Senaste publikationer

Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

Wåhlén, Erik; Olsson, Frida; Raykova, Doroteya; Söderberg, Ola et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 195-201, 2023.

DOI för Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion Ladda ner fulltext (pdf) av Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; Rubin Sander, Marie et al.

Ingår i Nature Communications, 2023.

DOI för Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs Ladda ner fulltext (pdf) av Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Purification of DNA oligonucleotides to improve hybridization chain reaction performance

Leino, Mattias; Söderberg, Ola

Ingår i New Biotechnology, s. 33-40, 2023.

DOI för Purification of DNA oligonucleotides to improve hybridization chain reaction performance Ladda ner fulltext (pdf) av Purification of DNA oligonucleotides to improve hybridization chain reaction performance

A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Ingår i Nature Communications, 2022.

DOI för A method for Boolean analysis of protein interactions at a molecular level Ladda ner fulltext (pdf) av A method for Boolean analysis of protein interactions at a molecular level

Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Wåhlén, Erik; Olsson, Frida; Söderberg, Ola; Lennartsson, Johan et al.

Ingår i Cellular Signalling, 2022.

DOI för Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling Ladda ner fulltext (pdf) av Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

Frances-Soriano, Laura; Leino, Mattias; Dos Santos, Marcelina Cardoso; Kovacs, Daniel et al.

Ingår i Analytical Chemistry, s. 1842-1850, 2021.

DOI för In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2020.

DOI för Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Ingår i Experimental Cell Research, s. 69-79, 2019.

DOI för Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling Ladda ner fulltext (pdf) av Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Wu, Chi-Chih; Klaesson, Axel; Buskas, Julia; Ranefall, Petter et al.

Ingår i Journal of Experimental Biology, 2019.

DOI för In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Leino, Mattias; Heldin, Johan; Rubin Sander, Marie; Kermpatsou, Despoina et al.

Ingår i Molecular Systems Design & Engineering, s. 1058-1065, 2019.

DOI för Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance Ladda ner fulltext (pdf) av Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Klaesson, Axel; Grannas, Karin; Ebai, Tonge; Heldin, Johan et al.

Ingår i Scientific Reports, 2018.

DOI för Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes Ladda ner fulltext (pdf) av Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Detection of Extracellular Vesicles Using Proximity Ligation Assay with Flow Cytometry Readout – ExoPLA: In Print

Löf, Liza; Arngården, Linda; Ebai, Tonge; Landegren, Ulf et al.

Ingår i Current Protocol in Cytometry, 2017.

DOI för Detection of Extracellular Vesicles Using Proximity Ligation Assay with Flow Cytometry Readout – ExoPLA: In Print

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Löf, Liza; Arngården, Linda; Olsson-Strömberg, Ulla; Siart, Benjamin et al.

Ingår i Scientific Reports, s. 1-9, 2017.

DOI för Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia Ladda ner fulltext (pdf) av Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Insufficient antibody validation challenges oestrogen receptor beta research

Andersson, Sandra; Sundberg, Mårten; Pristovsek, Nusa; Ibrahim, Ahmed et al.

Ingår i Nature Communications, 2017.

DOI för Insufficient antibody validation challenges oestrogen receptor beta research Ladda ner fulltext (pdf) av Insufficient antibody validation challenges oestrogen receptor beta research

Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses

Cane, Gaëlle; Leuchowius, Karl-Johan; Söderberg, Ola; Kamali-Moghaddam, Masood et al.

Ingår i Molecular Diagnostics (Third Edition), s. 219-231, 2017.

Antagonists of IGF: Vitronectin Interactions Inhibit IGF-I-Induced Breast Cancer Cell Functions

Kashyap, Abhishek S.; Shooter, Gary K.; Shokoohmand, Ali; McGovern, Jacqui et al.

Ingår i Molecular Cancer Therapeutics, s. 1602-1613, 2016.

DOI för Antagonists of IGF: Vitronectin Interactions Inhibit IGF-I-Induced Breast Cancer Cell Functions

Clinical Relevance Of Recurrent Allele-Specific Recombination Expressing The Wnt10Bivs1 Allele Variant In Acute Myeloid Leukemia

Beghini, A.; Lazzaroni, F.; Del Giacco, L.; Söderberg, Ola et al.

Ingår i Haematologica, s. 668-669, 2016.

Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout

Löf, Liza; Ebai, Tonge; Dubois, Louise; Wik, Lotta et al.

Ingår i Scientific Reports, 2016.

DOI för Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout Ladda ner fulltext (pdf) av Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout

Let There Be Light!

Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

Ingår i Proteomes, 2016.

DOI för Let There Be Light! Ladda ner fulltext (pdf) av Let There Be Light!

Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

Blokzijl, Andries; Zieba, Agata; Hust, Michael; Schirrmann, Thomas et al.

Ingår i Molecular & Cellular Proteomics, s. 1848-1856, 2016.

DOI för Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina et al.

Ingår i OncoTarget, s. 1120-1143, 2016.

DOI för The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling Ladda ner fulltext (pdf) av The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Visualization of Borna Disease Virus Protein Interactions with Host Proteins using in situ Proximity Ligation Assay

Johansson Wensman, Jonas; Leuchowius, Karl-Johan; Yan, Jiting; Berg, Anna-Lena et al.

Ingår i British journal of virology, s. 11-23, 2016.

DOI för Visualization of Borna Disease Virus Protein Interactions with Host Proteins using in situ Proximity Ligation Assay

Closing in on life - proximity dependent methods for life sciences

Koos, Björn; Söderberg, Ola

Ingår i OncoTarget, s. 17867-17868, 2015.

Compaction of rolling circle amplification products increases signal integrity and signal–to–noise ratio

Clausson, Carl-Magnus; Arngården, Linda; Ishaq, Omer; Klaesson, Axel et al.

Ingår i Scientific Reports, s. 12317:1-10, 2015.

DOI för Compaction of rolling circle amplification products increases signal integrity and signal–to–noise ratio

Crosstalk between Hippo and TGF beta: Subcellular Localization of YAP/TAZ/Smad Complexes

Grannas, Karin; Arngården, Linda; Lönn, Peter; Mazurkiewicz, Magdalena et al.

Ingår i Journal of Molecular Biology, s. 3407-3415, 2015.

DOI för Crosstalk between Hippo and TGF beta: Subcellular Localization of YAP/TAZ/Smad Complexes

Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours

Ricardo, Sara; Marcos-Silva, Lara; Pereira, Daniela; Pinto, Rita et al.

Ingår i Molecular Oncology, s. 503-512, 2015.

DOI för Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours

E-cadherin can limit the transforming properties of activating beta-catenin mutations

Huels, David J.; Ridgway, Rachel A.; Radulescu, Sorina; Leushacke, Marc et al.

Ingår i EMBO Journal, s. 2321-2333, 2015.

DOI för E-cadherin can limit the transforming properties of activating beta-catenin mutations

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Ingår i Journal of Experimental Medicine, s. 833-843, 2015.

DOI för Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia Ladda ner fulltext (pdf) av Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Next-Generation Pathology: Surveillance of Tumor Microecology

Koos, Björn; Kamali-Moghaddam, Masood; David, Leonor; Sobrinho-Simoes, Manuel et al.

Ingår i Journal of Molecular Biology, s. 2013-2022, 2015.

DOI för Next-Generation Pathology: Surveillance of Tumor Microecology

Proximity-dependent initiation of hybridization chain reaction

Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

Ingår i Nature Communications, 2015.

DOI för Proximity-dependent initiation of hybridization chain reaction Ladda ner fulltext (pdf) av Proximity-dependent initiation of hybridization chain reaction

Analysis of protein interactions in situ by proximity ligation assays

Koos, Björn; Andersson, Linda; Clausson, Carl-Magnus; Grannas, Karin et al.

Ingår i High-Dimensional Single Cell Analysis, s. 111-26, 2014.

DOI för Analysis of protein interactions in situ by proximity ligation assays

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Ingår i PLOS ONE, s. e103651-, 2014.

DOI för Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling Ladda ner fulltext (pdf) av Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-kappa B Deregulation in Aggressive Chronic Lymphocytic Leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Ingår i Blood, 2014.

Association of the Protein-Tyrosine Phosphatase DEP-1 with Its Substrate FLT3 Visualized by In Situ Proximity Ligation Assay

Bohmer, Sylvia-Annette; Weibrecht, Irene; Söderberg, Ola; Bohmer, Frank-D.

Ingår i PLOS ONE, s. e62871-, 2013.

DOI för Association of the Protein-Tyrosine Phosphatase DEP-1 with Its Substrate FLT3 Visualized by In Situ Proximity Ligation Assay Ladda ner fulltext (pdf) av Association of the Protein-Tyrosine Phosphatase DEP-1 with Its Substrate FLT3 Visualized by In Situ Proximity Ligation Assay

In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay

Weibrecht, Irene; Lundin, Elin; Kiflemariam, Sara; Mignardi, Marco et al.

Ingår i Nature Protocols, s. 355-372, 2013.

DOI för In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay

Parallel Visualization of Multiple Protein Complexes in Individual Cells in Tumor Tissue

Leuchowius, Karl-Johan; Clausson, Carl-Magnus; Grannas, Karin; Erbilgin, Yücel et al.

Ingår i Molecular & Cellular Proteomics, s. 1563-1571, 2013.

DOI för Parallel Visualization of Multiple Protein Complexes in Individual Cells in Tumor Tissue

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

Ribeiro, Ana Sofia; Sousa, Bárbara; Carreto, Laura; Mendes, Nuno et al.

Ingår i Journal of Pathology, s. 705-718, 2013.

DOI för P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

Gu, Gucci Jijuan; Friedman, Mikaela; Jost, Christian; Johnsson, Kai et al.

Ingår i New Biotechnology, s. 144-152, 2013.

DOI för Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

Sundqvist, Anders; Zieba, Agata; Vasilaki, Eleftheria; Herrera Hidalgo, Carmen et al.

Ingår i Oncogene, s. 3606-3615, 2013.

DOI för Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC

Figueiredo, Joana; Söderberg, Ola; Simoes-Correia, Joana; Grannas, Karin et al.

Ingår i European Journal of Human Genetics, s. 301-309, 2013.

DOI för The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC

Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Le Jan, Sébastien; Hayashi, Makoto; Kasza, Zsolt; Eriksson, Inger et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 1255-1263, 2012.

DOI för Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation

Pinto, Rita; Carvalho, Ana S.; Conze, Tim; Magalhães, Ana et al.

Ingår i Journal of Cellular and Molecular Medicine (Print), s. 1474-1484, 2012.

DOI för Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation

Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Zieba, Agata; Pardali, Katerina; Söderberg, Ola; Lindbom, Lena et al.

Ingår i Molecular & Cellular Proteomics, 2012.

DOI för Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Methods for analysis of the cancer microenvironment and their potential for disease prediction, monitoring and personalized treatments

Clausson, Carl-Magnus; Grundberg, Ida; Weibrecht, Irene; Nilsson, Mats et al.

Ingår i The EPMA journal, 2012.

DOI för Methods for analysis of the cancer microenvironment and their potential for disease prediction, monitoring and personalized treatments

Molecular tools for companion diagnostics

Zieba, Agata; Grannas, Karin; Söderberg, Ola; Gullberg, Mats et al.

Ingår i New Biotechnology, s. 634-640, 2012.

DOI för Molecular tools for companion diagnostics

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Dieterich, Lothar C.; Mellberg, Sofie; Langenkamp, Elise; Zhang, Lei et al.

Ingår i Journal of Pathology, s. 378-390, 2012.

DOI för Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Visualising individual sequence-specific protein-DNA interactions in situ

Weibrecht, Irene; Gavrilovic, Milan; Lindbom, Lena; Landegren, Ulf et al.

Ingår i New Biotechnology, s. 589-598, 2012.

DOI för Visualising individual sequence-specific protein-DNA interactions in situ

ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones

Figueiredo, Joana; Simoes-Correia, Joana; Söderberg, Ola; Suriano, Gianpaolo et al.

Ingår i PLOS ONE, s. e23188-, 2011.

DOI för ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones

Automated Classification of Multicolored Rolling Circle Products in Dual-Channel Wide-Field Fluorescence Microscopy

Gavrilovic, Milan; Weibrecht, Irene; Conze, Tim; Söderberg, Ola et al.

Ingår i Cytometry Part A, s. 518-527, 2011.

DOI för Automated Classification of Multicolored Rolling Circle Products in Dual-Channel Wide-Field Fluorescence Microscopy

In situ proximity ligation assay for microscopy and flow cytometry

Leuchowius, Karl Johan; Weibrecht, Irene; Söderberg, Ola

Ingår i Current Protocols in Cytometry, s. Unit 9.36-, 2011.

DOI för In situ proximity ligation assay for microscopy and flow cytometry