, Marie et al.

Ingår i Nature Communications, 2023.

DOI för Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs Ladda ner fulltext (pdf) av Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

Wåhlén, Erik; Olsson, Frida; Raykova, Doroteya; Söderberg, Ola et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 195-201, 2023.

DOI för Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion Ladda ner fulltext (pdf) av Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Ingår i BMC Molecular and Cell Biology, 2023.

DOI för SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation Ladda ner fulltext (pdf) av SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Olsson, Frida; Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan et al.

Ingår i Biochemistry and Biophysics Reports, 2022.

DOI för Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells Ladda ner fulltext (pdf) av Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2022.

DOI för Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling Ladda ner fulltext (pdf) av Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Wåhlén, Erik; Olsson, Frida; Söderberg, Ola; Lennartsson, Johan et al.

Ingår i Cellular Signalling, 2022.

DOI för Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling Ladda ner fulltext (pdf) av Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Ingår i Nature Communications, 2022.

DOI för A method for Boolean analysis of protein interactions at a molecular level Ladda ner fulltext (pdf) av A method for Boolean analysis of protein interactions at a molecular level

In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

Frances-Soriano, Laura; Leino, Mattias; Dos Santos, Marcelina Cardoso; Kovacs, Daniel et al.

Ingår i Analytical Chemistry, s. 1842-1850, 2021.

DOI för In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Rosén, Jacob; Norlin, Maria; Stattin, Karl; Lipcsey, Miklós et al.

Ingår i PLOS ONE, 2021.

DOI för ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study. Ladda ner fulltext (pdf) av ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.

Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Ingår i Bioorganic chemistry (Print), 2020.

DOI för Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Ingår i Theranostics, s. 1122-1135, 2020.

DOI för Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression Ladda ner fulltext (pdf) av Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2020.

DOI för Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

Zayny, Ahmad; Almokhtar, Mokhtar; Wikvall, Kjell; Ljunggren, Östen et al.

Ingår i Molecular and Cellular Endocrinology, 2019.

DOI för Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Wu, Chi-Chih; Klaesson, Axel; Buskas, Julia; Ranefall, Petter et al.

Ingår i Journal of Experimental Biology, 2019.

DOI för In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 469-474, 2019.

DOI för Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Leino, Mattias; Heldin, Johan; Rubin Sander, Marie; Kermpatsou, Despoina et al.

Ingår i Molecular Systems Design & Engineering, s. 1058-1065, 2019.

DOI för Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance Ladda ner fulltext (pdf) av Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Ingår i Experimental Cell Research, s. 69-79, 2019.

DOI för Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling Ladda ner fulltext (pdf) av Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Ingår i Journal of Cell Biology, s. 1701-1717, 2018.

DOI för PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Emanuelsson, Ida; Almokhtar, Mokhtar; Wikvall, Kjell; Gröndbladh, Alfhild et al.

Ingår i Neurochemistry International, s. 46-55, 2018.

DOI för Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Klaesson, Axel; Grannas, Karin; Ebai, Tonge; Heldin, Johan et al.

Ingår i Scientific Reports, 2018.

DOI för Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes Ladda ner fulltext (pdf) av Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Emanuelsson, Ida; Wikvall, Kjell; Friman, Tomas; Norlin, Maria

Ingår i Neuroscience, 2018.

DOI för Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Norlin, Maria; Lundqvist, Johan; Ellfolk, Maria; Hellström Pigg, Maritta et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 59-63, 2017.

DOI för Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Löf, Liza; Arngården, Linda; Olsson-Strömberg, Ulla; Siart, Benjamin et al.

Ingår i Scientific Reports, s. 1-9, 2017.

DOI för Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia Ladda ner fulltext (pdf) av Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Insufficient antibody validation challenges oestrogen receptor beta research

Andersson, Sandra; Sundberg, Mårten; Pristovsek, Nusa; Ibrahim, Ahmed et al.

Ingår i Nature Communications, 2017.

DOI för Insufficient antibody validation challenges oestrogen receptor beta research Ladda ner fulltext (pdf) av Insufficient antibody validation challenges oestrogen receptor beta research

Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Almokhtar, Mokhtar; Wikvall, Kjell; Ubhayasekera, S. J. Kumari A.; Bergquist, Jonas et al.

Ingår i Journal of Steroid Biochemistry and Molecular Biology, s. 178-188, 2016.

DOI för Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Wegler, Christine; Wikvall, Kjell; Norlin, Maria

Ingår i Basic & Clinical Pharmacology & Toxicology, 2016.

DOI för Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Wicher, Grzegorz; Norlin, Maria

Ingår i Journal of Steroid Biochemistry and Molecular Biology, s. 21-27, 2015.

DOI för Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Emanuelsson, Ida; Norlin, Maria

Ingår i Neuroscience Letters, s. 44-48, 2012.

DOI för Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Lundqvist, Johan; Wikvall, Kjell; Norlin, Maria

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 1553-1559, 2012.

DOI för Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

Lundqvist, Johan; Norlin, Maria

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 973-979, 2012.

DOI för Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 263-270, 2011.

DOI för 1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Norlin, Maria; Pettersson, Hanna; Tang, Wanjin; Wikvall, Kjell

Ingår i Archives of Biochemistry and Biophysics, s. 236-241, 2011.

DOI för Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

Svenningsen, Åsa Fex; Wicher, Grzegorz; Lundqvist, Johan; Pettersson, Hanna et al.

Ingår i Neurochemistry International, s. 620-624, 2011.

DOI för Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 1056-1062, 2010.

DOI för 1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

Pettersson, Hanna; Lundqvist, Johan; Norlin, Maria

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 1090-1097, 2010.

DOI för Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1)

Norlin, Maria; Wikvall, Kjell

Ingår i Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010.

Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Ellfolk, Maria; Norlin, Maria; Gyllensten, Katarina; Wikvall, Kjell

Ingår i Molecular Pharmacology, s. 1392-1399, 2009.

DOI för Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

Classen, Jean-Francois; Henrohn, Dan; Rorsman, Fredrik; Lennartsson, Johan et al.

Ingår i Arthritis and Rheumatism, s. 1137-1144, 2009.

DOI för Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

Pettersson, Hanna; Lundqvist, Johan; Oliw, Ernst; Norlin, Maria

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 1206-1215, 2009.

DOI för CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

CYP7B1 (cytochrome P450, family 7, subfamily B, polypeptide 1)

Norlin, Maria

Ingår i Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2009.

CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Pettersson, Hanna; Holmberg, Lisa; Axelson, Magnus; Norlin, Maria

Ingår i The FEBS Journal, s. 1778-1789, 2008.

DOI för CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Pettersson, Hanna; Norlin, Maria; Andersson, Ulla; Pikuleva, Irina et al.

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 383-390, 2008.

DOI för Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Tang, Wanjin; Pettersson, Hanna; Norlin, Maria

Ingår i Journal of Steroid Biochemistry and Molecular Biology, s. 63-73, 2008.

DOI för Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Ingår i Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, s. 718-723, 2008.

DOI för Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Ingår i Archives of Biochemistry and Biophysics, s. 13-20, 2007.

DOI för Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Hosseinpour, Fardin; Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 603-607, 2007.

DOI för Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Ingår i Drug Metab Dispos, s. 984-92, 2006.

Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells

Tang, Wanjin; Norlin, Maria

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 540-546, 2006.

DOI för Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells