Pharmaceutical Bioinformatics

Pharmaceutical Bioinformatics is a new subject in the wake of the genomics revolution devoted to the field of drugs. Pharmaceutical Bioinformatics aims to make drug discovery and development more efficient, to improve the efficiency and safety of drugs and drug therapy, to understand the mechanism of actions drugs and how they interact with the organisms. Moreover, Pharmaceutical Bioinformatics is useful as a tool to understand the functions of the organisms, in particular from a chemical point of view.

Pharmaceutical Bioinformatics takes its stance from chemistry and the fact that all life processes are built from chemical structures, which interact and undergo change. By systematically using informatics approaches it is possible to describe all life processes in terms of chemical structure, interaction and change. This includes from simple processes of molecules up to complex biological processes, such as diseases and the effect of drug therapy.

Pharmaceutical Bioinformatics requires methods for storage and retrieval of the large amounts of chemical and biological data generated in drug discovery (i.e. drug screening data, DNA sequencing, transcriptome analysis, proteomics, metabolomics and others). This requires development of data standards, tools for mathematical statistical analysis and software as well as high-performance e-infrastructures such as computer clusters, cloud computing environments, and frameworks for Big Data analytics.

A recent summary of the field of Pharmaceutical Bioinformatics is available in the textbook "Introduction to Pharmaceutical Bioinformatics" by Jarl E.S. Wikberg et al., published by Oakleaf Academic in 2010.

The research is focused on the following areas:

Proteochemometrics and drug development (Prof. Jarl Wikberg)

Data-intensive and translational bioinformatics (Assist. Prof. Ola Spjuth)