Senaste publikationer

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022.

DOI för 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands Ladda ner fulltext (pdf) av 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Zelleroth, Sofia; Nylander, Erik; Kjellgren, Ellinor; Gröndbladh, Alfhild et al.

Ingår i Behavioural Brain Research, 2022.

DOI för Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat Ladda ner fulltext (pdf) av Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Stam, Frida; Lind, Sara Florén; Schroff, Anja; Zelleroth, Sofia et al.

Ingår i Current Issues in Molecular Biology, s. 5000-5012, 2022.

DOI för Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures Ladda ner fulltext (pdf) av Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022.

DOI för Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds Ladda ner fulltext (pdf) av Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Ingår i European Journal of Pharmacology, 2021.

DOI för The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Gröndbladh, Alfhild et al.

Ingår i Brain Research Bulletin, s. 126-134, 2021.

DOI för The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Bakalkin, Georgy; Nosova, Olga; Sarkisyan, Daniil; Hallberg, Mathias et al.

Ingår i Experimental Brain Research, s. 2221-2232, 2021.

DOI för Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats Ladda ner fulltext (pdf) av Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats

Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Watanabe, Hiroyuki; Kononenko, Olga; Sarkisyan, Daniil; Andersen, Marlene Storm et al.

Ingår i eNeuro, 2021.

DOI för Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury Ladda ner fulltext (pdf) av Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury

Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

Bakalkin, Georgy; Kahle, Anika; Sarkisyan, Daniil; Watanabe, Hiroyuki et al.

Ingår i European Journal of Neuroscience, s. 5560-5573, 2021.

DOI för Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury Ladda ner fulltext (pdf) av Coordinated expression of the renin-angiotensin genes in the lumbar spinal cord: Lateralization and effects of unilateral brain injury

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Ingår i Bioorganic & Medicinal Chemistry, 2021.

DOI för N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Zelleroth, Sofia; Nylander, Erik; Örtenblad, Axel; Stam, Frida et al.

Ingår i Journal of Steroid Biochemistry and Molecular Biology, 2021.

DOI för Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures Ladda ner fulltext (pdf) av Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

Grönbladh, Alfhild; Nylander, Erik; Zelleroth, Sofia; Hallberg, Mathias

Ingår i Methods in Molecular Biology, s. 171-180, 2021.

DOI för Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat.

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Isaksson, Rebecka; Casselbrant, Anna; Elebring, Erik; Hallberg, Mathias et al.

Ingår i European Journal of Pharmacology, 2020.

DOI för Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages Ladda ner fulltext (pdf) av Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias et al.

Ingår i Metabolomics, 2020.

DOI för Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver Ladda ner fulltext (pdf) av Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Nylander, Erik; Zelleroth, Sofia; Stam, Frida; Nyberg, Fred et al.

Ingår i Growth Hormone & IGF Research, s. 42-47, 2020.

DOI för Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Ingår i ChemistryOpen, s. 325-337, 2020.

DOI för Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors Ladda ner fulltext (pdf) av Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Ingår i RSC Medicinal chemistry, s. 234-244, 2020.

DOI för Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Growing knowledge: How growth hormone improves learning

Nyberg, Fred; Hallberg, Mathias

Ingår i Acta Physiologica, 2020.

DOI för Growing knowledge: How growth hormone improves learning

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Vasile, Silvana; Hallberg, Anders; Sallander, Jessica; Hallberg, Mathias et al.

Ingår i Biomolecules, 2020.

DOI för Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists Ladda ner fulltext (pdf) av Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Mpakali, Anastasia; Saridakis, Emmanuel; Giastas, Petros; Maben, Zachary et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1429-1434, 2020.

DOI för Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Seyer, Benjamin; Diwakarla, Shanti; Burns, Peta; Hallberg, Anders et al.

Ingår i Journal of Neurochemistry, s. 485-494, 2020.

DOI för Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe, Hiroyuki; Nosova, Olga; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Ingår i Brain Communications, 2020.

DOI för Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism Ladda ner fulltext (pdf) av Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

Ingår i ChemistryOpen, s. 114-125, 2019.

DOI för A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode Ladda ner fulltext (pdf) av A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Ingår i MedChemComm, s. 2146-2160, 2019.

DOI för High affinity rigidified AT(2) receptor ligands with indane scaffolds Ladda ner fulltext (pdf) av High affinity rigidified AT(2) receptor ligands with indane scaffolds

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

Zelleroth, Sofia; Nylander, Erik; Nyberg, Fred; Grönbladh, Alfhild et al.

Ingår i Neuroscience, s. 172-183, 2019.

DOI för Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures Ladda ner fulltext (pdf) av Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Wannberg, Johan; Isaksson, Rebecka; Bremberg, Ulf; Backlund, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 519-522, 2018.

DOI för A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Reddy Vanga, Sudarsana; Sävmarker, Jonas; Ng, Leelee; Larhed, Mats et al.

Ingår i ACS Omega, s. 4509-4521, 2018.

DOI för Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides Ladda ner fulltext (pdf) av Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

Brolin, Erika; Zelleroth, Sofia; Jonsson, Anna; Hallberg, Mathias et al.

Ingår i Pharmacology, Biochemistry and Behavior, s. 1-8, 2018.

DOI för Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2446-2450, 2018.

DOI för An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Grönbladh, Alfhild et al.

Ingår i International Journal of Molecular Sciences, s. 1-16, 2018.

DOI för The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro Ladda ner fulltext (pdf) av The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 533-540, 2017.

DOI för Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 345-351, 2017.

DOI för Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Brolin, Erika; Johansson, Jenny; Zelleroth, Sofia; Diwakarla, Shanti et al.

Ingår i Neuroscience Letters, s. 15-20, 2017.

DOI för The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

Kalliomäki, Maija-Liisa; Sandblom, Gabriel; Hallberg, Mathias; Grönbladh, Alfhild et al.

Ingår i Scandinavian Journal of Pain, s. 1-6, 2016.

DOI för Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

Effects of growth hormone on brain function: new routes for the delivery of the hormone into the brain

Lai, Zhennan; Grönbladh, Alfhild; Hallberg, Mathias; Nyberg, Fred

Ingår i Amino Acids, s. 633-634, 2016.

Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Reddy Vanga, Sudarsana et al.

Ingår i Molecular Pharmacology, s. 413-424, 2016.

DOI för Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Nylander, Erik; Gröndbladh, Alfhild; Zelleroth, Sofia; Diwakarla, Shanti et al.

Ingår i Neuroscience, s. 538-547, 2016.

DOI för Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Engen, Karin; Rosenström, Ulrika; Axelsson, Hanna; Konda, Vivek et al.

Ingår i Assay and drug development technologies, s. 180-193, 2016.

DOI för Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Ingår i ACS Chemical Neuroscience, s. 1383-1392, 2016.

DOI för Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

[(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Grönbladh, Alfhild; Hallberg, Mathias

Ingår i Methods in Molecular Biology, s. 169-176, 2015.

DOI för [(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Ingår i ACS Medicinal Chemistry Letters, s. 178-182, 2015.

DOI för Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Jonsson, Anna; Fransson, Rebecca; Haramaki, Yutaka; Skogh, Anna et al.

Ingår i Neuroscience, s. 112-119, 2015.

DOI för Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Ingår i ChemistryOpen, s. 256-263, 2014.

DOI för Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Saralasin and Sarile Are AT2 Receptor Agonists

Guimond, Marie-Odile; Hallberg, Mathias; Gallo-Payet, Nicole; Wallinder, Charlotta

Ingår i ACS Medicinal Chemistry Letters, s. 1129-1132, 2014.

DOI för Saralasin and Sarile Are AT2 Receptor Agonists

Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

Johansson, Jenny; Grönbladh, Alfhild; Hallberg, Mathias

Ingår i Behavioural Brain Research, s. 164-174, 2014.

DOI för Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1272-1277, 2014.

DOI för Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Grönbladh, Alfhild; Johansson, Jenny; Nyberg, Fred; Hallberg, Mathias

Ingår i Growth Hormone & IGF Research, s. 60-66, 2014.

DOI för Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Growth hormone reverses streptozotocin-induced cognitive impairments in male mice

Enhamre-Brolin, Erika; Carlsson, Anna; Hallberg, Mathias; Nyberg, Fred

Ingår i Behavioural Brain Research, s. 273-278, 2013.

DOI för Growth hormone reverses streptozotocin-induced cognitive impairments in male mice

Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

Johansson, Jenny; Grönbladh, Alfhild; Nyberg, Fred; Hallberg, Mathias

Ingår i Brain Research Bulletin, s. 100-106, 2013.

DOI för Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013.

DOI för Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability